The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury
Open accessAbstract
Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II–induced hypertension and vascular injury. Ten- to 12-week–old male C57BL/6 mice were injected IV with 3×10 5 Treg (CD4 + CD25 + ) or T effector (CD4 + CD25 − ) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 μg/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg ( P <0.05), NADPH oxidase activity 1.5-fold in aorta and 1.8-fold in the heart ( P <0.05), impaired acetylcholine vasodilatory responses by 70% compared with control ( P <0.05), and increased vascular stiffness ( P <0.001), mesenteric artery vascular cell adhesion molecule expression (2-fold; P <0.05), and aortic macrophage and T-cell infiltration ( P <0.001). All of the above were prevented by Treg but not T effector adoptive transfer. Ang II caused a 43% decrease in Foxp3 + cells in the renal cortex, whereas Treg adoptive transfer increased Foxp3 + cells 2-fold compared with control. Thus, Tregs suppress Ang II–mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II–induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction.
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Cites
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736
Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes
Lindley, S., Dayan, C. M., Bishop, A., Roep, B. O., Peakman, M., & Tree, T. I. M. (2005) · Diabetes · doi:10.2337/diabetes.54.1.92 · Cited by 861
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T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
Jackson, S. H., Devadas, S., Kwon, J., Pinto, L. A., & Williams, M. S. (2004) · Nature Immunology · doi:10.1038/ni1096 · Cited by 457
Role of the renin–angiotensin system in vascular inflammation
Marchesi, C., Paradis, P., & Schiffrin, E. L. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.05.003 · Cited by 432
Self-citationDe Ciuceis, C., Amiri, F., Brassard, P., Endemann, D. H., Touyz, R. M., & Schiffrin, E. L. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000181743.28028.57 · Cited by 350
Self-citationRole of Naturally Occurring CD4 + CD25 + Regulatory T Cells in Experimental Atherosclerosis
Mor, A., Planer, D., Luboshits, G., Afek, A., Metzger, S., Chajek-Shaul, T., Keren, G., & George, J. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000259365.31469.89 · Cited by 348
Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.-K., Fischer, R., Schwarz, I., Rahn, H.-P., Plehm, R., Wellner, M., Elitok, S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.832782 · Cited by 339
Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
Akdis, C. A., & Akdis, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.02.030 · Cited by 337
Cited by
Inflammation, Immunity, and Hypertensive End-Organ Damage
McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708
The role of infiltrating immune cells in dysfunctional adipose tissue
Guzik, T. J., Skiba, D. S., Touyz, R. M., & Harrison, D. G. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx108 · Cited by 445
Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Karbach, S. H., Schönfelder, T., Brandão, I., Wilms, E., Hörmann, N., Jäckel, S., Schüler, R., Finger, S., Knorr, M., Lagrange, J., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003698 · Cited by 378
Type 2 Diabetes Mellitus and Hypertension
Lastra, G., Syed, S., Kurukulasuriya, L. R., Manrique, C., & Sowers, J. R. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.005 · Cited by 307
eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation
Karbach, S., Wenzel, P., Waisman, A., Munzel, T., & Daiber, A. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660748 · Cited by 307
Metadata
- Authors
- Barhoumi, T., Kasal, D. A., Li, M. W., Shbat, L., Laurant, P., Neves, M. F., Paradis, P., & Schiffrin, E. L.
- Venue
- Hypertension
- Published
- 2011-03
- Volume
- 57
- Issue
- 3
- Pages
- 469-476
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2167193994
- Cited by
- 459
- References
- 34
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Barhoumi, T., Kasal, D. A., Li, M. W., Shbat, L., Laurant, P., Neves, M. F., Paradis, P., & Schiffrin, E. L. (2011). T Regulatory Lymphocytes Prevent Angiotensin II–Induced Hypertension and Vascular Injury. Hypertension. https://doi.org/10.1161/hypertensionaha.110.162941
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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