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Cited by 65Sodium Intake and HealthBlood Pressure and Hypertension StudiesNutritional Studies and Diet

Mortality Benefits From US Population-wide Reduction in Sodium Consumption: Projections From 3 Modeling Approaches

Coxson, Pamela G., Cook, Nancy R., Joffres, Michel, Hong, Yuling, Orenstein, Diane, Schmidt, Steven M., Bibbins-Domingo, Kirsten·2013·Hypertension
DOI 10.1161/hypertensionaha.111.201293
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Abstract

Computer simulations have been used to estimate the mortality benefits from population-wide reductions in dietary sodium, although comparisons of these estimates have not been rigorously evaluated. We used 3 different approaches to model the effect of sodium reduction in the US population over the next 10 years, incorporating evidence for direct effects on cardiovascular disease mortality (method 1), indirect effects mediated by blood pressure changes as observed in randomized controlled trials of antihypertension medications (method 2), or epidemiological studies (method 3).The 3 different modeling approaches were used to model the same scenarios: scenario A, gradual uniform reduction totaling 40% over 10 years; scenario B, instantaneous 40% reduction in sodium consumption sustained for 10 years to achieve a population-wide mean of 2200 mg/d; and scenario C, instantaneous reduction to 1500 mg sodium per day sustained for 10 years. All 3 methods consistently show a substantial health benefit for reductions in dietary sodium under each of the 3 scenarios tested. A gradual reduction in dietary sodium over the next decade (scenario A) as might be achieved with a range of proposed public health interventions would yield considerable health benefits over the next decade, with mean effects across the 3 models ranging from 280 000 to 500 000 deaths averted. Projections of instantaneous reductions illustrate the maximum benefits that could be achieved (0.7-1.2 million deaths averted in 10 years). Under 3 different modeling assumptions, the projected health benefits from reductions in dietary sodium are substantial.

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Crossref · 10.1161/hypertensionaha.111.201293

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Authors
Coxson, P. G., Cook, N. R., Joffres, M., Hong, Y., Orenstein, D., Schmidt, S. M., & Bibbins-Domingo, K.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-03
Volume
61
Issue
3
Pages
564-570
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.111.201293
OpenAlex
W3214821180
Cited by
65
References
36
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 14 · 2013: 10 · 2012: 1
FWCI
10.47
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
dietary sodium reduction, cardiovascular mortality, blood pressure, antihypertensive drugs, public health interventions, computer simulation, United States population
MeSH terms
Adult, Aged, Aged, 80 and over, Antihypertensive Agents, Cardiovascular Diseases, Computer Simulation, Female, Forecasting, Humans, Hypertension, Male, Middle Aged, Models, Biological, Mortality, Sodium, Dietary, United States, Epidemiologic Studies, Randomized Controlled Trials as Topic

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