The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease
Open accessAbstract
Disruptions of the blood–brain barrier (BBB) and edema formation both play key roles in the development of neurological dysfunction in acute and chronic cerebral ischemia. Animal studies have revealed the molecular cascades that are initiated with hypoxia/ischemia in the cells forming the neurovascular unit and that contribute to cell death. Matrix metalloproteinases cause reversible degradation of tight junction proteins early after the onset of ischemia, and a delayed secondary opening during a neuroinflammatory response occurring from 24 to 72 hours after. Cyclooxygenases are important in the delayed opening as the neuroinflammatory response progresses. An early opening of the BBB within the 3-hour therapeutic window for tissue-type plasminogen activator can allow it to enter the brain and increase the risk of hemorrhage. Chronic hypoxic hypoperfusion opens the BBB, which contributes to the cognitive changes seen with lacunar strokes and white matter injury in subcortical ischemic vascular disease. This review will describe the molecular and cellular events associated with BBB disruption and potential therapies directed toward restoring the integrity of the neurovascular unit.
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Cites
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661
Pericytes are required for blood–brain barrier integrity during embryogenesis
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Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage
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Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
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Self-citationFernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587
Lacunar stroke is associated with diffuse blood-brain barrier dysfunction
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Blood-brain barrier permeability abnormalities in vascular cognitive impairment
Taheri, S., Gasparovic, C., Huisa, B. N., Adair, J. C., Edmonds, E., Prestopnik, J., Grossetete, M., Shah, N. J., Wills, J., Qualls, C., et al. (2011) · Stroke · doi:10.1161/strokeaha.110.611731 · Cited by 248
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Cited by
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857
Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609
Delayed neurological deterioration after subarachnoid haemorrhage
Macdonald, R. L. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.246 · Cited by 887
Functional morphology of the blood–brain barrier in health and disease
Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872
Immune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853
Metadata
- Authors
- Yang, Y., & Rosenberg, G. A.
- Venue
- Stroke
- Published
- 2011-11
- Volume
- 42
- Issue
- 11
- Pages
- 3323-3328
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2162189519
- Cited by
- 789
- References
- 13
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- green
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