The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Sympathetic Nervous System Activity Is Associated With Obesity-Induced Subclinical Organ Damage in Young Adults
Open accessAbstract
Excess weight is established as a major risk factor for cardiovascular diseases, particularly in young individuals. To get a better understanding of the pathophysiology underlying increased cardiovascular disease risk, we evaluated early signs of organ damage and their possible relationship to sympathetic nervous activity. Eighteen lean (body mass index <25 kg/m 2 ) and 25 overweight or obese (body mass index >25 kg/m 2 ) healthy university students were included in the study. We comprehensively assessed subclinical target organ damage, including the following: (1) assessment of renal function; (2) left ventricular structure and systolic and diastolic function; and (3) endothelial function. Muscle sympathetic nervous activity was assessed by microneurography. Participants with excess weight had decreased endothelial function ( P <0.01), elevated creatinine clearance ( P <0.05), increased left ventricular mass index ( P <0.05), increased left ventricular wall thickness ( P <0.01), lower systolic and diastolic function ( P <0.01), and elevated muscle sympathetic nervous activity ( P <0.001) compared with lean individuals. In multiple regression analysis, endothelial function was inversely related to muscle sympathetic nervous activity ( R 2 =0.244; P <0.05), whereas creatinine clearance and left ventricular mass index were positively related to muscle sympathetic nervous activity, after adjustment for body mass index, sex, and blood pressure ( R 2 =0.318, P <0.01 and R 2 =0.312, P <0.05, respectively). Excess weight in young individuals is associated with subclinical alterations in renal and endothelial function, as well as in the structure of the heart, even in the absence of hypertension. Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, sympathetic overdrive was also found to be closely related to subclinical cardiovascular and renal alterations that develop in obese subjects even in the absence of hypertension (19).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.
Devereux, R. B., & Reichek, N. (1977) · Circulation · doi:10.1161/01.cir.55.4.613 · Cited by 4,499
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687
The effect of age on the association between body-mass index and mortality
Stevens, J., Cai, J., Pamuk, E. R., Williamson, D. F., Thun, M. J., & Wood, J. L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801013380101 · Cited by 1,611
Sohn, D., Chai, I.-H., Lee, D., Kim, H. C., Kim, H.-S., Oh, B., Lee, M.-M., Park, Y.-B., Choi, Y., Seo, J. D., et al. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)88335-0 · Cited by 1,555
A Prospective Study of Obesity and Risk of Coronary Heart Disease in Women
Manson, J. E., Colditz, G. A., Stampfer, M. J., Willett, W. C., ROSNER, B. A., Monson, R. R., Speizer, F. E., & Hennekens, C. H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221303 · Cited by 1,403
Endothelial Function: A Critical Determinant in Atherosclerosis?
Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation · doi:10.1161/01.cir.0000129501.88485.1f · Cited by 851
Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
Kuvin, J. T., Patel, A. R., Sliney, K. A., Pandian, N. G., Sheffy, J., Schnall, R. P., Karas, R. H., & Udelson, J. E. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00094-2 · Cited by 772
Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis
Stern, M. P. (1995) · Diabetes · doi:10.2337/diab.44.4.369 · Cited by 739
Alterations of Left Ventricular Myocardial Characteristics Associated With Obesity
Wong, C. Y., O’Moore-Sullivan, T., Leano, R., Byrne, N., Beller, E., & Marwick, T. H. (2004) · Circulation · doi:10.1161/01.cir.0000147184.13872.0f · Cited by 713
Self-citationHamburg, N. M., Keyes, M. J., Larson, M. G., Vasan, R. S., Schnabel, R. B., Pryde, M. M., Mitchell, G. F., Sheffy, J., Vita, J. A., & Benjamin, E. J. (2008) · Circulation · doi:10.1161/circulationaha.107.748574 · Cited by 692
Rubinshtein, R., Kuvin, J. T., Soffler, M. I., Lennon, R. J., Lavi, S., Nelson, R. E., Pumper, G. M., Lerman, L. O., & Lerman, A. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq010 · Cited by 683
Obesity and risk for chronic renal failure.
Ejerblad, E., Fored, C. M., Lindblad, P., Fryzek, J., McLaughlin, J. K., & Nyren, O. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005060638 · Cited by 651
Sympathetic Activation in Obese Normotensive Subjects
Grassi, G., Seravalle, G., Cattaneo, B. M., Bolla, G. B., Lanfranchi, A., Colombo, M., Giannattasio, C., Brunani, A., Cavagnini, F., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.560 · Cited by 614
Sympathetic Neural Activation in Visceral Obesity
Alvarez, G. E., Beske, S. D., Ballard, T. P., & Davy, K. P. (2002) · Circulation · doi:10.1161/01.cir.0000041244.79165.25 · Cited by 557
Obesity and Obesity-Initiated Metabolic Syndrome
Wahba, I. M., & MAK, R. H. K. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04071206 · Cited by 524
Relation Between Cardiac Sympathetic Activity and Hypertensive Left Ventricular Hypertrophy
Schlaich, M. P., Kaye, D. M., Lambert, E., Sommerville, M., Socratous, F., & Esler, M. D. (2003) · Circulation · doi:10.1161/01.cir.0000081775.72651.b6 · Cited by 459
Self-citationAlterations in left ventricular structure and function in young healthy obese women
Peterson, L. R., Waggoner, A. D., Schechtman, K. B., Meyer, T., Gropler, R. J., Barzilai, B., & Dávila-Román, V. G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.062 · Cited by 449
Mechanisms of Sympathetic Activation in Obesity-Related Hypertension
Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443
Self-citationWang, M., Yip, G. W., Wang, A. Y.-M., Zhang, Y., Ho, P. Y., Tse, M. K., Lam, P. K. W., & Sanderson, J. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02921-2 · Cited by 428
Nagueh, S. F., Lakkis, N. M., Middleton, K. J., Franklin, J. L., & Spencer, W. H. (2004) · Circulation · doi:10.1161/01.cir.0000115644.35804.8b · Cited by 425
Sympathetic Activation in Chronic Renal Failure
Schlaich, M. P., Socratous, F., Hennebry, S., Eikelis, N., Lambert, E. A., Straznicky, N., Esler, M. D., & Lambert, G. W. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008040402 · Cited by 408
Self-citationRegional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects
Vaz, M., Jennings, G., Turner, A., Cox, H., Lambert, G., & Esler, M. (1997) · Circulation · doi:10.1161/01.cir.96.10.3423 · Cited by 404
Self-citationEffect of Age on Excess Mortality in Obesity
Bender, R. (1999) · JAMA · doi:10.1001/jama.281.16.1498 · Cited by 284
Glomerular hyperfiltration: A new marker of metabolic risk
Tomaszewski, M., Charchar, F. J., Maric, C., McClure, J., Crawford, L., Grzeszczak, W., Sattar, N. A., Zukowska-Szczechowska, E., & Dominiczak, A. F. (2007) · Kidney International · doi:10.1038/sj.ki.5002160 · Cited by 234
Straznicky, N. E., Lambert, E. A., Lambert, G. W., Masuo, K., Esler, M. D., & Nestel, P. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0961 · Cited by 227
Self-citationObesity and target organ damage: the kidney
for the PREVEND study group, Jong, P. D., Verhave, J. C., Pinto‐Sietsma, S., & Hillege, H. L. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802213 · Cited by 222
Drukteinis, J. S., Roman, M. J., Fabsitz, R. R., Lee, E. T., Best, L. G., Russell, M., & Devereux, R. B. (2007) · Circulation · doi:10.1161/circulationaha.106.668921 · Cited by 215
Grassi, G., Seravalle, G., Quarti-Trevano, F., Dell'Oro, R., Arenare, F., Spaziani, D., & Mancia, G. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.121467 · Cited by 194
Chagnac, A., Herman, M., Zingerman, B. V., Erman, A., Rozen‐Zvi, B., Hirsh, J., & Gafter, U. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn379 · Cited by 193
Delanaye, P., Radermecker, R. P., Rorive, M., Depas, G., & Krzesinski, J. M. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh983 · Cited by 190
Mechanisms of endothelial dysfunction in obesity.
Avogaro, A., & de Kreutzenberg, S. V. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.04.020 · Cited by 188
Prediction of Clinical Diabetic Nephropathy in IDDM Patients: Alternatives to Microalbuminuria?
Mogensen, C. E. (1990) · Diabetes · doi:10.2337/diab.39.7.761 · Cited by 168
Local mechanisms of blood flow control by perivascular nerves and endothelium.
Burnstock, G. (1990) · PubMed · Cited by 138
Endothelial dysfunction in obesity: etiological role in atherosclerosis
Meyers, M. R., & Gokce, N. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282be90a8 · Cited by 134
Gender differences in sympathetic nervous activity: influence of body mass and blood pressure
Lambert, É., Straznicky, N. E., Eikelis, N., Esler, M., Dawood, T., Masuo, K., Schlaich, M. P., & Lambert, G. W. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281053af4 · Cited by 123
Self-citationBurns, J., Sivananthan, M. U., Ball, S. G., Mackintosh, A. F., Mary, D. A. S. G., & Greenwood, J. P. (2007) · Circulation · doi:10.1161/circulationaha.106.668863 · Cited by 122
Straznicky, N. E., Lambert, É., Nestel, P. J., McGrane, M. T., Dawood, T., Schlaich, M. P., Masuo, K., Eikelis, N., de Courten, B. V., Mariani, J. A., et al. (2009) · Diabetes · doi:10.2337/db09-0934 · Cited by 118
Self-citationContribution of individual organs to total noradrenaline release in humans.
Esler, M., Jennings, G., Leonard, P., SACHARIAS, N., Burke, F., Johns, J., & Blombery, P. A. (1984) · PubMed · Cited by 114
Self-citationBjörn Folkow Award Lecture The sympathetic nervous system in hypertension
Mancia, G. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00056 · Cited by 107
Owlya, R., Vollenweider, L., Trueb, L., Sartori, C. S., Lepori, M., NICOD, P. H., & Scherrer, U. (1997) · Circulation · doi:10.1161/01.cir.96.11.3897 · Cited by 106
Insulin Resistance and Vascular Dysfunction in Nondiabetic Asian Indians
Raji, A., Gerhard-Herman, M. D., Warren, M., Silverman, S. G., Raptopoulos, V., Mantzoros, C. S., & Simonson, D. C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0087 · Cited by 98
Toprak, A. C., Wang, H., Chen, W., Paul, T. K., Srinivasan, S. R., & Berenson, G. S. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.01.045 · Cited by 98
Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats
Luippold, G. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg584 · Cited by 77
Skarphedinsson, J. O., Elam, M., Jungersten, L., & Wallin, B. G. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.671bm.x · Cited by 75
Charkoudian, N., Joyner, M. J., Barnes, S. A., Johnson, C. P., Eisenach, J. H., Dietz, N. M., & Wallin, B. G. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00234.2006 · Cited by 64
Norton, G. R., Maseko, M. J., Libhaber, E. N., Libhaber, C. D., Majane, O. H. I., Dessein, P. H., Sareli, P., & Woodiwiss, A. J. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e328311f296 · Cited by 61
Sverrisdóttir, Y. B., Jansson, L. M., Hägg, U., & Gan, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009257 · Cited by 58
Influences of Gender on the Interaction between Sympathetic Nerve Traffic and Central Adiposity
Tank, J., Heusser, K., Diedrich, A., Hering, D., Luft, F. C., Busjahn, A., Narkiewicz, K., & Jordan, J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2820 · Cited by 57
Cardiac Structure and Function in the Obese: A Cardiovascular Magnetic Resonance Imaging Study
Danias, P. G., Tritos, N. A., Stuber, M., Kissinger, K. V., Salton, C. J., & Manning, W. J. (2003) · Journal of Cardiovascular Magnetic Resonance · doi:10.1081/jcmr-120022259 · Cited by 50
The Effect of Moxonidine on Endothelial Dysfunction in Metabolic Syndrome
Topal, E., Çıkım, A. S., Çıkım, K., Temel, İ., & Оздемир, Р. (2006) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200606050-00007 · Cited by 40
&NA;, &. (1990) · Journal of Hypertension · doi:10.1097/00004872-199012000-00017 · Cited by 38
Siddiqi, L., Prakken, N. H. J., Velthuis, B. K., Cramer, M. J., Oey, P. L., de Boer, P., Bots, M. L., & Blankestijn, P. J. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq175 · Cited by 36
Levine, D. Z. (2007) · Clinical Science · doi:10.1042/cs20070088 · Cited by 34
Palatini, P., Majahalme, S. K., Amerena, J. V., Nesbitt, S. D., Vriz, O., Michieletto, M., Krause, L. C., & Julius, S. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018060-00016 · Cited by 27
[Arterial rigidity and endothelial dysfunction in obese children].
Aggoun, Y., Tounian, P., Dabbas, M., Massih, T. A., Girardet, J.-P., Ricour, C., Sidi, D., & Bonnet, D. (2002) · PubMed · Cited by 21
Blockade of the Renin-Angiotensin-Aldosterone System: Effects on Hypertensive Target Organ Damage
Grandi, A. M., & Maresca, A. M. (2006) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152506777698326 · Cited by 17
Metabolic syndrome and left ventricular dysfunction: New player of the game
Celık, T., Iyısoy, A., Yüksel, U. Ç., Jata, B., & Güngör, M. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.06.013 · Cited by 2
Cited by
Sorted by citations
Neurological consequences of obesity
O’Brien, P. D., Hinder, L. M., Callaghan, B. C., & Feldman, E. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30084-4 · Cited by 561
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274
Lambert, É. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00052 · Cited by 243
The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 259
Obesity and adipokines: effects on sympathetic overactivity
Smith, M. M., & Minson, C. T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.221036 · Cited by 245
Metadata
- Authors
- Lambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., Chopra, R., Wong, C., Chatzivlastou, K., Head, G., Straznicky, N., Esler, M., Schlaich, M., & Lambert, G.
- Affiliations
- From the Human Neurotransmitters (E.L., C.I.S., T.D., J.N., M.M., N.E., R.C., N.S., M.E., G.L.), Neurovascular Hypertension and Kidney Disease (M.S.), and Neuropharmacology (K.C., G.H.) Laboratories, Baker IDI Heart and Diabetes Institute, Heart Centre, Alfred Hospital (C.W.), and Faculty of Medicine, Nursing and Health Sciences (M.E., M.S., G.L.), and Departments of Physiology (E.L.) and Pharmacology (G.H.), Monash University, Melbourne, Victoria, Australia.
- Baker Heart and Diabetes Institute (AU)
- Venue
- Hypertension
- Published
- 2010-09
- Volume
- 56
- Issue
- 3
- Pages
- 351-358
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2156328907
- Cited by
- 209
- References
- 58
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 12 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 8 · 2017: 20 · 2016: 11 · 2015: 15 · 2014: 24 · 2013: 20 · 2012: 23
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart Foundation of Australia
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, sympathetic nervous system, muscle sympathetic nerve activity, subclinical organ damage, endothelial function, left ventricular hypertrophy, renal function, creatinine clearance, cardiovascular risk, young adults
- MeSH terms
- Adolescent, Adult, Endothelium, Vascular, Female, Heart, Humans, Hypertension, Kidney, Male, Obesity, Regression Analysis, Sympathetic Nervous System, Body Mass Index, Muscle, Skeletal, Statistics, Nonparametric, Overweight
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
