Cited by 109Birth, Development, and HealthPregnancy and preeclampsia studiesGestational Diabetes Research and Management

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Developmental and Early Life Origins of Cardiometabolic Risk Factors: Novel Findings and Implications

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Lurbe, Empar, Ingelfinger, Julie·2021·Hypertension

DOI 10.1161/hypertensionaha.120.14592

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Abstract

The intent of this review is to critically consider the data that support the concept of programming and its implications. Birth weight and growth trajectories during childhood are associated with cardiometabolic disease in adult life. Both extremes, low and high birth weight coupled with postnatal growth increase the early presence of cardiometabolic risk factors and vascular imprinting, crucial elements of this framework. Data coming from epigenetics, proteomics, metabolomics, and microbiota added relevant information and contribute to better understanding of mechanisms as well as development of biomarkers helping to move forward to take actions. Research has reached a stage in which sufficiently robust data calls for new initiatives focused on early life. Prevention starting early in life is likely to have a very large impact on reducing disease incidence and its associated effects at the personal, economic, and social levels.

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Additional file 3 of Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways
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Self-citation
Additional file 2 of Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways
Alba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623115
Self-citation
Additional file 5 of Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways
Alba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623124
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Additional file 4 of Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways
Alba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623121
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Additional file 1 of Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways
Alba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623112
Self-citation
Additional file 6 of The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089071
Additional file 3 of The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089062
Additional file 5 of The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089068
Additional file 1 of The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089050
Additional file 2 of The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089056
Additional file 1 of The association of gestational age and birthweight with blood pressure, cardiac structure, and function in 4 years old: a prospective birth cohort study
Du, B., Wang, H., Wu, Y., Li, Z., Niu, Y., Wang, Q., Zhang, L., Chen, S., Wu, Y., Huang, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22625834
Additional file 4 of The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089065
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Authors: Lurbe, E., & Ingelfinger, J.
Affiliations: Universitat de València (ES)
Harvard University (US)
ORCID: Lurbe, Empar
Ingelfinger, Julie
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2021-02
Volume: 77
Issue: 2
Pages: 308-318
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.120.14592
OpenAlex: W3120874154
Cited by: 106
References: 90
Citations by year: 2026: 18 · 2025: 26 · 2024: 19 · 2023: 26 · 2022: 13 · 2021: 4
FWCI: 4.00
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: developmental origins of health and disease, cardiometabolic risk factors, birth weight, epigenetics, microbiota, metabolomics, proteomics, biomarkers
MeSH terms: Adverse Childhood Experiences, Adolescent, Adult, Aging, Birth Weight, Cardiovascular Diseases, Cardiovascular System, Child, Child, Preschool, Female, Forecasting, Gestational Age, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Male, Metabolic Diseases, Middle Aged, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Proteomics, Epigenesis, Genetic, Metabolomics, Precision Medicine, Epigenomics, Microbiota

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Developmental and Early Life Origins of Cardiometabolic Risk Factors: Novel Findings and Implications

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