The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
The Effect of Cingulate Cortex Lesions on Task Switching and Working Memory
Abstract
Anatomic interconnections between the prefrontal and anterior cingulate cortices suggest that these areas may have similar functions. Here we report the effect of anterior cingulate removal on task switching, error monitoring, and working memory. Neuroimaging studies have implicated the cingulate cortex in all these processes. Six macaques were taught task switching (TS) and delayed alternation (DA) paradigms. TS required switching between two conditional response tasks with mutually incompatible response selection rules. DA required alternation between two identically covered food-well positions. In the first set of experiments, anterior cingulate lesions did not consistently impair TS or DA performance. One animal performed worst on both TS and DA and in this animal the cingulate sulcus lesion was most complete. In the second set of experiments, we confirmed that larger anterior cingulate lesions, which included the sulcus, consistently impaired TS but only led to a mild and equivocal impairment of DA. The TS error pattern, however, did not suggest an impairment of TS per se. The consequence of a cingulate lesion is, therefore, distinct to that of a prefrontal lesion. TS error distribution analyses provided some support for a cingulate role in monitoring responses for errors and subsequent correction but the pattern of reaction time change in TS was also indicative of a failure to sustain attention to the task and the responses being made.
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“In other reports, delayed alternation was spared, even though the anterior cingulate gyrus lesions again consistently involved the cingulum bundle (Rushworth et al., 2003).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Rushworth et al., 2003
Citations
Cites
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“It is also consistent with the claim that quite limited areas of cingulate damage can lead to impairment on Stroop tasks (Turken & Swick, 1999) and response reversal tasks (Paus et al., 1991; Paus, 2001) in some patients but not in others (Janer & Pardo, 1991).”
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Research works printed but not linked: 1
- 10.1073/pnas.060588897 · DOI · Paper page
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A Core System for the Implementation of Task Sets
Dosenbach, N. U. F., Visscher, K. M., Palmer, E. D., Miezin, F. M., Wenger, K. K., Kang, H. C., Burgund, E. D., Grimes, A. L., Schlaggar, B. L., & Petersen, S. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.031 · Cited by 1,772
Action sets and decisions in the medial frontal cortex
RUSHWORTH, M., WALTON, M., KENNERLEY, S., & BANNERMAN, D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.009 · Cited by 1,004
Self-citationOptimal decision making and the anterior cingulate cortex
Kennerley, S. W., Walton, M. E., Behrens, T. E. J., Buckley, M. J., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1724 · Cited by 948
Self-citationThe cingulate cortex and limbic systems for emotion, action, and memory
Rolls, E. T. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01945-2 · Cited by 859
The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740
“In other reports, delayed alternation was spared, even though the anterior cingulate gyrus lesions again consistently involved the cingulum bundle (Rushworth et al., 2003).”
Metadata
- Authors
- Rushworth, M. F. S., Hadland, K. A., Gaffan, D., & Passingham, R. E.
- Affiliations
- University of Oxford (GB)
- ORCID
- Rushworth, M. F. S.
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2003-04-01
- Volume
- 15
- Issue
- 3
- Pages
- 338-353
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2068032563
- Cited by
- 138
- References
- 92
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 5 · 2012: 12
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- anterior cingulate cortex, cingulate sulcus, task switching, working memory, error monitoring, delayed alternation, prefrontal cortex, lesion effects, macaque, attentional control, error correction
- MeSH terms
- Animals, Gyrus Cinguli, Macaca, Memory, Memory, Short-Term, Psychomotor Performance
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