Role of the precentral gyrus of the insula in complex articulation
Abstract
Previous research has suggested that the left anterior insula, specifically the superior precentral gyrus of the insula (SPGI), is a critical brain region for the coordination of complex articulatory movements. However, previous studies have not determined which articulatory factors are specifically dependent on this brain region. In the current study, 33 left hemisphere stroke patients with varying degrees of speech impairment were asked to perform multiple repetitions of single words that varied along three separate dimensions: number of syllables, degree of articulatory travel (i.e., change between places of articulation for consonants), and presence/absence of an initial consonant cluster. The role of the SPGI in performance across the three conditions was determined using voxel-based lesion symptom mapping (VLSM), a statistical approach to lesion analysis that does not require separating patients based on lesion site or symptom profile. Rather, continuous performance data are entered, along with lesions reconstructed in normalized space. Based on preliminary analyses, there was adequate power to detect differences in the SPGI, which was the focus of our predictions. We found that the SPGI was critical for performance on the articulation task across all three conditions, namely, when words were multi-syllabic, required a high degree of travel, or involved an initial consonant cluster. As a control, we also generated a VLSM map for articulation of words with minimal articulatory complexity (i.e., single-syllable words with no initial cluster and a minimal change in place of articulation). In this case, the SPGI was not implicated. The current results suggest that the left SPGI is a critical area for intra- and inter-syllabic coordination of complex articulatory movements, prior to end-stage execution of speech commands.
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Damage to each of the selected white/grey matter regions has been associated with speech production impairments in prior lesion studies.
“Damage to each of these white/grey matter regions has been associated with speech production impairments in prior lesion studies”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Baldo et al., 2011
Damage to both banks of the superior central sulcus centred at MNI coordinates [−36, 1, 10] has consistently been associated with speech production impairments after stroke.
“damage to both banks of the superior central sulcus centred at MNI coordinates [−36, 1, 10] has consistently been associated with speech production impairments after stroke”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Baldo et al., 2011
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- Authors
- Baldo, J. V., Wilkins, D. P., Ogar, J., Willock, S., & Dronkers, N. F.
- Affiliations
- VA Northern California Health Care System (US)
- University of California, San Francisco (US)
- University of California San Diego (US)
- Corresponding author
- Baldo, Juliana V.
- Venue
- Cortex
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 47
- Issue
- 7
- Pages
- 800-807
- ISSN
- 0010-9452 (ISSN-L)
- OpenAlex
- W1974164522
- Cited by
- 175
- References
- 41
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 44 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 13 · 2017: 8 · 2016: 13 · 2015: 11 · 2014: 15 · 2013: 8 · 2012: 10
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (5 R01DC00216, R01DC000216)
- National Institute of Neurological Disorders and Stroke (P01NS040813)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Keywords
- anterior insula, speech articulation, stroke, speech disorders, voxel-based lesion-symptom mapping, syllable number, consonant clusters, place of articulation, left hemisphere, speech motor control
- MeSH terms
- Aged, Aphasia, Brain Mapping, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Speech, Speech Production Measurement, Stroke
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