Cited by 307Blood Pressure and Hypertension StudiesRenin-Angiotensin System StudiesChronic Kidney Disease and Diabetes

Type 2 Diabetes Mellitus and Hypertension

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Lastra, Guido, Syed, Sofia, Kurukulasuriya, L. Romayne, Manrique, Camila, Sowers, James R.·2014·Endocrinology and Metabolism Clinics of North America

Abstract

Patients with hypertension and type 2 diabetes are at increased risk of cardiovascular and chronic renal disease. Factors involved in the pathogenesis of both hypertension and type 2 diabetes include inappropriate activation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, impaired insulin-mediated vasodilatation, augmented sympathetic nervous system activation, altered innate and adaptive immunity, and abnormal sodium processing by the kidney. The renin-angiotensin-aldosterone system blockade is a key therapeutic strategy in the treatment of hypertension in type 2 diabetes. Emerging therapies for resistant hypertension as often exists in patients with diabetes, include renal denervation and carotid body denervation.

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Crossref · 10.1016/j.ecl.2013.09.005

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  • Chronic NO deficiency in T2D results in a hyper-constricted state of the microvasculature, impairing delivery of oxygen and nutrients to tissues and contributing to diabetic neuropathies, poor exercise tolerance, and elevated blood pressure.

    “Chronic NO-deficiency in T2D results in a hyper-constricted state of the microvasculature; therefore, the delivery of oxygen and nutrients to tissues is impaired, contributing to diabetic neuropathies and the poor exercise tolerance observed in patients, as well as elevated blood pressure.232,235,236”

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Research works printed but not linked: 2

  1. [59]ACCORD Study Group Cushman WC Evans GW Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010 362 1575 1585 20228401 PMC4123215
  2. [93]Ogihara T Nakao K Fukui T Candesartan Antihypertensive Survival Evaluation in Japan Trial Group. Effects of candesartan compared with amlodipine in hypertensive patients with high cardiovascular risks: candesartan antihypertensive survival evaluation in Japan trial. Hypertension 2008 51 393 398 18172059

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Authors
Lastra, G., Syed, S., Kurukulasuriya, L. R., Manrique, C., & Sowers, J. R.
Affiliations
  • Harry S. Truman Memorial Veterans' Hospital (US)
  • University of Missouri (US)
Corresponding author
Sowers, James R.
Venue
Endocrinology and Metabolism Clinics of North America
Publisher
Elsevier BV
Published
2014-03
Volume
43
Issue
1
Pages
103-122
ISSN
0889-8529 (ISSN-L)
OpenAlex
W1511683349
Cited by
307
References
134
Citations by year
2026: 9 · 2025: 29 · 2024: 27 · 2023: 31 · 2022: 45 · 2021: 44 · 2020: 37 · 2019: 29 · 2018: 21 · 2017: 9 · 2016: 7 · 2015: 14 · 2014: 4
FWCI
1.41
Type
journal article
Language
en
Open access
Locations
  • Endocrinology and Metabolism Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01hl107910-03)
  • National Heart, Lung, and Blood Institute (R01 HL73101‑01A1, R01 HL 107910-01, R01-HL-107910, R01HL073101)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
type 2 diabetes, hypertension, cardiovascular risk, chronic kidney disease, renin-angiotensin-aldosterone system, oxidative stress, inflammation, insulin resistance, sympathetic activation, renin-angiotensin-aldosterone system blockade, resistant hypertension, renal denervation, carotid body denervation
MeSH terms
Diabetes Mellitus, Type 2, Humans, Hypertension, Comorbidity

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