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Arterial Pulse Wave Velocity and Cognition With Advancing Age
Open accessAbstract
We hypothesized that carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, interacts with age such that the magnitude of associations between PWV and cognitive performance are greater with increasing age and that this interaction is observed despite adjustments for demographic variables, mean arterial pressure, and cardiovascular risk factors. PWV was estimated using applanation tonometry in 409 dementia- and stroke-free participants of the Maine-Syracuse Longitudinal Study (24 to 92 years of age; 62.3% women). Using linear regression analyses in a cross-sectional design, associations between PWV and age and the interaction of PWV and age were examined in relation to a global composite score, the Wechsler Adult Intelligence Scale Similarities test (abstract reasoning), and 4 cognitive domains indexed by multiple cognitive measures. Adjusting for age, gender, education, height, weight, heart rate, mean arterial pressure, and antihypertensive treatment, PWV-by-age interactions were obtained for the global, visual-spatial organization and memory, scanning and tracking, and verbal episodic memory composites, as well as similarities. The combination of higher PWV and age resulted in progressively lower cognitive performance. This finding was the same with an extended model, which also included adjustment for cardiovascular risk factors and other confounds. PWV interacts with age in a multiplicative way to exert a negative influence on cognitive performance level. Early interventions to prevent an increase in arterial stiffness could possibly play an important role in the preservation of cognitive ability.
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“An inverse relationship between pulse wave velocity and cognitive performance was reported cross-sectionally.186,202,203”
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Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness
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ResultA major role for cardiovascular burden in age-related cognitive decline
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Metadata
- Authors
- Elias, M. F., Robbins, M. A., Budge, M. M., Abhayaratna, W. P., Dore, G. A., & Elias, P. K.
- Affiliations
- Australian National University (AU)
- Venue
- Hypertension
- Published
- 2009-04
- Volume
- 53
- Issue
- 4
- Pages
- 668-673
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC2716128
- OpenAlex
- W2041077485
- Cited by
- 176
- References
- 40
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 13 · 2018: 7 · 2017: 17 · 2016: 15 · 2015: 15 · 2014: 18 · 2013: 11 · 2012: 4
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- DigitalCommons (California Polytechnic State University) (submittedVersion)
- Funders
- National Institute on Aging (AG-03055, R37AG003055)
- National Heart, Lung, and Blood Institute (R01HL067358, 1R01-HL67358, R01HL081290, R01HL065177)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- pulse wave velocity, arterial stiffness, cognitive performance, aging, carotid-femoral pulse wave velocity, applanation tonometry, age interaction, abstract thinking, memory, verbal episodic memory, cognitive decline, cardiovascular risk factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Blood Flow Velocity, Blood Pressure, Carotid Arteries, Cognition, Cognition Disorders, Cross-Sectional Studies, Female, Femoral Artery, Humans, Hypertension, Male, Middle Aged, Pulsatile Flow, Regression Analysis, Risk Factors, Wechsler Scales, Young Adult
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