Blood Pressure and White-Matter Disease Progression in a Biethnic Cohort: Atherosclerosis Risk in Communities (ARIC) Study
Open accessAbstract
Background and Purpose— Blood pressure (BP) is a predictor of concurrent and subsequently measured white-matter hyperintensity (WMH), but longitudinal studies of WMH changes and data in black participants are lacking. We hypothesized that WMH progression would be (1) strongly related to BP in blacks and whites and (2) predicted more strongly by earlier (midlife) or cumulative BP measurements than by measures at older ages. Methods— Participants were 983 individuals (49% black) from the Atherosclerosis Risk in Communities (ARIC) Study who underwent cerebral magnetic resonance imaging in 1993–1995 and 2004–2006. Associations between BP (measured at each of 5 visits, in addition to a time-averaged cumulative BP) and progression of WMHs were analyzed and compared. Results— Cumulative systolic BP (SBP) was the strongest BP predictor of WMH progression in adjusted models. Higher cumulative SBP (by 20 mm Hg) was associated with greater progression of WMHs and was similar in blacks (2.5 cm 3 , P <0.0001) and whites (2.6 cm 3 , P <0.0001). Higher cumulative SBP (per 20 mm Hg) was also associated with being in the top quintile of WMH progression (adjusted odds ratio=2.0; 95% CI, 1.6 to 2.6). Earlier SBP measurements were stronger predictors of WMH progression than were later SBP measurements, but in blacks only. Conclusions— In this population-based cohort, cumulative SBP was a stronger predictor of WMH progression than SBP from individual visits, in both blacks and whites. Earlier BPs were stronger predictors than BPs measured at later time points in blacks only.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hypertension is a key risk factor for WMH, but its relationship with blood pressure is complex.
“Hypertension is a key risk factor for WMH79-83 but the relationship with blood pressure (BP) is complex.”
From Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging (2013) · cites this paper as [83]
Effective antihypertensive treatment is associated with reduced progression of WMH in observational studies.
“Effective antihypertensive treatment is associated with reduced progression of WMH in observational studies.79,80,83”
From Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging (2013) · cites this paper as [83]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
THE ARIC INVESTIGATORS (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115184 · Cited by 3,491 · see citing works
(1989) · PubMed · Cited by 3,139 · see citing works
Longstreth, W. T., Manolio, T. A., Arnold, A., Burke, G. L., Bryan, N., Jungreis, C. A., Enright, P. L., O'Leary, D., & Fried, L. (1996) · Stroke · doi:10.1161/01.str.27.8.1274 · Cited by 1,464 · see citing works
The Association Between Midlife Blood Pressure Levels and Late-Life Cognitive Function
Launer, L. J. (1995) · JAMA · doi:10.1001/jama.1995.03530230032026 · Cited by 944 · see citing works
Tobin, M. D., Sheehan, N. A., Scurrah, K. J., & Burton, P. R. (2005) · Statistics in Medicine · doi:10.1002/sim.2165 · Cited by 695 · see citing works
van Dijk, E. J., Prins, N. D., Vrooman, H. A., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2008) · Stroke · doi:10.1161/strokeaha.107.513176 · Cited by 580 · see citing works
Stroke Risk Profile Predicts White Matter Hyperintensity Volume: The Framingham Study
Jeerakathil, T., Wolf, P. A., Beiser, A., Massaro, J., Seshadri, S., D’Agostino, R. B., & DeCarli, C. (2004) · Stroke · doi:10.1161/01.str.0000135226.53499.85 · Cited by 479 · see citing works
Manolio, T. A., Kronmal, R. A., Burke, G. L., Poirier, V. C., O’Leary, D. H., Gardin, J. M., Fried, L. P., Steinberg, E. P., & Bryan, R. N. (1994) · Stroke · doi:10.1161/01.str.25.2.318 · Cited by 457 · see citing works
Liao, D., Cooper, L. S., Cai, J., Toole, J. F., Bryan, R. N., Hutchinson, R. G., & Tyroler, H. A. (1996) · Stroke · doi:10.1161/01.str.27.12.2262 · Cited by 450 · see citing works
Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD
Yoshita, M., Fletcher, E., Harvey, D., Ortega, M., Martinez, O., Mungas, D. M., Reed, B. R., & DeCarli, C. S. (2006) · Neurology · doi:10.1212/01.wnl.0000249119.95747.1f · Cited by 434 · see citing works
Association of midlife blood pressure to late-life cognitive decline and brain morphology
Swan, G. E., DeCarli, C. S., Miller, B. L., Reed, T., Wolf, P. A., Jack, L. M., & Carmelli, D. (1998) · Neurology · doi:10.1212/wnl.51.4.986 · Cited by 388 · see citing works
Small Vessel Disease and General Cognitive Function in Nondisabled Elderly
van der Flier, W. M., van Straaten, E. C. W., Barkhof, F., Verdelho, A., Madureira, S., Pantoni, L., Inzitari, D., Erkinjuntti, T., Crisby, M., Waldemar, G., et al. (2005) · Stroke · doi:10.1161/01.str.0000179092.59909.42 · Cited by 324 · see citing works
Change in Blood Pressure and Incident Dementia
Stewart, R. J., Xue, Q., Masaki, K., Petrovitch, H., Ross, G. W., White, L. R., & Launer, L. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.128744 · Cited by 206 · see citing works
Adult-derived neural precursors transplanted into multiple regions in the adult brain
Herrera, D. G., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199912)46:6 · Cited by 204 · see citing works
Cerebral MRI findings and cognitive functioning
Mosley, T. H., Knopman, D. S., Catellier, D., Bryan, N., Hutchinson, R. G., Grothues, C. A., Folsom, A. R., Cooper, L. S., Burke, G. L., Liao, D., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000165985.97397.88 · Cited by 173 · see citing works
Self-citationVariability in Midlife Systolic Blood Pressure Is Related to Late-Life Brain White Matter Lesions
Havlik, R. J., Foley, D. J., Sayer, B., Masaki, K., White, L. R., & Launer, L. J. (2002) · Stroke · doi:10.1161/hs0102.101890 · Cited by 162 · see citing works
Midlife Pulse Pressure and Incidence of Dementia
Freitag, M., Peila, R., Masaki, K., Petrovitch, H., Ross, G. W., White, L. R., & Launer, L. J. (2005) · Stroke · doi:10.1161/01.str.0000196941.58869.2d · Cited by 154 · see citing works
Prevalence and determinants of subclinical brain infarction: The Northern Manhattan Study
Prabhakaran, S., Wright, C. B., Yoshita, M., Delapaz, R., Brown, T., DeCarli, C., & Sacco, R. L. (2008) · Neurology · doi:10.1212/01.wnl.0000277521.66947.e5 · Cited by 151 · see citing works
Inflammation and white matter damage in vascular cognitive impairment
Rosenberg, G. A. (2009) · Stroke · doi:10.1161/strokeaha.108.533133 · Cited by 149 · see citing works
Cognitive impairment risk: White matter hyperintensity progression matters
Silbert, L. C., Howieson, D. B., Dodge, H., & Kaye, J. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181ad53fd · Cited by 123 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
Wardlaw, J. M., Smith, C., & Dichgans, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70060-7 · Cited by 1,657 · see citing works
White matter hyperintensities, cognitive impairment and dementia: an update
Prins, N. D., & Scheltens, P. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.10 · Cited by 1,284 · see citing works
Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
Debette, S., Seshadri, S., Beiser, A., Au, R., Himali, J. J., Palumbo, C., Wolf, P. A., & DeCarli, C. (2011) · Neurology · doi:10.1212/wnl.0b013e318227b227 · Cited by 772 · see citing works
Iadecola, C., Yaffe, K., Biller, J., Bratzke, L. C., Faraci, F. M., Gorelick, P. B., Gulati, M., Kamel, H., Knopman, D. S., Launer, L. J., et al. (2016) · Hypertension · doi:10.1161/hyp.0000000000000053 · Cited by 746 · see citing works
Self-citationWhite matter hyperintensities: relationship to amyloid and tau burden
Graff-Radford, J., Arenaza-Urquijo, E. M., Knopman, D. S., Schwarz, C. G., Brown, R. D., Rabinstein, A. A., Gunter, J. L., Senjem, M. L., Przybelski, S. A., Lesnick, T., et al. (2019) · Brain · doi:10.1093/brain/awz162 · Cited by 253 · see citing works
Self-citationLane, C. A., Barnes, J., Nicholas, J. M., Sudre, C. H., Cash, D. M., Parker, T. D., Malone, I. B., Lu, K., James, S.-N., Keshavan, A., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30228-5 · Cited by 247 · see citing works
Vascular inflammation in cerebral small vessel disease
Rouhl, R. P. W., Damoiseaux, J. G. M. C., Lodder, J., Theunissen, R. O. M. F. I. H., Knottnerus, I. L. H., Staals, J., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Tervaert, J. W. C., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.04.008 · Cited by 219 · see citing works
Godin, O., Tzourio, C., Maillard, P., Mazoyer, B., & Dufouil, C. (2011) · Circulation · doi:10.1161/circulationaha.110.961052 · Cited by 187 · see citing works
Weber, R., Weimar, C., Blatchford, J., Hermansson, K., Wanke, I., Möller-Hartmann, C., Gizewski, E. R., Forsting, M., Demchuk, A. M., Sacco, R. L., et al. (2012) · Stroke · doi:10.1161/strokeaha.111.648576 · Cited by 82 · see citing works
Marcus, J., Gardener, H., Rundek, T., Elkind, M. S. V., Sacco, R. L., DeCarli, C., & Wright, C. B. (2011) · Stroke · doi:10.1161/strokeaha.111.617571 · Cited by 79 · see citing works
Association of hospitalization with long-term cognitive and brain MRI changes in the ARIC cohort
Brown, C. H., Sharrett, A. R., Coresh, J., Schneider, A. L. C., Alonso, A., Knopman, D. S., Mosley, T. H., & Gottesman, R. F. (2015) · Neurology · doi:10.1212/wnl.0000000000001439 · Cited by 42 · see citing works
Self-citationThe association between white matter hyperintensities and amyloid and tau deposition
Alban, S. L., Lynch, K. M., Ringman, J. M., Toga, A. W., Chui, H. C., Sepehrband, F., & Choupan, J. (2023) · NeuroImage: Clinical · doi:10.1016/j.nicl.2023.103383 · Cited by 35 · see citing works
Healthy heart, healthy brain: hypertension affects cognitive functioning in older age
Scullin, M. K., Le, D. T., & Shelton, J. T. (2017) · Translational Issues in Psychological Science · doi:10.1037/tps0000131 · Cited by 11 · see citing works
- Authors
- Gottesman, R. F., Coresh, J., Catellier, D. J., Sharrett, A. R., Rose, K. M., Coker, L. H., Shibata, D. K., Knopman, D. S., Jack, C. R., & Mosley, T. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- Stroke
- Published
- 2010-01
- Volume
- 41
- Issue
- 1
- Pages
- 3-8
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC2803313
- OpenAlex
- W1976312033
- Cited by
- 173
- References
- 20
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 13 · 2023: 6 · 2022: 13 · 2021: 9 · 2020: 12 · 2019: 17 · 2018: 15 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 16 · 2013: 9 · 2012: 6
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
- National Heart, Lung, and Blood Institute (N01-HC55022, N01 HC055016, R01 HL70825, N01-HC-55018, N01 HC 55020, N01 HC 55019, N01 HC055020, N01 HC055018, N01-HC55016, N01 HC055022, N01 HC055019, R01HL070825, N01‐HC‐55015, N01-HC55021, N01 HC055021, N01 HC055015)
- Topics
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- blood pressure, white matter hyperintensities, midlife blood pressure, racial differences, Black participants, cerebral small vessel disease, Atherosclerosis Risk in Communities Study
- MeSH terms
- Aged, Blood Pressure, Ethnicity, Female, Humans, Hypertension, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Prospective Studies, Residence Characteristics, Risk Factors, Cohort Studies, Disease Progression, Black People, White People, Leukoaraiosis, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
