CoChat
Sign Up
Cited by 303Blood Pressure and Hypertension StudiesRenal and Vascular PathologiesCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Renal Hemodynamics and Renal Function After Catheter-Based Renal Sympathetic Denervation in Patients With Resistant Hypertension

Mahfoud, Felix, Cremers, Bodo, Janker, Julia, Link, Britta, Vonend, Oliver, Ukena, Christian, Linz, Dominik, Schmieder, Roland, Rump, Lars Christian, Kindermann, Ingrid, Sobotka, Paul Andrew, Krum, Henry, Scheller, Bruno, Schlaich, Markus, Laufs, Ulrich, Böhm, Michael·2012·Hypertension
DOI 10.1161/hypertensionaha.112.193870
Open this paper in CoChat — free account

Abstract

Increased renal resistive index and urinary albumin excretion are markers of hypertensive end-organ damage and renal vasoconstriction involving increased sympathetic activity. Catheter-based sympathetic renal denervation (RD) offers a new approach to reduce renal sympathetic activity and blood pressure in resistant hypertension. The influence of RD on renal hemodynamics, renal function, and urinary albumin excretion has not been studied. One hundred consecutive patients with resistant hypertension were included in the study; 88 underwent interventional RD and 12 served as controls. Systolic, diastolic, and pulse pressure, as well renal resistive index in interlobar arteries, renal function, and urinary albumin excretion, were measured before and at 3 and 6 months of follow-up. RD reduced systolic, diastolic, and pulse pressure at 3 and 6 months by 22.7/26.6 mm Hg, 7.7/9.7 mm Hg, and 15.1/17.5 mm Hg ( P for all <0.001), respectively, without significant changes in the control group. SBP reduction after 6 months correlated with SBP baseline values ( r =−0.46; P <0.001). There were no renal artery stenoses, dissections, or aneurysms during 6 months of follow-up. Renal resistive index decreased from 0.691±0.01 at baseline to 0.674±0.01 and 0.670±0.01 ( P =0.037/0.017) at 3- and 6-month follow-up. Mean cystatin C glomerular filtration rate and urinary albumin excretion remained unchanged after RD; however, the number of patients with microalbuminuria or macroalbuminuria decreased. RD reduced blood pressure, renal resistive index, and incidence of albuminuria without adversely affecting glomerular filtration rate or renal artery structure within 6 months and appears to be a safe and effective therapeutic approach to lower blood pressure in patients with resistant hypertension.

Overview

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.112.193870

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 33 references

Cited by

Sorted by citations

See all 303

Related

Metadata

Authors
Mahfoud, F., Cremers, B., Janker, J., Link, B., Vonend, O., Ukena, C., Linz, D., Schmieder, R., Rump, L. C., Kindermann, I., Sobotka, P. A., Krum, H., Scheller, B., Schlaich, M., Laufs, U., & Böhm, M.
Affiliations
Baker Heart and Diabetes Institute (AU)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-08
Volume
60
Issue
2
Pages
419-424
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.112.193870
OpenAlex
W2122826224
Cited by
303
References
33
Citations by year
2026: 5 · 2025: 4 · 2024: 4 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 14 · 2017: 18 · 2016: 31 · 2015: 39 · 2014: 56 · 2013: 83 · 2012: 11
FWCI
38.90
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Nephrology › Renal and Vascular Pathologies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
renal denervation, resistant hypertension, renal hemodynamics, renal resistive index, urinary albumin excretion, albuminuria, glomerular filtration rate, cystatin C, blood pressure reduction, interlobar arteries, renal vasoconstriction, hypertensive end-organ damage
MeSH terms
Albuminuria, Blood Pressure, Drug Resistance, Female, Follow-Up Studies, Glomerular Filtration Rate, Hemodynamics, Humans, Hypertension, Kidney, Kidney Function Tests, Male, Middle Aged, Sympathectomy, Incidence, Treatment Outcome, Cystatin C, Catheters

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review