The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease
Open accessAbstract
Epidemiological studies have documented that insulin resistance and diabetes not only constitute metabolic abnormalities but also predispose to hypertension, vascular stiffness, and associated cardiovascular disease. Meanwhile, excessive arterial stiffness and impaired vasorelaxation, in turn, contribute to worsening insulin resistance and the development of diabetes. Molecular mechanisms promoting hypertension in diabetes include inappropriate activation of the renin-angiotensin-aldosterone system and sympathetic nervous system, mitochondria dysfunction, excessive oxidative stress, and systemic inflammation. This review highlights recent studies which have uncovered new underlying mechanisms for the increased propensity for the development of hypertension in association with diabetes. These include enhanced activation of epithelial sodium channels, alterations in extracellular vesicles and their microRNAs, abnormal gut microbiota, and increased renal sodium-glucose cotransporter activity, which collectively predispose to hypertension in association with diabetes. This review also covers socioeconomic factors and currently recommended blood pressure targets and related treatment strategies in diabetic patients with hypertension.
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Cited by
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
Osset-Malla, M., Martínez-Velasco, A., Sánchez-Benavides, G., Buongiorno, M., de la Sierra, A., Shekari, M., Minguillon, C., Kollmorgen, G., Quijano-Rubio, C., Zetterberg, H., et al. (2025) · The Journal of Prevention of Alzheimer's Disease · doi:10.1016/j.tjpad.2025.100304 · Cited by 8
Metadata
- Authors
- Jia, G., & Sowers, J. R.
- Venue
- Hypertension
- Published
- 2021-11
- Volume
- 78
- Issue
- 5
- Pages
- 1197-1205
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W3204320219
- Cited by
- 428
- References
- 71
- FWCI
- 30.70
- Type
- journal article
- Language
- en
- Open access
- green
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