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Cited by 517

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Prognostic Effect of the Nocturnal Blood Pressure Fall in Hypertensive Patients: The Ambulatory Blood Pressure Collaboration in Patients With Hypertension (ABC-H) Meta-Analysis

Salles, Gil F., Reboldi, Gianpaolo, Fagard, Robert H., Cardoso, Claudia R.L., Pierdomenico, Sante D., Verdecchia, Paolo, Eguchi, Kazuo, Kario, Kazuomi, Hoshide, Satoshi, Polonia, Jorge, de la Sierra, Alejandro, Hermida, Ramon C., Dolan, Eamon, O’Brien, Eoin, Roush, George C.·2016·Hypertension

Abstract

The prognostic importance of the nocturnal systolic blood pressure (SBP) fall, adjusted for average 24-hour SBP levels, is unclear. The Ambulatory Blood Pressure Collaboration in Patients With Hypertension (ABC-H) examined this issue in a meta-analysis of 17 312 hypertensives from 3 continents. Risks were computed for the systolic night-to-day ratio and for different dipping patterns (extreme, reduced, and reverse dippers) relative to normal dippers. ABC-H investigators provided multivariate adjusted hazard ratios (HRs), with and without adjustment for 24-hour SBP, for total cardiovascular events (CVEs), coronary events, strokes, cardiovascular mortality, and total mortality. Average 24-hour SBP varied from 131 to 140 mm Hg and systolic night-to-day ratio from 0.88 to 0.93. There were 1769 total CVEs, 916 coronary events, 698 strokes, 450 cardiovascular deaths, and 903 total deaths. After adjustment for 24-hour SBP, the systolic night-to-day ratio predicted all outcomes: from a 1-SD increase, summary HRs were 1.12 to 1.23. Reverse dipping also predicted all end points: HRs were 1.57 to 1.89. Reduced dippers, relative to normal dippers, had a significant 27% higher risk for total CVEs. Risks for extreme dippers were significantly influenced by antihypertensive treatment ( P <0.001): untreated patients had increased risk of total CVEs (HR, 1.92), whereas treated patients had borderline lower risk (HR, 0.72) than normal dippers. For CVEs, heterogeneity was low for systolic night-to-day ratio and reverse/reduced dipping and moderate for extreme dippers. Quality of included studies was moderate to high, and publication bias was undetectable. In conclusion, in this largest meta-analysis of hypertensive patients, the nocturnal BP fall provided substantial prognostic information, independent of 24-hour SBP levels.

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Metadata

Authors
Salles, G. F., Reboldi, G., Fagard, R. H., Cardoso, C. R. L., Pierdomenico, S. D., Verdecchia, P., Eguchi, K., Kario, K., Hoshide, S., Polonia, J., de la Sierra, A., Hermida, R. C., Dolan, E., O’Brien, E., & Roush, G. C.
Venue
Hypertension
Published
2016-04
Volume
67
Issue
4
Pages
693-700
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
OpenAlex
W2275906638
Cited by
517
References
42
FWCI
40.84
Type
journal article
Language
en
Open access
closed

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Salles, G. F., Reboldi, G., Fagard, R. H., Cardoso, C. R. L., Pierdomenico, S. D., Verdecchia, P., Eguchi, K., Kario, K., Hoshide, S., Polonia, J., de la Sierra, A., Hermida, R. C., Dolan, E., O’Brien, E., & Roush, G. C. (2016). Prognostic Effect of the Nocturnal Blood Pressure Fall in Hypertensive Patients: The Ambulatory Blood Pressure Collaboration in Patients With Hypertension (ABC-H) Meta-Analysis. Hypertension. https://doi.org/10.1161/hypertensionaha.115.06981

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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