The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Brain Microglial Cytokines in Neurogenic Hypertension
Open accessAbstract
Accumulating evidence indicates a key role of inflammation in hypertension and cardiovascular disorders. However, the role of inflammatory processes in neurogenic hypertension remains to be determined. Thus, our objective in the present study was to test the hypothesis that activation of microglial cells and the generation of proinflammatory cytokines in the paraventricular nucleus (PVN) contribute to neurogenic hypertension. Intracerebroventricular infusion of minocycline, an anti-inflammatory antibiotic, caused a significant attenuation of mean arterial pressure, cardiac hypertrophy, and plasma norepinephrine induced by chronic angiotensin II infusion. This was associated with decreases in the numbers of activated microglia and mRNAs for interleukin (IL) 1β, IL-6, and tumor necrosis factor-α, and an increase in the mRNA for IL-10 in the PVN. Overexpression of IL-10 induced by recombinant adenoassociated virus-mediated gene transfer in the PVN mimicked the antihypertensive effects of minocycline. Furthermore, acute application of a proinflammatory cytokine, IL-1β, into the left ventricle or the PVN in normal rats resulted in a significant increase in mean arterial pressure. Collectively, this indicates that angiotensin II induced hypertension involves activation of microglia and increases in proinflammatory cytokines in the PVN. These data have significant implications on the development of innovative therapeutic strategies for the control of neurogenic hypertension.
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Cites
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Microglia: activation and their significance in the central nervous system
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Self-citationBrain renin–angiotensin system dysfunction in hypertension: recent advances and perspectives
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Self-citationFerreira, A. J., Shenoy, V., Yamazato, Y., Sriramula, S., Francis, J., Yuan, L., Castellano, R. K., Ostrov, D. A., Oh, S. P., Katovich, M. J., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200811-1678oc · Cited by 245
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Self-citationTobramycin: A Review of its Antibacterial and Pharmacokinetic Properties and Therapeutic Use
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Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478
Self-citationThe gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753
Self-citationInflammation, Immunity, and Hypertensive End-Organ Damage
McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708
Wang, M., Pan, W., Xu, Y., Zhang, J., Wan, J., & Jiang, H. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s350109 · Cited by 461
Zhang, Z., Zhao, L., Zhou, X., Meng, X., & Zhou, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1098725 · Cited by 382
Metadata
- Authors
- Shi, P., Diez-Freire, C., Jun, J. Y., Qi, Y., Katovich, M. J., Li, Q., Sriramula, S., Francis, J., Sumners, C., & Raizada, M. K.
- Venue
- Hypertension
- Published
- 2010-08
- Volume
- 56
- Issue
- 2
- Pages
- 297-303
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2109011905
- Cited by
- 386
- References
- 28
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Shi, P., Diez-Freire, C., Jun, J. Y., Qi, Y., Katovich, M. J., Li, Q., Sriramula, S., Francis, J., Sumners, C., & Raizada, M. K. (2010). Brain Microglial Cytokines in Neurogenic Hypertension. Hypertension. https://doi.org/10.1161/hypertensionaha.110.150409
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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