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Proinflammatory Activity in Bronchoalveolar Lavage Fluids From Patients With ARDS, a Prominent Role for Interleukin-1
Abstract
Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1) have been found to be elevated in bronchoalveolar lavage (BAL) fluid and in plasma from patients with acute respiratory distress syndrome (ARDS). In order to measure the balance of proinflammatory cytokines and their inhibitors, we quantified the upregulation of intercellular adhesion molecules (ICAM-1) induced by ARDS BAL fluids in human alveolar type II-like (A459) cells, and defined proinflammatory activity as the amount of ICAM-1 induced by the SAL fluids. Proinflammatory activity was detected in 77% of the SAL fluids sampled during the first week of ARDS, was found maximal during the 3 first days after onset of ARDS, and was significantly greater than in BAL specimens from at risk patients. Blocking experiments with specific inhibitors of TNF and IL-1 added to the BAL fluids indicated that the bioactivity measured was mainly due to IL-1. In contrast, proinflammatory activity of conditioned supernates from endotoxin-treated alveolar macrophages was mostly due to TNF. Using a bioassay that measures balance of cytokines with their inhibitors, our results indicate that the net proinflammatory activity in ARDS BAL fluids is attributable to IL-1 and not to TNF.
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“IL-1 is a key cytokine driving proinflammatory activity in bronchoalveolar lavage fluid of patients with lung injury (118).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [118]
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Attenuation of Acute Lung Inflammation and Injury by Whole Body Cooling in a Rat Heatstroke Model
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“In fact, it has been shown that the levels of IL-1β in the BAL fluids are elevated in patients with adult respiratory distress syndrome [30].”
BackgroundPDX regulates inflammatory cell infiltration via resident macrophage in LPS‐induced lung injury
Yang, Y., Zhang, H., Mei, H., Xu, H., Xiang, S., Yang, Q., Zheng, S., Smith, F. G., Jin, S., & Wang, Q. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15679 · Cited by 25
Tracheobronchial Markers of Lung Injury in Smoke Inhalation Victims
Kurzius‐Spencer, M., Foster, K. N., Littau, S. R., Richey, K. J., Clark, B. M., Sherrill, D. L., Goodman, R. B., Boitano, S. A., & Burgess, J. L. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181667991 · Cited by 25
“IL-1 increases recruitment of neutrophils and other inflammatory cells and stimulates the secretion of other proinflammatory cytokines.(22) The increase in IL-1 that we report occurs mostly very early (within 6.”
BackgroundIs the ventilator responsible for lung and systemic inflammation ?
Pugin, J. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1320-8 · Cited by 25
“The alveolar space has been shown to be the site of an intense inflammatory reaction in patients with acute lung injury [16, 17].”
BackgroundSelf-citationBiological therapies in the acute respiratory distress syndrome
Boyle, A. J., McNamee, J. J., & McAuley, D. F. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.905536 · Cited by 23
“It is elevated in BAL and plasma of ARDS patients [40], and increases alveolar-capillary permeability; therefore, contributing to the development of inflammatory alveolar oedema [41].”
BackgroundMitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
Grazioli, S., Dunn-Siegrist, I., Pauchard, L.-A., Blot, M., Charles, P., & Pugin, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225468 · Cited by 23
“IL-1ß has been shown to play a major role as a local pro-inflammatory mediator in the context of ARDS and VILI, and is secreted by alveolar macrophages and by alveolar epithelial cells [6, 7, 31, 50].”
BackgroundSelf-citationOkuda, R., Matsushima, H., Aoshiba, K., Oba, T., Kawabe, R., Honda, K., & Amano, M. (2015) · SpringerPlus · doi:10.1186/s40064-015-1455-z · Cited by 24
Kim, H., Hart, J., Knatz, N. L., Hall, M. W., & Wewers, M. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4948 · Cited by 23
Yang, H.-H., Chang, C., Juei-Tang, C., et al. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181cb43fd · Cited by 23
Agouridakis, P., Kyriakou, D. S., Alexandrakis, M. G., Perisinakis, K., Karkavitsas, N., & Bouros, D. E. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.01081.x · Cited by 22
Kim, T., Yoon, H. J., Lim, C. M., Kim, E., Kim, M. J., & Koh, Y. (2006) · Inflammation · doi:10.1007/s10753-006-9001-3 · Cited by 22
Acute Lung Injury and Acute Respiratory Distress Syndrome
Vish, M. G., & Shanley, T. P. (2008) · Springer eBooks · doi:10.1007/978-1-84800-925-7_5 · Cited by 22
van Heerden, P. V., Abutbul, A., Sviri, S., Zlotnick, E., Nama, A., Zimro, S., el-Amore, R., Shabat, Y., Reicher, B., Falah, B., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718191 · Cited by 22
Brégeon, F., Papazian, L., Delpierre, S., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31818f0e20 · Cited by 21
“As a marker of PIA, surface ICAM-1 up-regulation was measured by direct enzyme-linked immunosorbent assay as previously described (23, 24), quantified using a standard curve, and expressed as arbitrary units per milliliter.”
BackgroundMethodSelf-citationHashemian, S. M. R., Mortaz, E., Tabarsi, P., Jamaati, H., Maghsoomi, Z., Khosravi, A., Garssen, J., Masjedi, M. R., Velayati, A. A., Folkerts, G., et al. (2014) · Journal of Inflammation · doi:10.1186/1476-9255-11-21 · Cited by 21
“In addition to CXCL-8, pulmonary concentrations of IL-6, TNF-α and IL-1β were also increased either during the development of, or during the early phase of, ARDS [33-37].”
BackgroundAcute eosinophilic pneumonia associated with shock
Buddharaju, V. L., Saraceno, J. L., Rosen, J. M., et al. (1999) · Critical Care Medicine · doi:10.1097/00003246-199909000-00048 · Cited by 21
MicroRNA-181b stimulates inflammation via the nuclear factor-κB signaling pathway in vitro
Wang, Y.-Z., Mao, G., Lv, Y., et al. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2702 · Cited by 20
“Considering inflammation as a system disorder (50), it would be interesting to examine whether miR‑181b is also involved in the inflammation in vivo .”
Assessment of the expression of biomarkers of uremic inflammation in dogs with renal disease
Nentwig, A., Schweighauser, A., Maissen-Villiger, C. A., et al. (2016) · American Journal of Veterinary Research · doi:10.2460/ajvr.77.2.218 · Cited by 20
Exhaled nitric oxide as biomarker of acute lung injury: an unfulfilled promise?
Boshier, P. R., Hanna, G. B., & Marczin, N. (2013) · Journal of Breath Research · doi:10.1088/1752-7155/7/1/017118 · Cited by 20
Metadata
- Authors
- Pugin, J., Ricou, B., Steinberg, K. P., Suter, P. M., & Martin, T. R.
- Affiliations
- University Hospital of Geneva (CH)
- Venue
- American journal of respiratory and critical care medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-06-01
- Volume
- 153
- Issue
- 6
- Pages
- 1850-1856
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2015667478
- Cited by
- 323
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 10 · 2013: 16 · 2012: 18
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P50HL030542, HL-30542)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- acute respiratory distress syndrome, bronchoalveolar lavage fluid, interleukin-1, TNF-α, inflammatory cytokines, ICAM-1, alveolar macrophages, endotoxin, cytokine inhibitors, lung inflammation
- MeSH terms
- Adult, Aged, Bronchoalveolar Lavage Fluid, Humans, Inflammation, Interleukin-1, Lung Neoplasms, Middle Aged, Prospective Studies, Respiratory Distress Syndrome, Time Factors, Tumor Necrosis Factor-alpha, Case-Control Studies, Macrophages, Alveolar
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