Relationships Between Selected Gene Polymorphisms and Blood Pressure Sensitivity to Weight Loss in Elderly Persons With Hypertension
Abstract
Salt sensitivity, the heterogeneity in the response of blood pressure (BP) to alterations in sodium intake, has been studied extensively, whereas weight sensitivity, the heterogeneity in BP response to weight change, has received scant attention. We examined the relationship of 21 gene polymorphisms previously found to be associated with hypertension, diabetes mellitus, or obesity, with weight sensitivity in the Trial of Nonpharmacologic Interventions in the Elderly, where participants with hypertension were randomized to receive intensive dietary intervention of sodium reduction, weight loss, both, or attention control, whereas pharmacological therapy was kept constant. After correcting for multiplicity, we identified significant associations of 3 polymorphisms with weight sensitivity of systolic BP (rs4646994, rs2820037, and rs1800629) and 3 polymorphisms for diastolic BP (rs4646994, rs2820037, and rs5744292). A recursive partitioning algorithm selected the combination of rs4646994, rs1800629, rs1982073, and rs1800896 as the set associated with the highest weight sensitivity. Polymorphisms related to hypertension, obesity, and diabetes mellitus are associated with weight sensitivity of BP.
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Patients carrying certain polymorphisms related to obesity and hypertension seem more likely to benefit from dietary interventions for weight loss and blood pressure control.
“This is based on the observation that patients carrying certain polymorphisms related to obesity and hypertension seems more likely to benefit from dietary interventions for weight loss and blood pressure control (12;13).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [13]
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- Authors
- Kostis, W. J., Cabrera, J., Hooper, W. C., Whelton, P. K., Espeland, M. A., Cosgrove, N. M., Cheng, J. Q., Deng, Y., De Staerck, C., Pyle, M., Maruthur, N., Reyes, I., Anderson, C. A. M., Liu, J., & Kostis, J. B.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- From the Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA (W.J.K.); Department of Statistics, Rutgers University, Piscataway, NJ (J.C., I.R., J.L.); Cardiovascular Institute, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ (J.C., N.M.C., J.Q.C., Y.D., J.B.K.); Centers for Disease Control and Prevention, Atlanta, GA (W.C.H., C.D.S., M.P.); Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (P.K.W.); Department of...
- ORCID
- Venue
- Hypertension
- Published
- 2013-04
- Volume
- 61
- Issue
- 4
- Pages
- 857-863
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2111238599
- Cited by
- 18
- References
- 35
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2020: 2 · 2018: 2 · 2015: 2 · 2014: 5 · 2013: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institutes of Health (CC999999)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- weight sensitivity, blood pressure, genetic polymorphism, older adults, sodium reduction, dietary intervention, weight loss, salt sensitivity, obesity, diabetes mellitus, rs4646994, rs1800629, rs1800896, genetic susceptibility
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Blood Pressure, Diet, Sodium-Restricted, Female, Follow-Up Studies, Genotype, Humans, Hypertension, Male, Middle Aged, Obesity, Polymorphism, Genetic, Sodium, Dietary, Weight Loss
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