Cited by 121Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.

Adaptation and Maladaptation of the Heart in Obesity

Open access

Harmancey, Romain, Wilson, Christopher R., Taegtmeyer, Heinrich·2008·Hypertension

DOI 10.1161/hypertensionaha.108.110031PMC PMC3660087

Open this paper in CoChat — free account Open PDF

Abstract

O besity appears to be a major cause of hypertension and associated cardiovascular pathophysiology, including cardiac dysfunction.However, obesity may lead to abnormal cardiac function through mechanisms that are independent of, or that act in concert with, hypertension.One hypothesis of obesity-induced cardiac dysfunction is that an oversupply of substrates leads first to adaptive changes and eventually to contractile dysfunction of the heart.We reason that increased supply of nonesterified fatty acids, together with metabolic dysregulation in obesity, including an inadequate activation of fat oxidation, results in the accumulation of toxic lipid byproducts and subsequent contractile dysfunction.Although the phenomenon may have already been known to Virchow 1 when he described "fatty metamorphosis" of the heart, the concept of cardiac "lipotoxicity" re-emerged only recently with its description in the heart of the obese Zucker diabetic fatty rat. 2 The concept is, however, still a hypothesis rather than an established physiological principle.In spite of the many investigations performed in rodent models, the mechanism(s) responsible for impaired contractile function of the heart is still obscure, and it is uncertain whether lipid metabolites contribute to "obesity cardiomyopathy" in humans.Our brief review is an attempt to understand the chronic regulatory effects of changes in systemic metabolism on cardiac function.In other words, we discuss current concepts of cardiac adaptation and maladaptation to a deranged metabolic environment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.108.110031

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Retracted
Untitled work
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390
Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects
Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285
Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265

Show all 100 references

Research works printed but not linked: 3

10.1161/circ.64.3.7261280 · DOI
10.1001/jama.1991.03470020057032 · DOI
10.1161/res.88.9.918 · DOI

Sorted by citations

Obesity and inflammation: the linking mechanism and the complications
Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2017) · Archives of Medical Science · doi:10.5114/aoms.2016.58928 · Cited by 1,982
The randle cycle revisited: a new head for an old hat.
Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743
Self-citation
Effects of Exercise to Improve Cardiovascular Health
Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 517
A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13
Grueter, C. E., van Rooij, E., Johnson, B. A., DeLeon, S. M., Sutherland, L. B., Qi, X., Gautron, L., Elmquist, J. K., Bassel‐Duby, R., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.03.029 · Cited by 368
Lipotoxicity in the heart
Wende, A. R., & Abel, E. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.023 · Cited by 352
Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: Basic mechanisms and clinical associations
Fitzgibbons, T. P., & Czech, M. P. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000582 · Cited by 331
AMPK, Mitochondrial Function, and Cardiovascular Disease
Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286
Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications
Alpert, M. A., Karthikeyan, K., Abdullah, O., & Ghadban, R. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.012 · Cited by 221
Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions
Hirabara, S. M., Gorjão, R., Vinolo, M. A. R., Rodrigues, A. C., Nachbar, R. T., & Curi, R. (2012) · BioMed Research International · doi:10.1155/2012/379024 · Cited by 180
Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective
Gusdon, A. M., Song, K., & Qu, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/637027 · Cited by 172
The Adrenergic-Fatty Acid Load in Heart Failure
Opie, L. H., & Knuuti, J. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.024 · Cited by 158
Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition
Vercesi, A. E., Castilho, R. F., Kowaltowski, A. J., Oliveira, H. C. F., de Souza-Pinto, N. C., Figueira, T. R., & Busanello, E. N. B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.034 · Cited by 146
Association of Obesity and Hypertension With Left Ventricular Geometry and Function in Children and Adolescents
Dhuper, S., Abdullah, R. A., Weichbrod, L., Mahdi, E. S., & Cohen, H. W. (2010) · Obesity · doi:10.1038/oby.2010.134 · Cited by 127
Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in DrosophilaPreprint
Lim, H., Wang, W., Wessells, R. J., Ocorr, K. A., & Bodmer, R. (2011) · Genes & Development · doi:10.1101/gad.1992411 · Cited by 120
Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: Relationship to metabolic profile, cardiac function and visceral fat
Gaborit, B., Kober, F., Jacquier, A., Moro, P. J., Cuisset, T., Boullu, S., Dadoun, F., Alessi, M.-C., Morange, P., Clément, K., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.117 · Cited by 116
Role of ceramides in the pathogenesis of diabetes mellitus and its complications
Mandal, N. A., Grambergs, R. C., Mondal, K., Basu, S. K., Tahia, F., & Dagogo-Jack, S. E. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107734 · Cited by 112
The Role of p38 MAPK in the Development of Diabetic Cardiomyopathy
Wang, S., Ding, L., Ji, H., Xu, Z., Liu, Q., & Zheng, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071037 · Cited by 102
Insulin resistance protects the heart from fuel overload in dysregulated metabolic states
Taegtmeyer, H., Beauloye, C., Harmancey, R., & Hue, L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00854.2012 · Cited by 97
Self-citation
MED13‐dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver
Baskin, K. K., Grueter, C. E., Kusminski, C. M., Holland, W. L., Bookout, A. L., Satapati, S., Kong, Y. M., Burgess, S. C., Malloy, C. R., Scherer, P. E., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404218 · Cited by 92
Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation
Cao, K., Xu, J., Pu, W., Dong, Z., Sun, L., Zang, W., Gao, F., Zhang, Y., Feng, Z., & Liu, J. (2015) · Scientific Reports · doi:10.1038/srep14014 · Cited by 90
Sudden cardiac death and obesity
Plourde, B., SARRAZIN, J., Nault, I., & Poirier, P. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.952283 · Cited by 93
Sphingolipids, Lipotoxic Cardiomyopathy, and Cardiac Failure
Park, T., & Goldberg, I. J. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.003 · Cited by 82
Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway
Lam, T., Harmancey, R., Vasquez, H., Gilbert, B., Patel, N., Hariharan, V., Lee, A., Covey, M., & Taegtmeyer, H. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.61 · Cited by 83
Self-citation
Progressive Regression of Left Ventricular Hypertrophy Two Years after Bariatric Surgery
Algahim, M. F., Lux, T. R., Leichman, J. G., Boyer, A. F., Miller, C. C., Laing, S. T., Wilson, E. B., Scarborough, T. K., Yu, S. C., Snyder, B., et al. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.11.020 · Cited by 76
Self-citation
Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity
Pulinilkunnil, T., Kienesberger, P. C., Nagendran, J., Sharma, N., Young, M. E., & Dyck, J. R. B. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.103 · Cited by 71
Protective Mechanisms of Mitochondria and Heart Function in Diabetes
Aon, M. A., Tocchetti, C. G., Bhatt, N., Paolocci, N., & Cortassa, S. C. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6123 · Cited by 71
Mice With Cardiac Overexpression of Peroxisome Proliferator–Activated Receptor γ Have Impaired Repolarization and Spontaneous Fatal Ventricular Arrhythmias
Morrow, J., Katchman, A. N., Son, N.-H., Trent, C. M., Khan, R. S., Shiomi, T., Huang, H., Amin, V., Lader, J. M., Vásquez, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.056309 · Cited by 70
Adiponectin receptor agonist ameliorates cardiac lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice
Kim, Y., Lim, J. H., Kim, E. N., Hong, Y. A., Park, H., Chung, S., Choi, B. S., Kim, Y., Park, J. Y., Kim, H. W., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04726-8 · Cited by 68
Tracing Cardiac Metabolism In Vivo: One Substrate at a Time
Taegtmeyer, H. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.068205 · Cited by 63
Self-citation
Effects of Sleep Apnea on Nocturnal Free Fatty Acids in Subjects with Heart Failure
Jun, J. C., Drager, L. F., Najjar, S. S., Gottlieb, S. S., Brown, C. D., Smith, P. L., Schwartz, A. R., & Polotsky, V. Y. (2011) · SLEEP · doi:10.5665/sleep.1240 · Cited by 65
Taking pressure off the heart: the ins and outs of atrophic remodelling
Baskin, K. K., & Taegtmeyer, H. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr060 · Cited by 62
Self-citation
Hearts from Mice Fed a Non-Obesogenic High-Fat Diet Exhibit Changes in Their Oxidative State, Calcium and Mitochondria in Parallel with Increased Susceptibility to Reperfusion Injury
Littlejohns, B., Pasdois, P., Duggan, S. M. J., Bond, A., Heesom, K. J., Jackson, C. L., Angelini, G. D., Halestrap, A. P., & Suleiman, M. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100579 · Cited by 58
Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy
Chen, Z., Jin, Z., Cai, J., Li, R., Deng, K., Ji, Y., Lei, F., Li, H., Lu, Z., & Li, H. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02269-1 · Cited by 58
Lipoprotein lipase activity is required for cardiac lipid droplet production
Trent, C. M., Yu, S., Hu, Y., Skoller, N., Huggins, L. A., Homma, S., & Goldberg, I. J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m043471 · Cited by 55
Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide
Baranowski, M., Błachnio-Zabielska, A. U., Hirnle, T., Harasiuk, D., Matlak, K., Knapp, M., Zabielski, P., & Górski, J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900002-jlr200 · Cited by 50
Beneficial Effects of Bariatric Surgery on Cardiac Structure and Function in Obesity
Shin, S., Lee, Y. J., Heo, Y., Park, S., Kwon, S., Woo, S., Kim, D., Park, K. S., & Kwan, J. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2330-x · Cited by 50
The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure
Werbner, B., Tavakoli‐Rouzbehani, O. M., Fatahian, A. N., & Boudina, S. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.42 · Cited by 44
Low density lipoprotein receptor–related protein 1 is upregulated in epicardial fat from type 2 diabetes mellitus patients and correlates with glucose and triglyceride plasma levels
Nasarre, L., Juan‐Babot, O., Gastelurrutia, P., Valldeperas, A. L., Badimón, L., Bayés‐Genís, A., & Llorente‐Cortés, V. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0436-8 · Cited by 44
Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis
Harmancey, R., Wilson, C. R., Wright, N. R., & Taegtmeyer, H. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m001230 · Cited by 44
Self-citation
Heart Sphingolipids in Health and Disease
Baranowski, M., & Górski, J. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0650-1_3 · Cited by 41
The Impact of Extra Cardiac Comorbidities on Pressure Volume Relations in Heart Failure and Preserved Ejection Fraction
Abramov, D., He, K., Wang, J., Burkhoff, D., & Maurer, M. S. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.03.010 · Cited by 40
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
Shero, J. A., Lindholm, M. E., Sandri, M. F., & Stanford, K. I. (2025) · Circulation Research · doi:10.1161/circresaha.124.325614 · Cited by 45
Proteomics applied to exercise physiology: A cutting‐edge technology
Petriz, B. A., Gomes, C. P. C., Rocha, L. A. O., Rezende, T. M. B., & Franco, O. L. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22809 · Cited by 39
Too much or not enough of a good thing? Cardiac glucolipotoxicity versus lipoprotection
Taegtmeyer, H., & Stanley, W. C. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.09.014 · Cited by 38
Self-citation
Myocardial metabolic alterations in mice with diet-induced atherosclerosis: linking sulfur amino acid and lipid metabolism
Lee, J., Jung, S., Kim, N., Shin, M., Ryu, D. H., & Hwang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-13991-z · Cited by 37
MRS: a noninvasive window into cardiac metabolism
van Ewijk, P. A., Schrauwen‐Hinderling, V. B., Bekkers, S. C. A. M., Glatz, J. F. C., Wildberger, J. E., & Kooi, M. E. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3320 · Cited by 36
Rethinking cardiac metabolism: metabolic cycles to refuel and rebuild the failing heart
Taegtmeyer, H., & Lubrano, G. (2014) · F1000Prime Reports · doi:10.12703/p6-90 · Cited by 32
Self-citation
Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice
Zhang, Y., Bao, M., Dai, M., Wang, X., He, W., Tan, T., Lin, D., Wang, W., Wen, Y. R., & Zhang, R. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0234-z · Cited by 33
Relevance and consequence of chronic inflammation for obesity development
Rück, L., Wiegand, S., & Kühnen, P. (2023) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-023-00170-6 · Cited by 35
Myocardial Fatty Acid Metabolism and Lipotoxicity in the Setting of Insulin Resistance
Kok, B. P., & Brindley, D. N. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.008 · Cited by 29
Extreme Obesity and Associated Cardiovascular Disease Verified at Autopsy
Kortelainen, M., & Porvari, K. (2011) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e318219cd89 · Cited by 29
Coenzyme A–mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice
Schafer, C. M., Young, Z. T., Makarewich, C. A., Elnwasany, A., Kinter, C. S., Kinter, M. T., & Szweda, L. I. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000268 · Cited by 25
The Crosstalk Between Immune Activation and Metabolism in Heart Failure. A Scientific Statement of the Heart Failure Association of the ESC
Fragasso, G., Stolfo, D., Anker, M. S., Bayés‐Genís, A., Chioncel, O. D., Heymans, S. R. B., Jhund, P. S., Lewis, B. S., Lopaschuk, G. D., Lund, L. H., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3703 · Cited by 31
The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome
Llano‐Diez, M., Sinclair, J., Yamada, T., Zong, M., Fauconnier, J., Zhang, S., Katz, A., Jardemark, K. E., Westerblad, H., Andersson, D. C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167090 · Cited by 24
Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention
Yao, Y., Jia, X., & Li, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044923 · Cited by 25
The effect of obesity and subsequent weight reduction on cardiac structure and function in dogs
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V. C., & German, A. J. (2022) · BMC Veterinary Research · doi:10.1186/s12917-022-03449-4 · Cited by 26
The number of cardiac myocytes in the hypertrophic and hypotrophic left ventricle of the obese and calorie‐restricted mouse heart
Schipke, J., Banmann, E., Nikam, S., Voswinckel, R., Kohlstedt, K., Loot, A. E., Fleming, I., & Mühlfeld, C. (2014) · Journal of Anatomy · doi:10.1111/joa.12236 · Cited by 20
Energy metabolism homeostasis in cardiovascular diseases.
Wang, L.-Y., & Chen, C. (2021) · PubMed Central · doi:10.11909/j.issn.1671-5411.2021.12.006 · Cited by 18
The effects of rosiglitazone on myocardial triglyceride content in patients with type 2 diabetes: A randomised, placebo-controlled trial
McGavock, J., Szczepaniak, L. S., Ayers, C. R., Abdullah, S. M., See, R., Gore, M. O., Drazner, M. H., de Lemos, J. A., & McGuire, D. K. (2011) · Diabetes and Vascular Disease Research · doi:10.1177/1479164111428628 · Cited by 18
Intracerebroventricular Leptin Administration Differentially Alters Cardiac Energy Metabolism in Mice Fed a Low-fat and High-fat Diet
Keung, W., Cadete, V. J. J., Palaniyappan, A., Jablonski, A., Fischer, M. A., & Lopaschuk, G. D. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31820014f9 · Cited by 17
Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling
Liang, Y., Lang, A. L., Zhang, J., Chen, J., Wang, K., Chen, L., Beier, J. I., Qian, Y., & Cai, L. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00043 · Cited by 16
Significance of mitochondria on cardiometabolic syndromes
Nair, A., Sindhu, G., & Raghu, K. G. (2018) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12359 · Cited by 16
The Role of Mitochondria in Metabolic Syndrome–Associated Cardiomyopathy
Li, J., Li, J., Chen, Y., Hu, W., Gong, X., Qiu, H., Chen, H., Xin, Y., & Li, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9196232 · Cited by 17
Effect of dietary vegetable oil consumption on blood glucose levels, lipid profile and weight in diabetic mice: an experimental case—control study
Ngala, R. A., Ampong, I., Sakyi, S. A., & Anto, E. O. (2016) · BMC Nutrition · doi:10.1186/s40795-016-0053-y · Cited by 16
The Patterns of Left Ventricular Alteration by Adipose Tissue Distribution: Implication for Heart Failure Prevention
Cai, A., Liu, L., Zhou, D., Zhou, Y., Tang, S., & Feng, Y. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13415 · Cited by 13
In obese mice, exercise training increases 11β-HSD1 expression, contributing to glucocorticoid activation and suppression of pulmonary inflammation
Du, S., Yu, Q., Chuan, K., Ye, C., He, Z., Liu, S., Zhu, X., & Liu, Y. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00652.2016 · Cited by 12
Is increased myocardial triglyceride content associated with early changes in left ventricular function? A 1H-MRS and MRI strain study
Soghomonian, A., Dutour, A., Kachenoura, N., Thuny, F., Lasbleiz, A., Ancel, P., Cristofari, R., Jouve, É., Siméoni, U., Kober, F., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1181452 · Cited by 10
Obesity related changes in cardiac structure and function: role of blood pressure and metabolic abnormalities
Chiara, T. D., Tuttolomondo, A., Parrinello, G., Colomba, D., Pinto, A. V., & Scaglione, R. (2019) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2019.1598638 · Cited by 10
Laparoscopic Roux-en-Y gastric bypass in patients with body mass index >70 kg/m2
Roland, J. C., Needleman, B. J., Muscarella, P., Cook, C. H., Narula, V. K., & Mikami, D. J. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2011.02.010 · Cited by 9
Management of left ventricular diastolic heart failure: is it only blood pressure control?
Koprowski, A., Gruchała, M., & Rynkiewicz, A. (2009) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328320d530 · Cited by 9
Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse
Mühlfeld, C., Pfeiffer, C., Schneider, V., Bornemann, M., & Schipke, J. (2020) · Histochemistry and Cell Biology · doi:10.1007/s00418-020-01926-1 · Cited by 8
Strategies for Imaging Metabolic Remodeling of the Heart in Obesity and Heart Failure
Haidar, A., & Taegtmeyer, H. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01650-3 · Cited by 8
Self-citation
Myocardial macronutrient transporter adaptations in the adult pregestational female intrauterine and postnatal growth-restricted offspring
Abbasi, A., Thamotharan, M., Shin, B., Jordan, M. C., Roos, K. P., Stahl, A., & Devaskar, S. U. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00539.2011 · Cited by 9
Nup93-Mediated RNA Alternative Splicing Associated With Diabetic Atherosclerosis
Yuan, X., Zhang, Q., Li, J., Zhang, Z., Ye, S., & Zhou, W. (2025) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2025.101029 · Cited by 7
Regular Exercise in Drosophila Prevents Age-Related Cardiac Dysfunction Caused by High Fat and Heart-Specific Knockdown of skd
Cao, Y., He, S., Ding, M., Gu, W., Wang, T., Zhang, S., Feng, J., Li, Q., & Zheng, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021216 · Cited by 7
Prognostic impact of diabetes in chronic and acute heart failure
Ghio, S., Mercurio, V., Attanasio, A. F., Asile, G., Tocchetti, C. G., & Paolillo, S. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10193-8 · Cited by 6
Heart Failure, Obesity and Bariatric Surgery
Reigle, J. (2009) · Progress in Cardiovascular Nursing · doi:10.1111/j.1751-7117.2009.00023.x · Cited by 6
Physiopathologie, déterminants et complications de l’obésité
Faucher, P., & Poitou, C. (2016) · Soins · doi:10.1016/j.soin.2016.10.003 · Cited by 8
Complications des obésités
Ciangura, C., & Poitou, C. (2011) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(11)51424-6 · Cited by 6
Pathophysiology of obesity. Impact on laparoscopy.
Mulier, J. P., Garcia, M., & Dillemans, B. (2009) · PubMed · Cited by 5
The effect of obesity and subsequent weight reduction on cardiac morphology and function in cats
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V. C., & German, A. J. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-04011-0 · Cited by 4
Stereological Estimation of Myocardial Fat and Its Associations with Obesity, Epicardial, and Visceral Adipose Tissue
Holm, P. H., Hindsø, L., Olsen, K. B., & Banner, J. (2022) · Cells · doi:10.3390/cells11193160 · Cited by 4
Fat Around the Heart
Thomas, S., Harmancey, R., & Taegtmeyer, H. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2010.05.001 · Cited by 4
Self-citation
Nutritional Regulation of Cardiac Metabolism and Function: Molecular and Epigenetic Mechanisms and Their Role in Cardiovascular Disease Prevention
Capasso, L., Mele, D., Casalino, R., Favale, G., Rollo, G., Verrilli, G., Conte, M., Bontempo, P., Carafa, V., Altucci, L., et al. (2025) · Nutrients · doi:10.3390/nu18010093 · Cited by 5
The location of adipose tissue is important: epicardial fat in patients with chronic kidney disease
Zoccali, C., & Mallamaci, F. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12356 · Cited by 3
Impaired coronary collateral growth: miR-shaken neutrophils caught in the act
Bagi, Z. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00274.2015 · Cited by 3
Regulation of mitochondrial biogenesis and energy metabolism in the heart
She, P., 莫非, Zhu, P., & Zhong, T. P. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004011 · Cited by 2
Five-year longitudinal changes in oxygen saturation parameters in Obstructive Sleep Apnoea: Impact of age, body mass index, and comorbidities
Howarth, T. P., Karhu, T., Leppänen, T., Saad, H. B., Bahammam, A., & Nikkonen, S. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108866 · Cited by 2
Cardiac Remodeling: The Course Toward Heart Failure – I. General Concepts
Cokkinos, D. V. (2019) · Springer eBooks · doi:10.1007/978-3-319-98186-4_12 · Cited by 2
Phenotyping transgenic animals—An integrated readout of pathophysiology by combining proteomics and metabolomics with cardiovascular imaging
Püntmann, V. O., & Mayr, M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.12.001 · Cited by 2
APpEaLINg therapeutic target for obesity cardiomyopathy?
Wende, A. R., & Young, M. E. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.08.001 · Cited by 1
All things considered-including glucose control in the ICU
Lux, T. R., & Taegtmeyer, H. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0066-x · Cited by 1
Self-citation
Alterations in Cardiac Metabolism
Peterson, L. R., Schilling, J. D., & Taegtmeyer, H. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5895-3.10020-8 · Cited by 1
Self-citation
Cardiac hypertrophy and heart failure: From the case to review of literature
Massoni, F., Ricci, L., Simeone, C., Onofri, E., & Ricci, S. (2016) · Eastern Journal Of Medicine · doi:10.5505/ejm.2016.27247 · Cited by 1
Структура і функція серця залежно від маси тіла у чоловіків працездатного віку
Dudar, L. V., Goncharenco, L. I., & Овдій, М. О. (2014) · Likarska sprava · doi:10.31640/ls-2014-(1-2)-14 · Cited by 1
APOO, une protéine mitochondriale impliquée dans la cardiomyopathie diabétique
Rouet, P., Harmancey, R., Turkieh, A., Caubère, C., Barutaut, M., Koukoui, F., Dambrin, C., Galinier, M., & Smih, F. (2015) · médecine/sciences · doi:10.1051/medsci/20153101010 · Cited by 1
Self-citation
Myocardial Metabolic Abnormalities and Cardiac Dysfunction
Kienesberger, P. C. (2015) · Springer eBooks · doi:10.1007/978-3-319-15961-4_17
Avaliação das concentrações séricas de adiponectina e sua correlação com obesidade e endocardiose de valva mitral em cães
Machado, F. L. A. (2012) · doi:10.11606/d.10.2012.tde-26032013-102524
Fat in hearts: Uptake, storage, and turnover
Trent, C. M. (2014) · doi:10.7916/d8c53j0x
The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states
Nduhirabandi, F. (2014) · SUNScholar (Stellenbosch University)

Authors: Harmancey, R., Wilson, C. R., & Taegtmeyer, H.
Affiliations: Texas Medical Center (US)
ORCID: Harmancey, Romain
Taegtmeyer, Heinrich
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-08
Volume: 52
Issue: 2
Pages: 181-187
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.108.110031
PMC: PMC3660087
OpenAlex: W2137438717
Cited by: 121
References: 100
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 4 · 2012: 10
FWCI: 1.66
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL061483, R01HL073162)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: obesity, obesity cardiomyopathy, cardiac dysfunction, lipotoxicity, free fatty acids, fat oxidation, lipid accumulation, contractile dysfunction, cardiac adaptation, metabolic dysfunction, Zucker diabetic fatty rats
MeSH terms: Adaptation, Physiological, Animals, Disease Models, Animal, Fatty Acids, Nonesterified, Female, Heart Failure, Humans, Male, Myocardial Contraction, Myocardium, Obesity, Morbid, Prognosis, Severity of Illness Index, Cohort Studies, Body Mass Index, Reactive Oxygen Species, Risk Assessment, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adaptation and Maladaptation of the Heart in Obesity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks