Type 2 Diabetes Mellitus and Hypertension
Open accessAbstract
Patients with hypertension and type 2 diabetes are at increased risk of cardiovascular and chronic renal disease. Factors involved in the pathogenesis of both hypertension and type 2 diabetes include inappropriate activation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, impaired insulin-mediated vasodilatation, augmented sympathetic nervous system activation, altered innate and adaptive immunity, and abnormal sodium processing by the kidney. The renin-angiotensin-aldosterone system blockade is a key therapeutic strategy in the treatment of hypertension in type 2 diabetes. Emerging therapies for resistant hypertension as often exists in patients with diabetes, include renal denervation and carotid body denervation.
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Chronic NO deficiency in T2D results in a hyper-constricted state of the microvasculature, impairing delivery of oxygen and nutrients to tissues and contributing to diabetic neuropathies, poor exercise tolerance, and elevated blood pressure.
“Chronic NO-deficiency in T2D results in a hyper-constricted state of the microvasculature; therefore, the delivery of oxygen and nutrients to tissues is impaired, contributing to diabetic neuropathies and the poor exercise tolerance observed in patients, as well as elevated blood pressure.232,235,236”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [235]
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- Authors
- Lastra, G., Syed, S., Kurukulasuriya, L. R., Manrique, C., & Sowers, J. R.
- Affiliations
- Harry S. Truman Memorial Veterans' Hospital (US)
- University of Missouri (US)
- Corresponding author
- Sowers, James R.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 43
- Issue
- 1
- Pages
- 103-122
- ISSN
- 0889-8529 (ISSN-L)
- PMC
- PMC3942662
- OpenAlex
- W1511683349
- Cited by
- 307
- References
- 134
- Citations by year
- 2026: 9 · 2025: 29 · 2024: 27 · 2023: 31 · 2022: 45 · 2021: 44 · 2020: 37 · 2019: 29 · 2018: 21 · 2017: 9 · 2016: 7 · 2015: 14 · 2014: 4
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl107910-03)
- National Heart, Lung, and Blood Institute (R01 HL73101‑01A1, R01 HL 107910-01, R01-HL-107910, R01HL073101)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- type 2 diabetes, hypertension, cardiovascular risk, chronic kidney disease, renin-angiotensin-aldosterone system, oxidative stress, inflammation, insulin resistance, sympathetic activation, renin-angiotensin-aldosterone system blockade, resistant hypertension, renal denervation, carotid body denervation
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Hypertension, Comorbidity
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