The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans
Open accessAbstract
Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible. The effects of pollution on heart rate variability, blood pressure, biomarkers, and brachial flow-mediated dilatation were determined in 2 randomized, double-blind, crossover studies. In Ann Arbor, 50 subjects were exposed to fine particles (150 μg/m 3 ) plus ozone (120 parts per billion) for 2 hours on 3 occasions with pretreatments of an endothelin antagonist (Bosentan, 250 mg), antioxidant (Vitamin C, 2 g), or placebo. In Toronto, 31 subjects were exposed to 4 different conditions (particles plus ozone, particles, ozone, and filtered air). In Toronto, diastolic blood pressure significantly increased (2.9 and 3.6 mm Hg) only during particle-containing exposures in association with particulate matter concentration and reductions in heart rate variability. Flow-mediated dilatation significantly decreased (2.0% and 2.9%) only 24 hours after particle-containing exposures in association with particulate matter concentration and increases in blood tumor necrosis factor α. In Ann Arbor, diastolic blood pressure significantly similarly increased during all of the exposures (2.5 to 4.0 mm Hg), a response not mitigated by pretreatments. Flow-mediated dilatation remained unaltered. Particulate matter, not ozone, was responsible for increasing diastolic blood pressure during air pollution inhalation, most plausibly by instigating acute autonomic imbalance. Only particles from urban Toronto additionally impaired endothelial function, likely via slower proinflammatory pathways. Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences.
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Cites
Health Effects of Fine Particulate Air Pollution: Lines that Connect
Pope, C. A., & Dockery, D. W. (2006) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.2006.10464485 · Cited by 6,583
Brook, R. D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Luepker, R., Mittleman, M., Samet, J., Smith, S. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128587.30041.c8 · Cited by 2,380
Self-citationIncreased Particulate Air Pollution and the Triggering of Myocardial Infarction
Peters, A., Dockery, D. W., Muller, J. E., & Mittleman, M. A. (2001) · Circulation · doi:10.1161/01.cir.103.23.2810 · Cited by 1,471
Self-citationExposure to Traffic and the Onset of Myocardial Infarction
Peters, A., von Klot, S., Heier, M., Trentinaglia, I., Hörmann, A., Wichmann, H. E., & Löwel, H. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040203 · Cited by 915
Sun, Q. (2005) · JAMA · doi:10.1001/jama.294.23.3003 · Cited by 853
Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., & Silverman, F. (2002) · Circulation · doi:10.1161/01.cir.0000013838.94747.64 · Cited by 845
Self-citationCardiovascular effects of air pollution
Brook, R. D. (2008) · Clinical Science · doi:10.1042/cs20070444 · Cited by 657
Self-citationDiesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis
Mills, N. L., Törnqvist, H., Robinson, S. D., Gonzalez, M., Darnley, K., MacNee, W., Boon, N. A., Donaldson, K., Blomberg, A., Sandstrom, T., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.588962 · Cited by 646
Mills, N. L., Törnqvist, H., Gonzalez, M. C., Vink, E., Robinson, S. D., Söderberg, S., Boon, N. A., Donaldson, K., Sandström, T., Blomberg, A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066314 · Cited by 642
National Ambient Air Quality Standards
Brunner, C. R. (1985) · Hazardous Air Emissions from Incineration · doi:10.1007/978-1-4613-2539-0_3 · Cited by 594
Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Self-citationAir Pollution and Cardiovascular Disease
Rajagopalan, S., Al-Kindi, S. G., & Brook, R. D. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.07.099 · Cited by 1,299
Self-citationExpert position paper on air pollution and cardiovascular disease
Newby, D. E., Mannucci, P. M., Tell, G. S., Baccarelli, A. A., Brook, R. D., Donaldson, K., Forastiere, F., Franchini, M., Franco, O. H., Graham, I., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu458 · Cited by 869
Self-citationEnvironmental determinants of cardiovascular disease: lessons learned from air pollution
Al-Kindi, S. G., Brook, R. D., Biswal, S., & Rajagopalan, S. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0371-2 · Cited by 782
Self-citationThe Mortality and Medical Costs of Air Pollution: Evidence from Changes in Wind Direction
Deryugina, T., Heutel, G., Miller, N. H., Molitor, D., & Reif, J. (2019) · American Economic Review · doi:10.1257/aer.20180279 · Cited by 771
Metadata
- Authors
- Brook, R. D., Urch, B., Dvonch, J. T., Bard, R. L., Speck, M., Keeler, G., Morishita, M., Marsik, F. J., Kamal, A. S., Kaciroti, N., Harkema, J., Corey, P., Silverman, F., Gold, D. R., Wellenius, G., Mittleman, M. A., Rajagopalan, S., & Brook, J. R.
- Venue
- Hypertension
- Published
- 2009-09
- Volume
- 54
- Issue
- 3
- Pages
- 659-667
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2109041140
- Cited by
- 484
- References
- 36
- FWCI
- 19.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Brook, R. D., Urch, B., Dvonch, J. T., Bard, R. L., Speck, M., Keeler, G., Morishita, M., Marsik, F. J., Kamal, A. S., Kaciroti, N., Harkema, J., Corey, P., Silverman, F., Gold, D. R., Wellenius, G., Mittleman, M. A., Rajagopalan, S., & Brook, J. R. (2009). Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans. Hypertension. https://doi.org/10.1161/hypertensionaha.109.130237
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
