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Cited by 246Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsDrug Solubulity and Delivery Systems

Dextran hydrogels for colon-specific drug delivery

Hovgaard, Lars, Brøndsted, Helle·1995·Journal of Controlled Release
DOI 10.1016/0168-3659(95)00049-e
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Crossref · 10.1016/0168-3659(95)00049-e

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Dextran is an exceptional carrier matrix for drug release in the colon as the enzyme dextranase breaks the 1,6-glycosidic bond of dextran and breaks down the hydrogel matrix.

    “Dextran is an exceptional carrier matrix for drug release in the colon as the enzyme dextranase breaks the 1,6-glycosidic bond of dextran and breaks down the hydrogel matrix (Hovgaard and Brøndsted, 1995; Simonsen et al., 1995; Chiu et al., 1999).”

    From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Hovgaard and Brøndsted, 1995

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Authors
Hovgaard, L., & Brøndsted, H.
Affiliations
University of Copenhagen (DK)
Corresponding author
Hovgaard, Lars
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
1995-09
Volume
36
Issue
1-2
Pages
159-166
ISSN
0168-3659 (ISSN-L)
DOI
10.1016/0168-3659(95)00049-e
OpenAlex
W2040189760
Cited by
246
References
1
Citations by year
2026: 5 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 14 · 2016: 7 · 2015: 9 · 2014: 18 · 2013: 8 · 2012: 12
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
Journal of Controlled Release (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
dextran hydrogels, colon-targeted drug delivery, dextranase, hydrogel degradation, colonic fermentation, swelling ratio, mechanical strength, controlled drug release, cecum

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