The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Sympathetic Nervous System Activity Is Associated With Obesity-Induced Subclinical Organ Damage in Young Adults
Open accessAbstract
Excess weight is established as a major risk factor for cardiovascular diseases, particularly in young individuals. To get a better understanding of the pathophysiology underlying increased cardiovascular disease risk, we evaluated early signs of organ damage and their possible relationship to sympathetic nervous activity. Eighteen lean (body mass index <25 kg/m 2 ) and 25 overweight or obese (body mass index >25 kg/m 2 ) healthy university students were included in the study. We comprehensively assessed subclinical target organ damage, including the following: (1) assessment of renal function; (2) left ventricular structure and systolic and diastolic function; and (3) endothelial function. Muscle sympathetic nervous activity was assessed by microneurography. Participants with excess weight had decreased endothelial function ( P <0.01), elevated creatinine clearance ( P <0.05), increased left ventricular mass index ( P <0.05), increased left ventricular wall thickness ( P <0.01), lower systolic and diastolic function ( P <0.01), and elevated muscle sympathetic nervous activity ( P <0.001) compared with lean individuals. In multiple regression analysis, endothelial function was inversely related to muscle sympathetic nervous activity ( R 2 =0.244; P <0.05), whereas creatinine clearance and left ventricular mass index were positively related to muscle sympathetic nervous activity, after adjustment for body mass index, sex, and blood pressure ( R 2 =0.318, P <0.01 and R 2 =0.312, P <0.05, respectively). Excess weight in young individuals is associated with subclinical alterations in renal and endothelial function, as well as in the structure of the heart, even in the absence of hypertension. Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects.
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“Interestingly, sympathetic overdrive was also found to be closely related to subclinical cardiovascular and renal alterations that develop in obese subjects even in the absence of hypertension (19).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [19]
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Self-citationPatel, M., Braun, J., Keatch, C., Woods, W., Kameneva, T., & Lambert, É. (2025) · Clinical Autonomic Research · doi:10.1007/s10286-025-01173-1
Consequences of Arterial Switch Operation in Children Born with Transposition of the Great Arteries
Falkenberg, C. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Laugero, K. D., Snodgrass, R. G., & Keim, N. L. (2026) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2026.107655
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Okushi, Y., Takahashi, T., & Kusunose, K. (2026) · Journal of Echocardiography · doi:10.1007/s12574-026-00721-6
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Metadata
- Authors
- Lambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., Chopra, R., Wong, C., Chatzivlastou, K., Head, G., Straznicky, N., Esler, M., Schlaich, M., & Lambert, G.
- Affiliations
- From the Human Neurotransmitters (E.L., C.I.S., T.D., J.N., M.M., N.E., R.C., N.S., M.E., G.L.), Neurovascular Hypertension and Kidney Disease (M.S.), and Neuropharmacology (K.C., G.H.) Laboratories, Baker IDI Heart and Diabetes Institute, Heart Centre, Alfred Hospital (C.W.), and Faculty of Medicine, Nursing and Health Sciences (M.E., M.S., G.L.), and Departments of Physiology (E.L.) and Pharmacology (G.H.), Monash University, Melbourne, Victoria, Australia.
- Baker Heart and Diabetes Institute (AU)
- Venue
- Hypertension
- Published
- 2010-09
- Volume
- 56
- Issue
- 3
- Pages
- 351-358
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2156328907
- Cited by
- 209
- References
- 58
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 12 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 8 · 2017: 20 · 2016: 11 · 2015: 15 · 2014: 24 · 2013: 20 · 2012: 23
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart Foundation of Australia
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, sympathetic nervous system, muscle sympathetic nerve activity, subclinical organ damage, endothelial function, left ventricular hypertrophy, renal function, creatinine clearance, cardiovascular risk, young adults
- MeSH terms
- Adolescent, Adult, Endothelium, Vascular, Female, Heart, Humans, Hypertension, Kidney, Male, Obesity, Regression Analysis, Sympathetic Nervous System, Body Mass Index, Muscle, Skeletal, Statistics, Nonparametric, Overweight
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