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Cited by 345Vitamin D Research StudiesParathyroid Disorders and TreatmentsBone health and osteoporosis research

Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women

Krall, Elizabeth A., Sahyoun, Nadine, Tannenbaum, Saul, Dallal, Gerard E., Dawson-Hughes, Bess·1989·New England Journal of Medicine
DOI 10.1056/nejm198912283212602
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Abstract

Vitamin D intake should be sufficient to maintain calcium absorption and prevent increased parathyroid secretion throughout the year. To determine the level of intake that achieved the latter in elderly women, we studied the interrelations among vitamin D intake, serum 25-hydroxyvitamin D (25(OH)D) levels, and parathyroid hormone concentrations in a cross-sectional study of 333 healthy, white, postmenopausal women with low median calcium (408 mg a day) and vitamin D (112 IU a day) intakes who lived in Massachusetts. The overall inverse relation between serum parathyroid hormone and 25(OH)D levels was found to be dependent on vitamin D intake. In women whose estimated intake of vitamin D was less than or equal to 220 IU a day, the mean (+/- SD) serum parathyroid hormone values were lowest in those studied between August and October (30 +/- 11 ng per liter; n = 72) and highest in those studied between March and May (37 +/- 16 ng per liter; n = 54); the respective serum 25(OH)D levels were 93 +/- 32 and 63 +/- 21 nmol per liter. At vitamin D intakes of more than 220 IU a day, the mean serum parathyroid hormone and 25(OH)D levels did not vary with the season. The correlation between vitamin D intake and serum 25(OH)D concentration, although significant in all women (r = 0.29; P less than 0.001), was highest in those studied between March and May (r = 0.65; P less than 0.001) and lowest in those studied between August and October (r = 0.13; P greater than 0.10). The estimated serum 25(OH)D level associated with a vitamin D intake of 220 IU a day between March and May was 95 nmol per liter. Mean serum calcium values were similar at all times in both groups. We conclude that the dietary intake of more than 220 IU of vitamin D a day by postmenopausal women in Massachusetts may be sufficient to maintain constant serum 25(OH)D and parathyroid hormone concentrations throughout the year. Such an intake prevents a seasonal increase in parathyroid hormone secretion, with its possible deleterious skeletal effects.

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Authors
Krall, E. A., Sahyoun, N., Tannenbaum, S., Dallal, G. E., & Dawson-Hughes, B.
Affiliations
Tufts University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1989-12-28
Volume
321
Issue
26
Pages
1777-1783
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198912283212602
OpenAlex
W1987770924
Cited by
345
References
37
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 13 · 2012: 3
FWCI
8.70
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
vitamin D intake, parathyroid hormone, 25-hydroxyvitamin D, seasonal variation, postmenopausal women, serum calcium, vitamin D sufficiency, parathyroid hormone secretion, bone health, older women, low calcium intake, vitamin D deficiency prevention
MeSH terms
Calcium, Calcium, Dietary, Cross-Sectional Studies, Dose-Response Relationship, Drug, Female, Humans, Hydroxycholecalciferols, Massachusetts, Menopause, Middle Aged, Parathyroid Hormone, Seasons, Vitamin D

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