Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system
Abstract
pH-Sensitive dextran hydrogels were prepared by activation of dextran (T-70) with 4-nitrophenyl chloroformate, followed by conjugation of the activated dextran with 4-aminobutyric acid and cross-linking with 1,10-diaminodecane. The cross-linking efficiencies determined by mechanical measurements were in the range of 52-63%. Incorporation of carboxylpropyl groups in dextran hydrogels led to a higher equilibrium and faster swelling under high pH conditions. The swelling reversibility of hydrogels was also observed after repeated changes in buffers between pH 2.0 and 7.4. The slow rates of swelling and deswelling in response to changes in pH were attributed to the hydrophilic nature of dextran and formation of hydrogen bonds between the hydroxyl groups of dextran with water molecules. The pronounced effect of carboxylic acid content on degradation of hydrogels was observed after 4 h of incubation with dextranase and the influence significantly decreased after exposure to the enzyme for 8 h. The mechanism of bulk degradation of hydrogels under high swelling extent was substantiated using Coomassie blue protein assay. The release rate of bovine serum albumin from hydrogels was primarily determined by the swelling extent. The release rate was further enhanced by addition of dextranase in buffer solutions.
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Dextran is an exceptional carrier matrix for drug release in the colon as the enzyme dextranase breaks the 1,6-glycosidic bond of dextran and breaks down the hydrogel matrix.
“Dextran is an exceptional carrier matrix for drug release in the colon as the enzyme dextranase breaks the 1,6-glycosidic bond of dextran and breaks down the hydrogel matrix (Hovgaard and Brøndsted, 1995; Simonsen et al., 1995; Chiu et al., 1999).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Chiu et al., 1999
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pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery.
Vegad, U., Patel, M., Khunt, D., Zupančič, O., Chauhan, S., & Paudel, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1270364 · Cited by 85 · see citing works
“Dextran is an exceptional carrier matrix for drug release in the colon as the enzyme dextranase breaks the 1,6-glycosidic bond of dextran and breaks down the hydrogel matrix (Hovgaard and Brøndsted, 1995; Simonsen et al., 1995; Chiu et al., 1999).”
Background
- Authors
- Chiu, H.-C., Hsiue, G.-H., Lee, Y.-P., & Huang, L.-W.
- Affiliations
- National Chung Hsing University (TW)
- Venue
- Journal of Biomaterials Science Polymer Edition
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 10
- Issue
- 5
- Pages
- 591-608
- ISSN
- 0920-5063 (ISSN-L)
- 1568-5624
- OpenAlex
- W2121999736
- Cited by
- 88
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomaterials Science Polymer Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- pH-responsive hydrogels, dextran hydrogels, colon-targeted drug delivery, swelling kinetics, bovine serum albumin release, controlled drug release
- MeSH terms
- Colonic Diseases, Dextrans, Dose-Response Relationship, Drug, Humans, Hydrogen-Ion Concentration, Kinetics, Serum Albumin, Bovine, Time Factors, Drug Delivery Systems, Hydrogel, Polyethylene Glycol Dimethacrylate
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