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Cited by 62Electrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applicationsTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Controlled Release of PDGF-bb by Coaxial Electrospun Dextran/Poly(L-lactide-co-ε-caprolactone) Fibers with an Ultrafine Core/Shell Structure

Li, Hua, Zhao, Chenguang, Wang, Zhexiang, Zhang, Hong, Yuan, Xiaoyan, Kong, Deling·2010·Journal of Biomaterials Science, Polymer Edition
DOI 10.1163/156856209x445302
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Abstract

Membranes composed of dextran (DEX) and poly(L-lactide-co-epsilon-caprolactone) (PLCL) as ultrafine core/shell fibers for loading platelet-derived growth factor-bb (PDGF-bb) were produced by coaxial electrospinning. The morphology and core/shell structure of the DEX/PLCL fibers containing PDGF-bb were investigated by scanning electron microscopy and transmission electron microscopy. The loading amount of PDGF-bb in the DEX/PLCL membrane prepared at 0.1 ml/h of the inner solution flow rate (DEX/PLCL-1P) was much lower than that in DEX/PLCL-2P and DEX/PLCL-3P obtained at 0.2 ml/h and 0.3 ml/h inner solution flow rate, respectively. All three membranes showed obvious burst release of PDGF-bb in the first 2 days, and then the release behaviors were smoother and steadier. They all kept a fibrous morphology during the whole release period of 28 days. Studies on adhesion, proliferation and morphology of the vascular smooth muscle cells on the fibrous membranes of DEX/PLCL-1P, DEX/PLCL-2P and DEX/PLCL-3P, as well as PLCL and DEX/PLCL suggested that DEX/PLCL membranes containing PDGF-bb protected in the core of ultrafine fibers could positively promote cell attachment, and their cell activities were significantly higher than those of PLCL and DEX/PLCL membranes without PDGF-bb. The DEX/PLCL-2P membrane with fine core/shell structure of fibers would be the best choices for further applications.

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Crossref · 10.1163/156856209x445302

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31 of 31 references verified0 citation errors · 0 not checkable

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  • PDGF-bb loaded in DEX/PLCL fibers shows continuous and stable release curve during subsequent 28-day release cycle after initial 2-day burst release, and promotes adhesion growth of vascular smooth muscle cells.

    “The results showed that PDGF-bb loaded in DEX/PLCL fibers showed a continuous and stable release curve during the subsequent 28-day release cycle after the initial 2-day burst release. The adhesion growth of vascular smooth muscle cells cultured on the surface of the fibers was promoted [221].”

    From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [221]

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Metadata

Authors
Li, H., Zhao, C., Wang, Z., Zhang, H., Yuan, X., & Kong, D.
Affiliations
  • Tianjin University (CN)
  • Nankai University (CN)
ORCID
Venue
Journal of Biomaterials Science, Polymer Edition
Publisher
Informa UK Limited
Published
2010-01
Volume
21
Issue
6-7
Pages
803-819
ISSN
  • 0920-5063 (ISSN-L)
  • 1568-5624
DOI
10.1163/156856209x445302
OpenAlex
W2036730884
Cited by
62
References
31
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 11 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 7
FWCI
2.37
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Biomaterials Science Polymer Edition (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
PDGF-BB, controlled release, coaxial electrospinning, core-shell fibers, dextran, poly(L-lactide-co-ε-caprolactone), ultrafine fibers, burst release, vascular smooth muscle cells, cell adhesion, cell proliferation, fibrous membranes
MeSH terms
Becaplermin, Animals, Biocompatible Materials, Cell Adhesion, Cell Survival, Cells, Cultured, Delayed-Action Preparations, Dextrans, Male, Platelet-Derived Growth Factor, Polyesters, Rats, Wistar, Proto-Oncogene Proteins c-sis, Myocytes, Smooth Muscle, Rats

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