Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs
Open accessAbstract
BACKGROUND: Obesity-induced hypertension appears to be due, in part, to increased renal sympathetic activity. Catheter-based renal denervation (RD) has been reported to lower arterial blood pressure (BP) in humans with resistant hypertension, many of whom are obese. This study was performed to assess the impact of radiofrequency-induced RD on renal function, BP, renal norepinephrine (NE), and histology of nerves along the renal artery in obese, hypertensive dogs, an experimental model that closely mimics cardiorenal and metabolic changes in obese hypertensive humans. METHODS: After control measurements of cardiovascular and renal function were obtained in obese dogs fed a high-fat diet, bilateral RD was performed using the St. Jude Medical EnligHTN RD system. After RD, BP was measured continuously for 8 weeks, and glomerular filtration rate (GFR) was measured biweekly for 6 weeks. At the end of the study, renal arteries were collected for histological analysis, and kidneys were obtained for NE measurement. RESULTS: Eight weeks after RD, systolic BP fell from 157 ± 5 mm Hg pre-RD to 133 ± 3 mm Hg (P < 0.01), and mean arterial pressure decreased by 9 mm Hg compared with pre-RD (P < 0.01). There were no significant changes in GFR. Renal nerve injury was most prevalent 0.28-3.5mm from the renal artery lumen. RD caused injury in 46% of the renal nerves observed and reduced renal tissue NE by 42% (P < 0.01). CONCLUSIONS: Catheter-based RD with the St. Jude Medical EnligHTN system lowers BP in obese dogs without significantly compromising renal function.
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Increased renal sympathetic nerve activity in individuals with obesity contributes to increases in renin secretion, sodium reabsorption and blood pressure.
“Increased RSNA in individuals with obesity contributes to increases in renin secretion, sodium reabsorption and BP159–161.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [161]
Partial renal denervation using a catheter-based radiofrequency method reduced renal noradrenaline levels by only about 42% but substantially decreased blood pressure in obese dogs.
“Moreover, partial RDN, using a catheter-based radiofrequency method, reduced renal noradrenaline levels by only ~42% but substantially decreased BP in obese dogs161.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [161]
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- Authors
- Henegar, J. R., Zhang, Y., Rama, R. D., Hata, C., Hall, M. E., & Hall, J. E.
- Affiliations
- University of Mississippi Medical Center (US)
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-06
- Volume
- 27
- Issue
- 10
- Pages
- 1285-1292
- ISSN
- 0895-7061 (ISSN-L)
- 1941-7225
- PMC
- PMC4184388
- OpenAlex
- W1963919923
- Cited by
- 89
- References
- 29
- Citations by year
- 2024: 5 · 2023: 5 · 2022: 1 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 18 · 2015: 16 · 2014: 7
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- St. Jude Medical
- National Heart, Lung, and Blood Institute (P01HL051971)
- National Institute of General Medical Sciences (P20GM104357)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- renal denervation, radiofrequency ablation, obesity-related hypertension, blood pressure reduction, renal sympathetic nerves, norepinephrine, glomerular filtration rate, renal function, resistant hypertension, canine model
- MeSH terms
- Animals, Blood Pressure, Disease Models, Animal, Dogs, Glomerular Filtration Rate, Hypertension, Kidney, Male, Norepinephrine, Obesity, Sympathectomy, Sympathetic Nervous System, Catheter Ablation, Diet, High-Fat
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