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Proinflammatory Activity in Bronchoalveolar Lavage Fluids From Patients With ARDS, a Prominent Role for Interleukin-1
Abstract
Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1) have been found to be elevated in bronchoalveolar lavage (BAL) fluid and in plasma from patients with acute respiratory distress syndrome (ARDS). In order to measure the balance of proinflammatory cytokines and their inhibitors, we quantified the upregulation of intercellular adhesion molecules (ICAM-1) induced by ARDS BAL fluids in human alveolar type II-like (A459) cells, and defined proinflammatory activity as the amount of ICAM-1 induced by the SAL fluids. Proinflammatory activity was detected in 77% of the SAL fluids sampled during the first week of ARDS, was found maximal during the 3 first days after onset of ARDS, and was significantly greater than in BAL specimens from at risk patients. Blocking experiments with specific inhibitors of TNF and IL-1 added to the BAL fluids indicated that the bioactivity measured was mainly due to IL-1. In contrast, proinflammatory activity of conditioned supernates from endotoxin-treated alveolar macrophages was mostly due to TNF. Using a bioassay that measures balance of cytokines with their inhibitors, our results indicate that the net proinflammatory activity in ARDS BAL fluids is attributable to IL-1 and not to TNF.
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“IL-1 is a key cytokine driving proinflammatory activity in bronchoalveolar lavage fluid of patients with lung injury (118).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [118]
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Items 301–323 of 323
Takeyama, N., Tanaka, T., & Noguchi, H. (2006) · Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute Medicine · doi:10.3893/jjaam.17.199
Leukocytes in ARDS-A minor role in a big symphony orchestra?
Suter, P. M. (1998) · Critical Care Medicine · doi:10.1097/00003246-199807000-00005
Self-citationPulmonary-Respiratory Medicine
Tonn, H. (2001) · JAMA · doi:10.1001/jama.285.7.943-jbk0221-3-1
Direktor, Ä., & Hofbeck, M. (2009)
Síndrome de insuficiencia respiratoria aguda tardío. Una entidad emergente
Esper, R. C. (2000) · Medicina Crítica
Totura, A. L. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/vkmg-md36
Perspectives thérapeutiques dans le SDRA
Pugin, J. (2008) · Springer eBooks · doi:10.1007/978-2-287-77986-2_16
Self-citationMatthay, M. A., & Murray, J. F. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00062-2
The War Against SARS-CoV-2: The Immune Giant Collapsing Under Its Own Rampaging Cytokine Storm
Sofra, X. (2021) · Journal of Endocrinology and Metabolism Research · doi:10.37191/mapsci-2582-7960-2(1)-013
“IL-1b is one of the central cytokines driving the lungs’ proinflammatory processes [25].”
BackgroundMetabolic reprogramming and redox perturbations
Aboushousha, R. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20211208ra
Mahjoub, Y., Levrard, M., Deguines, J.-B., Robert, B., & Dupont, H. (2012) · EMC-Anesthésie réanimation/Encyclopédie médico-chirurgicale. Anesthésie, réanimation · doi:10.1016/s0246-0289(12)70030-0
Mahjoub, Y., Levrard, M., Deguines, J.-B., Robert, B., & Dupont, H. (2012) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(12)62046-5
Mahjoub, Y., Levrard, M., Deguines, J.-B., Robert, B., & Dupont, H. (2012) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(12)61885-4 · Cited by 1
Proteome signature for differential diagnosis of patients with bilateral lung infiltrates
Oh, Y., Kim, K., Kim, H. J., et al. (2024) · ERJ Open Research · doi:10.1183/23120541.00762-2024
“Many studies have presented potential biomarkers associated with diagnosis or prognosis using bronchoalveolar lavage fluid (BALF) or plasma in patients with bilateral lung infiltrates [2 – 4].”
Syndrome de détresse respiratoire aiguë
(2014) · Médecine Intensive Réanimation · doi:10.1016/b978-2-294-08855-1.50083-8
Nosaka, N., Borges, V., Martinon, D., et al. (2025) · eLife · doi:10.7554/elife.101990.1
Nosaka, N., Borges, V., Martinon, D., et al. (2025) · eLife · doi:10.7554/elife.101990.2
Restoration of Alveolar Epithelial Function as a Therapeutic Strategy for Acute Lung Injury
Herrero, R., Sanchez, C., & Lorente, J. A. (2013) · Springer eBooks · doi:10.1007/978-3-642-35109-9_40
“IL-1β increases protein permeability and inhibits fluid transport across the human distal lung epithelium in vitro [21].”
BackgroundGordon, S. (2012) · University of Brighton Repository (University of Brighton)
Alveolar Immune Profiling Identifies Distinct Subphenotypes of Acute Respiratory FailurePreprint
Morrell, E. D., Liu, T., Orlov, M., Boers, L. S., Sathe, N. A., Schmitz, C., Mitchem, M. A., Chaize, A., Gao, L. Y., Mabrey, F. L., et al. (2026) · medRxiv · doi:10.64898/2026.01.13.26344060
Choi, H. J., Kim, M. J., Paik, J. H., Kim, D. J., & Jung, S. K. (2026) · Food Science and Biotechnology · doi:10.1007/s10068-026-02140-w
“Therefore, they are potential preventive/therapeutic targets in ALI/ARDS.”
Influential
Metadata
- Authors
- Pugin, J., Ricou, B., Steinberg, K. P., Suter, P. M., & Martin, T. R.
- Affiliations
- University Hospital of Geneva (CH)
- Venue
- American journal of respiratory and critical care medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-06-01
- Volume
- 153
- Issue
- 6
- Pages
- 1850-1856
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2015667478
- Cited by
- 323
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 10 · 2013: 16 · 2012: 18
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P50HL030542, HL-30542)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- acute respiratory distress syndrome, bronchoalveolar lavage fluid, interleukin-1, TNF-α, inflammatory cytokines, ICAM-1, alveolar macrophages, endotoxin, cytokine inhibitors, lung inflammation
- MeSH terms
- Adult, Aged, Bronchoalveolar Lavage Fluid, Humans, Inflammation, Interleukin-1, Lung Neoplasms, Middle Aged, Prospective Studies, Respiratory Distress Syndrome, Time Factors, Tumor Necrosis Factor-alpha, Case-Control Studies, Macrophages, Alveolar
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