Vitamin D, Parathyroid Hormone, and Sudden Cardiac Death: Results From the Cardiovascular Health Study
Open accessAbstract
Recent studies have demonstrated greater risks of cardiovascular events and mortality among persons who have lower 25-hydroxyvitamin D (25-OHD) and higher parathyroid hormone (PTH) levels. We sought to evaluate the association between markers of mineral metabolism and sudden cardiac death (SCD) among the 2312 participants from the Cardiovascular Health Study who were free of clinical cardiovascular disease at baseline. We estimated associations of baseline 25-OHD and PTH concentrations individually and in combination with SCD using Cox proportional hazards models after adjustment for demographics, cardiovascular risk factors, and kidney function. During a median follow-up of 14 years, there were 73 adjudicated SCD events. The annual incidence of SCD was greater among subjects who had lower 25-OHD concentrations, 2 events per 1000 for 25-OHD ≥20 ng/mL and 4 events per 1000 for 25-OHD <20 ng/mL. Similarly, SCD incidence was greater among subjects who had higher PTH concentrations, 2 events per 1000 for PTH <65 pg/mL and 4 events per 1000 for PTH ≥65 pg/mL. Multivariate adjustment attenuated associations of 25-OHD and PTH with SCD. Finally, 267 participants (11.7% of the cohort) had high PTH and low 25-OHD concentrations. This combination was associated with a >2-fold risk of SCD after adjustment (hazard ratio: 2.19 [95% CI: 1.17–4.10]; P =0.017) compared with participants with normal levels of PTH and 25-OHD. The combination of lower 25-OHD and higher PTH concentrations appears to be associated independently with SCD risk among older adults without cardiovascular disease.
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Cites
A Proportional Hazards Model for the Subdistribution of a Competing Risk
Fine, J. P., & Gray, R. J. (1999) · Journal of the American Statistical Association · doi:10.1080/01621459.1999.10474144 · Cited by 14,290 · see citing works
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works
Self-citationVitamin D Deficiency and Risk of Cardiovascular Disease
Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K. J., Benjamin, E. J., D’Agostino, R. B., Wolf, M. S., & Vasan, R. S. (2008) · Circulation · doi:10.1161/circulationaha.107.706127 · Cited by 2,394 · see citing works
Webb, A. R., KLINE, L., & Holick, M. F. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-373 · Cited by 1,661 · see citing works
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625 · see citing works
Calculating measures of biological interaction
Andersson, T., Alfredsson, L., Källberg, H., Zdravkovic, S., & Ahlbom, A. (2005) · European Journal of Epidemiology · doi:10.1007/s10654-005-7835-x · Cited by 1,498 · see citing works
25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population
Melamed, M. L., Michos, E. D., Post, W. S., & Astor, B. C. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1629 · Cited by 1,213 · see citing works
Dobnig, H. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.12.1340 · Cited by 1,209 · see citing works
Wood, R. J., Tchack, L., & Taparia, S. (2001) · BMC Physiology · doi:10.1186/1472-6793-1-11 · Cited by 852 · see citing works
Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults
Straus, S. M. J. M., Kors, J. A., De Bruin, M. L., van der Hooft, C. S., Hofman, A., Heeringa, J., Deckers, J. W., Kingma, J. H., Sturkenboom, M. C. J. M., Stricker, B. H. C., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.067 · Cited by 833 · see citing works
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death
Haider, A. W., Larson, M. G., Benjamin, E. J., & Levy, D. A. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00407-0 · Cited by 797 · see citing works
Serum vitamin D concentrations among elderly people in Europe
van der Wielen, R. P. J., de Groot, C. P. G. M., van Staveren, W. A., Löwik, M. R. H., van den Berg, H., Haller, J., & Moreiras, O. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91266-5 · Cited by 771 · see citing works
Sudden Cardiac Death Prediction and Prevention
Fishman, G. I., Chugh, S. S., Dimarco, J., Albert, C. M., Anderson, M. E., Bonow, R. O., Buxton, A. E., Chen, P., Estes, M., Jouven, X., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.976092 · Cited by 609 · see citing works
Self-citationPilz, S., März, W., Wellnitz, B., Seelhorst, U., Fahrleitner‐Pammer, A., Dimai, H. P., Boehm, B. O., & Dobnig, H. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0784 · Cited by 603 · see citing works
Algra, A., Tijssen, J. G. P., Roelandt, J. R. T. C., Pool, J., & Lubsen, J. C. (1991) · Circulation · doi:10.1161/01.cir.83.6.1888 · Cited by 591 · see citing works
Xiang, W., Kong, J., Chen, S., Cao, L., Qiao, G., Zheng, W., Liu, W., Li, X., Gardner, D. G., & Li, Y. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00224.2004 · Cited by 570 · see citing works
Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study
Psaty, B. M., Kuller, L. H., Bild, D. E., Burke, G. L., Kittner, S. J., Mittelmark, M. B., Price, T. R., Rautaharju, P. M., & Robbins, J. B. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(94)00092-8 · Cited by 446 · see citing works
Self-citationLaboratory methods and quality assurance in the Cardiovascular Health Study
Cushman, M., Cornell, E. S., Howard, P. R., Bovill, E. G., & Tracy, R. P. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.264 · Cited by 439 · see citing works
Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community
Hagström, E., Hellman, P., Larsson, T. E., Ingelsson, E., Berglund, L., Sundström, J., Melhus, H., Held, C., Lind, L., Michaëlsson, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.808733 · Cited by 416 · see citing works
Dawson‐Hughes, B., Harris, S., & Dallal, G. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.1.67 · Cited by 347 · see citing works
Krall, E. A., Sahyoun, N., Tannenbaum, S., Dallal, G. E., & Dawson-Hughes, B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912283212602 · Cited by 345 · see citing works
Bodyak, N. D., Ayus, J. C., Achinger, S. G., Venkatesha, S., Ke, Q., Chen, Y.-S., Rigor, D. L., Stillman, I. E., Tamez, H. E., Kroeger, P. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611202104 · Cited by 332 · see citing works
Wu, J., Garami, M., Cheng, T., & Gardner, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118582 · Cited by 257 · see citing works
Drechsler, C., Pilz, S., Obermayer-Pietsch, B. M., Verduijn, M., Tomaschitz, A., Krane, V., Espe, K. M., Dekker, F. W., Brandenburg, V. M., März, W., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq246 · Cited by 253 · see citing works
Vitamin D and vascular calcification
Zittermann, A., Schleithoff, S. S., & Koerfer, R. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328011c6fc · Cited by 204 · see citing works
When Throughout the Year Is Coronary Death Most Likely to Occur?
Kloner, R. A., Poole, W. K., & Perritt, R. L. (1999) · Circulation · doi:10.1161/01.cir.100.15.1630 · Cited by 199 · see citing works
1,25-dihydroxyvitamin D3 modulates growth of vascular smooth muscle cells.
Mitsuhashi, T., Morris, R. C., & Ives, H. E. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115213 · Cited by 179 · see citing works
Pilz, S., Tomaschitz, A., Drechsler, C., Ritz, E., Boehm, B. O., Grammer, T. B., & Marz, W. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq109 · Cited by 160 · see citing works
Weishaar, R. E., Kim, S. N., Saunders, D. E., et al. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.1.e134 · Cited by 154 · see citing works
Rashid, G., Bernheim, J., Green, J., & Benchetrit, S. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00406.2006 · Cited by 141 · see citing works
Kim, H. W., Park, C. W., Shin, Y. S., et al. (2005) · Nephron Clinical Practice · doi:10.1159/000088295 · Cited by 135 · see citing works
Perrier‐Groult, E., Kerfant, B., Lalevée, N., Bideaux, P., Rossier, M. F., Richard, S., Gomez, A. M., & Bénitah, J. (2004) · Circulation · doi:10.1161/01.cir.0000138973.55605.38 · Cited by 129 · see citing works
Parathyroid Hormone Has a Prosclerotic Effect on Vascular Smooth Muscle Cells
Perkovic, V., Hewitson, T. D., Kelynack, K. J., et al. (2003) · Kidney & Blood Pressure Research · doi:10.1159/000069761 · Cited by 124 · see citing works
Trophic effects of catecholamines and parathyroid hormone on adult ventricular cardiomyocytes
Schlüter, K., & Piper, H. M. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.6.h1739 · Cited by 123 · see citing works
β2-Adrenergic Receptor Genetic Variants and Risk of Sudden Cardiac Death
Sotoodehnia, N., Siscovick, D. S., Vatta, M., Psaty, B. M., Tracy, R. P., Towbin, J. A., Lemaître, R. N., Rea, T. D., Durda, J. P., Chang, J. M., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.582833 · Cited by 118 · see citing works
Self-citationAttenuation or absence of circadian and seasonal rhythms of acute myocardial infarction.
Sayer, J., Wilkinson, P., Ranjadayalan, K., Ray, S., Marchant, B., & Timmis, A. (1997) · Heart · doi:10.1136/hrt.77.4.325 · Cited by 92 · see citing works
Weekly and seasonal variation in the incidence of cardiac arrests
Pecková, M., Fahrenbruch, C. E., Cobb, L. A., & Hallstrom, A. P. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70507-7 · Cited by 90 · see citing works
Reinier, K., Dervan, C., Singh, T., Uy‐Evanado, A., Lai, S., Gunson, K., Jui, J., & Chugh, S. S. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.02.037 · Cited by 84 · see citing works
Daily and Seasonal Variation in Sudden Cardiac Death, Rochester, Minnesota, 1950-1975
Beard, C. M., Fuster, V., & Elveback, L. R. (1982) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)18965-9 · Cited by 36 · see citing works
Krall, E. A., Sahyoun, N., Tannenbaum, S., Dallal, G., & Dawson‐Hughes, B. (1990) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(90)90600-p · Cited by 30 · see citing works
Value of animal models for Chlamydia pneumoniae -related atherosclerosis
Fong, I. W. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70288-7 · Cited by 30 · see citing works
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Brown, J. M., Williams, J. S., Luther, J. M., Garg, R., Garza, A. E., Pojoga, L. H., Ruan, D. T., Williams, G. H., Adler, G. K., & Vaidya, A. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.01910 · Cited by 88 · see citing works
Vaidya, A., Sun, B., Larson, C., Forman, J. P., & Williams, J. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1156 · Cited by 68 · see citing works
Gambardella, J., De Rosa, M., Sorriento, D., Prevete, N., Fiordelisi, A., Ciccarelli, M., Trimarco, B., De Luca, N., & Iaccarino, G. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9582319 · Cited by 58 · see citing works
Interactions between adrenal-regulatory and calcium-regulatory hormones in human health
Brown, J. M., & Vaidya, A. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000062 · Cited by 39 · see citing works
Chang, W.-T., Wu, C.-H., Hsu, L.-W., Chen, P.-W., Yu, J.-R., Chang, C.-S., Tsai, W.-C., & Liu, P.-Y. (2017) · Scientific Reports · doi:10.1038/srep40996 · Cited by 27 · see citing works
- Authors
- Deo, R., Katz, R., Shlipak, M. G., Sotoodehnia, N., Psaty, B. M., Sarnak, M. J., Fried, L. F., Chonchol, M., de Boer, I. H., Enquobahrie, D., Siscovick, D., & Kestenbaum, B.
- Affiliations
- Tufts Medical Center (US)
- From the Section of Electrophysiology (R.D.), Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA; Collaborative Health Studies Coordinating Center (R.K.), Division of Cardiology (N.S.), Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services (B.M.P., D.E., D.S.), and Division of Nephrology and Kidney Research Institute (I.H.d.B., B.K.), University of Washington, Seattle, WA; General Internal Medicine Section (M.G.S.), Veterans...
- ORCID
- Venue
- Hypertension
- Published
- 2011-12
- Volume
- 58
- Issue
- 6
- Pages
- 1021-1028
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3337033
- OpenAlex
- W2136806600
- Cited by
- 107
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 15 · 2012: 12
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc085082-026, n01hc085081-021, n01hc045133-001, n01hc085079-024, n01hc015103-009, n01hc085084-005, n01hc085085-011, n01hc085083-027, n01hc085080-026, n01hc085086-022, 5kl2rr025015-02, n01hc55222-0-0-0, n01hc075150-004, n01hc035129-010)
- National Institute on Aging (R56AG023629, R01AG020098, R01-AG-15928, R01 AG20098, AG023629, AG027058, R01AG023629, R01AG015928, R01AG027058, P30AG024827)
- National Heart, Lung, and Blood Institute (N01-HC-85081, N01HC85085, N01 HC085086, N01HC-85083, N01 HC085079, R01HL088456, N01HC85082, N01HC‐75150, N01 HC85086, N01 HC035129, N01HC85080, N01 HC015103, N01HC80007, N01 HC55222, R01HL075366, U01HL080295, N01 HC055222, R01HL084443, N01 HC075150, N01 HC045133, N01-HC85079, N01-HC85084)
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK089118, P30DK035816)
- National Center for Research Resources (KL2-RR025015)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- vitamin D, 25-hydroxyvitamin D, parathyroid hormone, sudden cardiac death, mineral metabolism, cardiovascular risk, older adults, Cardiovascular Health Study, vitamin D deficiency
- MeSH terms
- Aged, Cardiovascular Diseases, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Hypertension, Kidney, Male, Middle Aged, Minerals, Parathyroid Hormone, Risk Factors, Socioeconomic Factors, United States, Vitamin D, Comorbidity, Incidence, Proportional Hazards Models, Death, Sudden, Cardiac
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