The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Pandemic 2009 Influenza A in Argentina: A Study of 337 Patients on Mechanical Ventilation
Abstract
Rationale: The rapid spread of the 2009 Influenza A (H1N1) around the world underscores the need for a better knowledge of epidemiology, clinical features, outcomes, and mortality predictors, especially in the most severe presentations. Objectives: To describe these characteristics in patients with confirmed, probable, and suspected viral pneumonia caused by 2009 influenza A (H1N1) admitted to 35 intensive care units with acute respiratory failure requiring mechanical ventilation in Argentina, between June 3 and September 7. Methods: Inception-cohort study including 337 consecutive adult patients. Data were collected in a form posted on the Argentinian Society of Intensive Care website. Measurements and Main Results: Proportions of confirmed, probable, or suspected cases were 39%, 8%, and 53% and had similar outcomes. APACHE II was 18 ± 7; age 47 ± 17 years; 56% were male; and 64% had underlying conditions, with obesity (24%), chronic obstructive respiratory disease (18%), and immunosupression (15%) being the most common. Seven percent were pregnant. On admission, patients had severe hypoxemia (PaO2/FiO2 140 [87–200]), extensive lung radiologic infiltrates (2.87 ± 1.03 quadrants) and bacterial coinfection, (25%; mostly with Streptococcus pneumoniae). Use of adjuvants such as recruitment maneuvers (40%) and prone positioning (13%), and shock (72%) and acute kidney injury requiring hemodialysis (17%), were frequent. Mortality was 46%, and was similar across all ages. APACHE II, lowest PaO2/FiO2, shock, hemodialysis, prone positioning, and S. pneumoniae coinfection independently predicted death. Conclusions: Patients with 2009 influenza A (H1N1) requiring mechanical ventilation were mostly middle-aged adults, often with comorbidities, and frequently developed severe acute respiratory distress syndrome and multiorgan failure requiring advanced organ support. Case fatality rate was accordingly high.
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In the citing paper
“S.pneumoniae co-infection was associated with higher mortality (OR 2.72 95% CI 1.05–7.06), despite concurrent antibiotic treatment on admission [5].”
From The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09. (2018) · cites this paper as [5]
In the citing paper
“In a large study involving admissions to 35 ICUs for ILI and ARF requiring mechanical ventilation in Argentina (n = 337), 24% of included patients had bacterial pneumonia on admission, 8% with S. pneumoniae [5].”
From The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09. (2018) · cites this paper as [5]
In the citing paper
“Evidence of influenza predisposing to bacterial co-infection is seen in seasonal influenza epidemics, past pandemics, pathology studies and animal models [1–8].”
From The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09. (2018) · cites this paper as [5]
In the citing paper
“However, two early reviews of severe cases of 2009 pandemic influenza A (H1N1) showed no evidence of bacterial pneumonia among 30 hospitalized patients with laboratory-confirmed cases in California (5) and 10 intensive-care patients in Michigan (6).”
From The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09. (2018) · cites this paper as [5]
Citations
Cites
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746
An Expanded Definition of the Adult Respiratory Distress Syndrome
Murray, J. F., Matthay, M. A., Luce, J. M., & Flick, M. R. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.3.720 · Cited by 2,641
Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
Jain, S., Kamimoto, L., Bramley, A. M., Schmitz, A. M., Benoit, S. R., Louie, J., Sugerman, D. E., Druckenmiller, J. K., Ritger, K. A., Chugh, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906695 · Cited by 1,700
1918 Influenza: the Mother of All Pandemics
Taubenberger, J. K., & Morens, D. M. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1201.050979 · Cited by 1,686
1918 Influenza: the Mother of All Pandemics
Taubenberger, J. K., & Morens, D. M. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1209.05-0979 · Cited by 1,590
Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
The Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators* (2009) · JAMA · doi:10.1001/jama.2009.1535 · Cited by 1,585
Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada
Kumar, A. (2009) · JAMA · doi:10.1001/jama.2009.1496 · Cited by 1,425
H1N1 2009 influenza virus infection during pregnancy in the USA
Jamieson, D. J., Honein, M. A., Rasmussen, S. A., Williams, J. L., Swerdlow, D. L., Biggerstaff, M., Lindstrom, S., Louie, J. K., Christ, C. M., Bohm, S. R., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61304-0 · Cited by 1,350
Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Quiñones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904252 · Cited by 1,325
Research works printed but not linked: 8
- 2009, MMWR Morb Mortal Wkly Rep, 58, 1
- 2009, Crit Care Med, 38(4 Suppl), 133
- 2009, MMWR Morb Mortal Wkly Rep, 58, 1
- 2009, Nature, 20, 1021
- 2010, Am J Respir Crit Care Med, 18, 72
- 2009, Crit Care Med., 38(4 Suppl), 91
- 2010, Am J Respir Crit Care Med, 181, 1
- 2009, Medicina (B Aires), 69, 393
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Li, H., Wu, X., Zeng, H., Chang, B., Cui, Y., Zhang, J., Wang, R., & Ding, T. (2024) · Figshare · doi:10.6084/m9.figshare.26606047
Li, H., Wu, X., Zeng, H., Chang, B., Cui, Y., Zhang, J., Wang, R., & Ding, T. (2024) · Figshare · doi:10.6084/m9.figshare.26606050
Evaluation de stratégies thérapeutiques dans des modèles murins de pneumonie
Hraiech, S. (2014) · theses.fr (ABES) · doi:10.70675/872ddfa5zde9bz46a3z9771zb20c29f9a732
Bott, H., Pei, R., Murphy, M. E., Shi, T., & Ho, A. Y. W. (2026) · medRxiv · doi:10.64898/2026.04.29.26352034 · Cited by 1
Olgemöller, U., Becker, C., & Harnisch, L.-O. (2026) · Pneumologie · doi:10.1055/a-2867-9658
Zhihao, 列. L., Hu, Y., Chen, J., Lai, Z., Fang, Z., Huizhong, L. I. U., Liang, J., Zeng, Z., & Yang, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-11092290/v1
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Metadata
- Authors
- Estenssoro, E., Ríos, F. G., Apezteguía, C., Reina, R., Neira, J., Ceraso, D. H., Orlandi, C., Valentini, R., Tiribelli, N., Brizuela, M., Balasini, C., Mare, S., Domeniconi, G., Ilutovich, S., Gómez, A., Giuliani, J., Barrios, C., & Valdez, P.
- Affiliations
- Hospital Interzonal San Martin de La Plata, Buenos Aires, Argentina
- Hospital Posadas (AR)
- Sanatorio de la Trinidad-Palermo, Buenos Aires, Argentina
- Hospital Fernández (AR)
- Sanatorio Lopez Lima, Gral. Roca, Río Negro, Argentina
- Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (AR)
- Hospital Churruca, Buenos Aires, Argentina
- Fundacion Allende (AR)
- Hospital Pirovano, Buenos Aires, Argentina
- Sanatorio Julio Mëndez; Buenos Aires, Argentina
- Sanatorio de la Trinidad-San Isidro, Provincia de Buenos Aires, Argentina
- Sanatorio de la Trinidad-Mitre, Buenos Aires, Argentina
- Clínica de Los Arcos, Buenos Aires, Argentina
- Hospital Italiano Garibaldi, Rosario, Argentina
- Sanatorio Franchin, Buenos Aires, Argentina; and
- Hospital Velez Sarsfield, Buenos Aires, Argentina
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-01
- Volume
- 182
- Issue
- 1
- Pages
- 41-48
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2090332825
- Semantic Scholar
- 1fca77d42c933e6b2f8beee1b97266d783c6bb17
- Cited by
- 230
- References
- 45
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 22 · 2019: 3 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 13 · 2013: 30 · 2012: 34
- FWCI
- 26.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- 2009 H1N1 influenza A, pandemic influenza, mechanical ventilation, acute respiratory failure, viral pneumonia, mortality risk factors, APACHE II score, acute respiratory distress syndrome, multiple organ failure, bacterial co-infection, shock, acute kidney injury, prone positioning, recruitment maneuvers, hypoxemia, Argentina
- MeSH terms
- Adult, Hypoxia, Argentina, Disease Outbreaks, Female, Humans, Influenza, Human, Male, Middle Aged, Pneumonia, Pneumococcal, Pregnancy, Respiration, Artificial, Respiratory Distress Syndrome, Cohort Studies, APACHE, Influenza A Virus, H1N1 Subtype
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