Power in Voxel-based lesion-symptom mapping
Open accessAbstract
Lesion analysis in brain-injured populations complements what can be learned from functional neuroimaging. Voxel-based approaches to mapping lesion-behavior correlations in brain-injured populations are increasingly popular, and have the potential to leverage image analysis methods drawn from functional magnetic resonance imaging. However, power is a major concern for these studies, and is likely to vary regionally due to the distribution of lesion locations. Here, we outline general considerations for voxel-based methods, characterize the use of a nonparametric permutation test adapted from functional neuroimaging, and present methods for regional power analysis in lesion studies.
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It is difficult to determine which part of the lesion site is driving observed behavioural effects.
“In all cases, it is therefore difficult to determine which part of the lesion site is driving the observed behavioural effects”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Kimberg et al., 2007
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“, 2007), although with greater power for detecting effects in regions with greater lesion overlap (Kimberg et al., 2007).”
BackgroundMethodInfluential
- Authors
- Kimberg, D. Y., Coslett, H. B., & Schwartz, M. F.
- Affiliations
- University of Pennsylvania (US)
- Moss Rehabilitation Hospital (US)
- ORCID
- Coslett, H. Branch
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press
- Published
- 2007-07-01
- Volume
- 19
- Issue
- 7
- Pages
- 1067-1080
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2014076973
- Cited by
- 297
- References
- 48
- Citations by year
- 2026: 17 · 2025: 9 · 2024: 9 · 2023: 17 · 2022: 17 · 2021: 19 · 2020: 12 · 2019: 19 · 2018: 16 · 2017: 26 · 2016: 19 · 2015: 25 · 2014: 22 · 2013: 15 · 2012: 15
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
- repository.upenn.edu
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- ScholarlyCommons (University of Pennsylvania) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH073529)
- National Institute on Drug Abuse (R01DA014418)
- National Institute on Deafness and Other Communication Disorders (R01DC000191)
- National Institute of Neurological Disorders and Stroke (P30NS045839)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD050836)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- voxel-based lesion-symptom mapping, statistical power, brain injury, functional neuroimaging
- MeSH terms
- Brain Injuries, Brain Mapping, Cerebral Cortex, Humans, Functional Laterality, Magnetic Resonance Imaging, Signal Processing, Computer-Assisted, Statistics as Topic, Databases, Factual
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