Cited by 323Respiratory Support and MechanismsInflammation biomarkers and pathwaysImmune Response and Inflammation

The DOI matches its Crossref record.

Proinflammatory Activity in Bronchoalveolar Lavage Fluids From Patients With ARDS, a Prominent Role for Interleukin-1

Pugin, J, Ricou, B, Steinberg, K P, Suter, P M, Martin, T R·1996·American journal of respiratory and critical care medicine

DOI 10.1164/ajrccm.153.6.8665045

Open this paper in CoChat — free account

Abstract

Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1) have been found to be elevated in bronchoalveolar lavage (BAL) fluid and in plasma from patients with acute respiratory distress syndrome (ARDS). In order to measure the balance of proinflammatory cytokines and their inhibitors, we quantified the upregulation of intercellular adhesion molecules (ICAM-1) induced by ARDS BAL fluids in human alveolar type II-like (A459) cells, and defined proinflammatory activity as the amount of ICAM-1 induced by the SAL fluids. Proinflammatory activity was detected in 77% of the SAL fluids sampled during the first week of ARDS, was found maximal during the 3 first days after onset of ARDS, and was significantly greater than in BAL specimens from at risk patients. Blocking experiments with specific inhibitors of TNF and IL-1 added to the BAL fluids indicated that the bioactivity measured was mainly due to IL-1. In contrast, proinflammatory activity of conditioned supernates from endotoxin-treated alveolar macrophages was mostly due to TNF. Using a bioassay that measures balance of cytokines with their inhibitors, our results indicate that the net proinflammatory activity in ARDS BAL fluids is attributable to IL-1 and not to TNF.

Integrity signals

Registry

Crossref · 10.1164/ajrccm.153.6.8665045

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 201–300 of 323

Polynitroxyl-albumin (PNA) plus tempol attenuate lung capillary leak elicited by prolonged intestinal ischemia and reperfusion
Zhang, S., Li, H., Ma, L., et al. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00295-1 · Cited by 20
Relationship Between HMGB1 and Tissue Protective Effects of HSP72 in a LPS-Induced Systemic Inflammation Model
Hasegawa, A., Iwasaka, H., Hagiwara, S., et al. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.10.015 · Cited by 19
Dear SIRS, the concept of “alarmins” makes a lot of sense!
Pugin, J. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0888-4 · Cited by 19
Self-citation
VENTILATOR-INDUCED INJURY AUGMENTS INTERLEUKIN-1β PRODUCTION AND NEUTROPHIL SEQUESTRATION IN LIPOPOLYSACCHARIDE-TREATED LUNGS
Lin, S., Lin, H.-C., Lee, K.-Y., et al. (2007) · Shock · doi:10.1097/shk.0b013e3180487fb5 · Cited by 19
“The IL-1", rather than TNF-!, has been found to be the proinflammatory bioactive substance in the BAL fluid of patients with ARDS (32).”
BackgroundInfluential
Injury Induces Localized Airway Increases in Pro-Inflammatory Cytokines in Humans and Mice
Jonker, M. A., Hermsen, J. L., Gómez, F. E., Sano, Y., & Kudsk, K. A. (2010) · Surgical Infections · doi:10.1089/sur.2010.040 · Cited by 18
“Several investigators showed that pro-inflammatory cytokine concentrations increase in BAL specimens and correlate with both the risk of adult respiratory dysfunction syndrome (ARDS) and its pathogenesis after trauma [14-17].”
Proteomic study of acute respiratory distress syndrome: current knowledge and implications for drug development
Levitt, J. E., & Rogers, A. J. (2016) · Expert Review of Proteomics · doi:10.1586/14789450.2016.1172481 · Cited by 19
Gene Therapy for Acute Respiratory Distress Syndrome
Liu, J., & Dean, D. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.786255 · Cited by 16
“High concentrations of cytokines, such as IL-1β, TNFα, IL-6, and IL-8, are detected in plasma and BAL fluids and are associated with poor clinical outcomes of ARDS, such as mortality rate (Pugin et al., 1996; Parsons et al., 2005; McClintock et al., 2008).”
Background
Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19
Moftah, M. B., & Eswayah, A. (2022) · Health Sciences Review · doi:10.1016/j.hsr.2021.100011 · Cited by 17
Anti-inflammatory and anti-oxidant properties of Ipomoea nil (Linn.) Roth significantly alleviates cigarette smoke (CS)-induced acute lung injury via possibly inhibiting the NF-κB pathway
Zeng, L., Fatima, M., Syed, S. K., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113267 · Cited by 17
New Viral Diseases and New Possible Remedies by Means of the Pharmacology of the Renin-Angiotensin System
Sansoe, G. G., & Aragno, M. (2023) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1155/2023/3362391 · Cited by 17
“A dramatic consequence of this “cytokine storm” is invariably acute lung injury (ALI), clinically characterized by ARDS with exponentially elevated systemic levels of tumour necrosis factorα (TNF-α) and interleukin-1 (IL-1), along with a systemic inflammatory response characterized by hypotension, organ hypoperfusion,…”
Background
Octanal-induced inflammatory responses in cells relevant for lung toxicity
Song, M.-K., Lee, H.-S., Choi, H.-S., et al. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113506722 · Cited by 17
“Several studies have described the important role of IL-1 in acute lung injury.(48,49) Furthermore, IL1 induces the production of other proinflammatory cytokines.”
Background
Urokinase plasminogen activator released by alveolar epithelial cells modulates alveolar epithelial repair in vitro
van Leer‐Buter, C., Stutz, M., Haeberli, A., & Geiser, T. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-03-0162 · Cited by 17
“IL-1β is released during early stages of acute lung diseases andwas shown to be biologically active in oedema fluid from patients with acute respiratory distress syndrome (24).”
Background
Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhage
Matsutani, T., Kang, S., Miyashita, M., Sasajima, K., Choudhry, M. A., Bland, K. I., & Chaudry, I. H. (2006) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2006.07.012 · Cited by 17
Acute lung injury and acute respiratory distress syndrome
Vasudevan, A., Lodha, R., & Kabra, S. K. (2004) · The Indian Journal of Pediatrics · doi:10.1007/bf02730667 · Cited by 17
Implications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine Design
Gantt, S. M., Yao, L., Kollmann, T. R., et al. (2013) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/pit017 · Cited by 16
“with the acute respiratory distress syndrome and has negative inotropic effects on cardiac contractility [81, 82].”
Background
Apoptosis signal-regulating kinase-1 promotes inflammasome priming in macrophages
Immanuel, C. N., Teng, B., Dong, B. E., Gordon, E. M., Kennedy, J. A., Luellen, C. L., Schwingshackl, A., Cormier, S. A., Fitzpatrick, E. A., & Waters, C. M. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00199.2018 · Cited by 18
“Both IL-1 and IL-6 are increased in BALF of patients at risk for or with established ARDS/ALI (1, 2, 17, 34, 35, 39, 41, 45).”
Background
Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell
Hirsch, J., Chalkley, R. J., Bentley, T., et al. (2014) · Critical Care · doi:10.1186/cc13795 · Cited by 16
“Pugin J, Ricou B, Steinberg KP, Suter PM, Martin TR: Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1.”
ResultInfluential
Generation of a Transgenic Mouse with Lung-specific Overexpression of the Human Interleukin-1 Receptor Antagonist Protein
Wilmott, R. W., Kitzmiller, J. A., Fiedler, M. A., et al. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.18.3.2983 · Cited by 16
Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways
Wang, S., Liu, J., Dong, J., Fan, Z., Wang, F., Wu, P., Li, X., Kou, R., & Chen, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.919898 · Cited by 19
“And until now, there is no specific and effective pharmacologic strategy for the treatment of ALI/ARDS, which highlights the urgent need to develop therapeutic strategies (Fan et al., 2018).”
BackgroundInfluential
The Pro-Inflammatory Cytokine Cascade
Cavaillon, J., & Adib‐Conquy, M. (2002) · Springer eBooks · doi:10.1007/978-3-642-57210-4_4 · Cited by 15
Neuronal Wiskott‐Aldrich syndrome protein regulates TGF‐β1‐mediated lung vascular permeability
Wagener, B. M., Hu, M., Zheng, A., Zhao, X., Che, P., Brandon, A. P., Anjum, N., Snapper, S. B., Creighton, J. R., Guan, J., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600102r · Cited by 15
“IL-1b is an important inflammatory mediator that contributes to development of pulmonary edema associated withALI (6, 11, 49).”
Background
High-altitude pulmonary edema can be prevented by heat shock protein 70–mediated hyperbaric oxygen preconditioning
Tsai, M., Lin, H., Lin, M.-T., et al. (2014) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000000408 · Cited by 15
“The levels of IL-1A in the BAL fluid are elevated in patients with adult respiratory distress syndrome.(31) Both TNF-> and IL-6 are believe to be an important mediator in the early cascade of endotoxin-induced lung inflammation.”
Background
Respiratory System and Artificial Ventilation
Lucangelo, U., Pelosi, P. P., Aliverti, A., & W. A., Z. (2008) · Springer eBooks · doi:10.1007/978-88-470-0765-9 · Cited by 15
Anti-inflammatory Role of Mesenchymal Stem Cells in an Acute Lung Injury Mouse Model
Huh, J. W., Kim, W. Y., Park, Y. Y., et al. (2018) · Acute and Critical Care · doi:10.4266/acc.2018.00619 · Cited by 15
“Sepsis-induced ALI is caused by the interaction of inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, derived from neutrophils, alveolar macrophages, and vascular endothelial cells activated by endotoxin [29].”
Background
Protection from acute lung injury by a peptide designed to inhibit the voltage-gated proton channel
Zhao, R., Lopez, B. J., Schwingshackl, A., & Goldstein, S. A. N. (2022) · iScience · doi:10.1016/j.isci.2022.105901 · Cited by 14
“Confirming the salutary effects of C6 are via Hv1, genetic deletion of the channel similarly protects mice from LPS-induced ALI.”
BackgroundInfluential
Dexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome
Geng, Y., Li, R., He, S., Yang, H.-H., Deng, Q., Shao, X., Wu, Y., Xu, W., & Ma, Q. (2018) · Shock · doi:10.1097/shk.0000000000001289 · Cited by 14
“Despite rapid cooling and aggressive organ support, approx- imately 75% of patients with severe HS developed multiple organ dysfunction syndromes, and the most common dysfunc- tion is acute respiratory distress syndrome (ARDS) (4, 24).”
Background
In vivoeffect of surfactant on inflammatory cytokines during endotoxin-induced lung injury in rodents
Mittal, N., & Sanyal, S. N. (2011) · Journal of Immunotoxicology · doi:10.3109/1547691x.2011.591294 · Cited by 14
“Each of these LPS-induced changes are likely to significantly contribute to development of lung injury in general— even potentially ARDS (Pugin et al., 1996; Germann and Hafner, 1998; Beck-Schimmer et al., 2005; Mirzapoiazova et al., 2007; Bastarache and Blackwell, 2009; Lin et al., 2010; Warren et al., 2010)); these…”
Background
Pulmonary Edema and Acute Lung Injury
Matthay, M. A., & Martin, T. R. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4710-0.00055-9 · Cited by 13
Self-citation
SOCS-1 rescues IL-1β-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1
Galam, L., Soundararajan, R., Breitzig, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8543 · Cited by 13
“In ALI, along with elevation of inflammatory mediators [5] and aberrant surfactant production [6], there is a distinct influx of protein-rich edema fluid into the interstitial and alveolar spaces, leading to impaired alveolar fluid clearance”
Background
Current Knowledge of Acute Lung Injury and Acute Respiratory Distress Syndrome
Dechert, R. E., Haas, C. F., & Ostwani, W. (2012) · Critical Care Nursing Clinics of North America · doi:10.1016/j.ccell.2012.06.006 · Cited by 12
Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma
Jungraithmayr, W., FRINGS, C., Zissel, G., Prasse, A., Passlick, B., & Stoelben, E. (2008) · Respirology · doi:10.1111/j.1440-1843.2008.01391.x · Cited by 13
Comparison of the effect of aminophylline and low PEEP vs. high PEEP on EGF concentration in critically ill patients with ALI/ARDS
Salari, P., Mojtahedzadeh, M., Najafi, A., et al. (2005) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2004.00621.x · Cited by 13
Bronchoalveolar lavage fluids of patients with lung injury activate the transcription factor nuclear factor-κB in an alveolar cell line
Nys, M., Deby-Dupont, G. P., Habraken, Y., Legrand-Poels, S., Ledoux, D., Canivet, J.-L., Damas, P., & Lamy, M. (2002) · Clinical Science · doi:10.1042/cs1030577 · Cited by 13
23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways
Chen, C., Li, L., Liu, X., Zhang, D., Liu, Y., & Li, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115725 · Cited by 13
Death receptors mediate the adverse effects of febrile-range hyperthermia on the outcome of lipopolysaccharide-induced lung injury
Lipke, A. B., Matute‐Bello, G., Herrero, R., Wong, V. A., Mongovin, S. M., & Martin, T. R. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00314.2010 · Cited by 12
Self-citation
α1-Antitrypsin: Key Player or Bystander in Acute Respiratory Distress Syndrome?
Hogan, G., Geoghegan, P., Carroll, T. P., Clarke, J., McElvaney, O. F., McElvaney, O. J., McElvaney, N. G., & Curley, G. F. (2021) · Anesthesiology · doi:10.1097/aln.0000000000003727 · Cited by 11
Apios americana Medik Extract Alleviates Lung Inflammation in Influenza Virus H1N1- and Endotoxin-Induced Acute Lung Injury
Sohn, S., Lee, S., Cui, J., Jang, H. H., Kang, T., Kim, J.-K., Kim, I.-K., Lee, D., Choi, S., Yoon, I., et al. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1508.08017 · Cited by 12
Breath Biomarkers and the Acute Respiratory Distress Syndrome
Crader, K. M., & Repine, J. D. (2012) · Journal of Pulmonary & Respiratory Medicine · doi:10.4172/2161-105x.1000111 · Cited by 11
“For example, cytokines are increased in the lung [107,108], glutathione levels are decreased in the blood [35], uncomplexed ferrous iron could facilitate the formation of the highly-toxic hydroxyl radical [43,109], lactate might reflect the altered metabolic state or an increased exercise of breathing [43,109] of ARDS…”
Background
Acute respiratory distress syndrome epidemiology and pathophysiology
Morrison, R. J., & Bidani, A. (2002) · Chest Surgery Clinics of North America · doi:10.1016/s1052-3359(02)00004-2 · Cited by 11
Respuesta inflamatoria y apoptosis en la lesión pulmonar aguda
Pedreira, P. R., García-Prieto, E., Albaiceta, G. M., & Taboada, F. (2006) · Medicina Intensiva · doi:10.1016/s0210-5691(06)74523-5 · Cited by 11
IRF1 Mediates Growth Arrest and the Induction of a Secretory Phenotype in Alveolar Epithelial Cells in Response to Inflammatory Cytokines IFNγ/TNFα
Luciani, G. R., Barilli, A., Visigalli, R., Sala, R., Dall’Asta, V., & Rotoli, B. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063463 · Cited by 12
“It is one of the cytokines most commonly found in pulmonary edema and bronchoalveolar lavage fluids in ARDS [10,11].”
Background
Nebulization of Cyclic Arginine-Glycine-(D)-Aspartic Acid-Peptide Grafted and Drug Encapsulated Liposomes for Inhibition of Acute Lung Injury
Desu, H. R., Thoma, L. A., & Wood, G. C. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2366-9 · Cited by 11
“epithelial and endothelial cells) which release inflammatory chemokines and cytokines [2, 3].”
Perspectives on the use and risk of adverse events associated with cytokine-storm targeting antibodies and challenges associated with development of novel monoclonal antibodies for the treatment of COVID-19 clinical cases
Johnson, A. M., Barigye, R., & Saminathan, H. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2021.1908060 · Cited by 9
Human Identical Sequences, hyaluronan, and hymecromone ─ the new mechanism and management of COVID-19
Yang, S., Tong, Y., Chen, L., & Yu, W. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00077-0 · Cited by 10
Plasma cytokines: what we are measuring
Delarche, C., & Chollet‐Martin, S. (1999) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-199911000-00007 · Cited by 10
Effect of Chlorhexidine gluconate oral rinse on preventing of late onset ventilator associated pneumonia and it’s interaction with severity of illness
Ranjbar, H., Jafari, S., Kamrani, F. A., et al. (2010) · Journal of Critical Care Nursing · Cited by 9
Inflammasome in the Pathogenesis of Pulmonary Diseases
Xu, F., Wen, Z., Shi, X., & Fan, J. (2018) · Experientia supplementum · doi:10.1007/978-3-319-89390-7_6 · Cited by 9
“IL-1 Signaling IL-1 beta has been found in BALF from patients with ARDS (Pugin et al. 1996).”
BackgroundInfluential
Interleukin-1 Receptor Antagonist Gene (IL1RN) Variants Modulate the Cytokine Release Syndrome and Mortality of COVID-19
Attur, M. G., Petrilli, C. M., Adhikari, S., Iturrate, E., Li, X., Tuminello, S., Hu, N., Chakravarti, A., Beck, D. B., & Abramson, S. B. (2024) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiae031 · Cited by 13
Heat Stress Protects Against Lung Injury in the Neutropenic, Endotoxemic Rat
Heidemann, S. M., & Glibetić, M. (2005) · Inflammation · doi:10.1007/s10753-006-8969-4 · Cited by 8
Regional pulmonary inflammation in an endotoxemic ovine acute lung injury model
Fernandez-Bustamante, A., Easley, R. B., Fuld, M. K., et al. (2012) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.06.015 · Cited by 8
Mechanical ventilation and Streptococcus pneumoniae pneumonia alter mitochondrial homeostasis
Blot, M., Pauchard, L.-A., Dunn-Siegrist, I., Donze, J., Malnuit, S., Rebaud, C., Croisier, D., Piroth, L., Pugin, J., & Charles, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-30226-x · Cited by 8
Self-citation
Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)
Ostwani, W., & Shanley, T. P. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6356-5_7 · Cited by 8
Bear Bile Powder Ameliorates LPS-Induced Acute Lung Injury by Inhibiting CD14 Pathway and Improving Intestinal Flora: Exploration of “Fei (Lung)-Dachang (Large Intestine) Interaction” Theory
Cheng, L., Tian, H.-L., Lei, H.-Y., Wang, Y.-Z., Jiao, M.-J., Liang, Y.-H., Wu, Z.-Z., DENG, X., & Ren, Y. (2024) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-024-3556-4 · Cited by 8
A synthetic chalcone derivative, compound 39, alleviates lipopolysaccharide-induced acute lung injury in mice
Lin, Y.-T., Lu, Q., Chen, C., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173730 · Cited by 7
Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections
Vlahopoulos, S., Wang, K., Xue, Y., Zheng, X., Boldogh, I. R., & Pan, L. (2021) · Cells · doi:10.3390/cells10113067 · Cited by 9
“IL-1β also enhances fluid transport across the human distal lung epithelium in vitro [29].”
Background
Cytokines and Lung Injury
Suter, P. M., & Ricou, B. (1998) · Update in intensive care and emergency medicine · doi:10.1007/978-3-642-60733-2_3 · Cited by 7
Self-citation
Activation of the Heat Shock Response Attenuates the Interleukin 1β–Mediated Inhibition of the Amiloride-Sensitive Alveolar Epithelial Ion Transport
Howard, M., Roux, J., Iles, K. E., et al. (2013) · Shock · doi:10.1097/shk.0b013e31827e8ea3 · Cited by 6
The effects of an oral care practice on incidence of pneumonia among ventilator patients in ICUs of selected hospitals in Isfahan, 2010.
Khalifehzadeh, A., Parizade, A., Hosseini, A. M., & Yousefi, H. (2012) · Europe PMC (PubMed Central) · Cited by 6
Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome
Xu, W., Xia, S., Huo, W., et al. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200710020-00022 · Cited by 6
Hemofiltration and Immune Response in Severe Sepsis
Hörner, C., Schuster, S., Plachky, J., Hofer, S., Martin, E., & Weigand, M. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.09.019 · Cited by 6
“Often the production of proinflammatory cytokines is followed by secretion of inhibitors, such as soluble receptors or receptor antagonists [10].”
Background
Can mesenchymal stem cells be used to treat COVID‑19‑induced pneumonia? (Review)
Çeti̇n, İ., & Topçul, M. (2020) · Biomedical Reports · doi:10.3892/br.2020.1369 · Cited by 5
THE EFFECTS OF HEMODILUTION ON ACUTE INFLAMMATORY RESPONSES IN A BLEOMYCIN-INDUCED LUNG INJURY MODEL
Cheong, S. H., Lee, J. H., Lee, K. M., Cho, K. R., Yang, Y. I., Seo, J. Y., Yoon, S. Y., Lee, J. N., Choi, M. Y., Lee, S. E., et al. (2009) · Experimental Lung Research · doi:10.3109/01902140902946962 · Cited by 5
“In the early phase of ARDS, many inflammatory mediators, including endotoxin-binding proteins, TNF-α, IL-1β, IL6, chemokines, adhesive molecules, and matrix metalloproteinases, are increased in the BALF [24, 32, 33].”
Background
Cytokine-Networks and ARDS
Jorens, P. G., & Bossaert, L. L. (1997) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-662-13450-4_8 · Cited by 5
Correction: HMGB1 Accelerates Alveolar Epithelial Repair via an IL-1β- and αvβ6 Integrin-dependent Activation of TGF-β1
Pittet, J., Koh, H., Fang, X., Iles, K. E., Christiaans, S. C., Anjun, N., Wagener, B. M., Park, D. W., Zmijewski, J. W., Matthay, M. A., et al. (2013) · PLoS ONE · doi:10.1371/annotation/88f820f2-18dd-4d3b-8989-68f170b26b04 · Cited by 5
Cichorium intybus L. significantly alleviates cigarette smoke-induced acute lung injury by lowering NF-κB pathway activation and inflammatory mediators
Hussain, N., Ikram, N., Khan, K. U. R., Hussain, L., Alqahtani, A. M., Alqahtani, T., Hussain, M., Suliman, M., Alshahrani, M., & Sitohy, B. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22055 · Cited by 4
“In CS-induced ALI/ARDS models, pro-inflammatory factors (IL-6, IL-1 β , and KC) are increased in lungs due to oxidative stress [62, 84].”
Background
Injury and Repair
Zemans, R. L., & Downey, G. P. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00015-4 · Cited by 4
Higher plasma levels of Chemokine CCL19 are associated with poor SARS-CoV-2 acute respiratory distress syndrome (ARDS) outcomesPreprint
Balnis, J. (2020) · medRxiv · doi:10.1101/2020.05.21.20051300v2 · Cited by 4
Lavandula stoechas significantly alleviates cigarette smoke-induced acute lung injury via modulation of oxidative stress and the NF-κB pathway
Al-Joufi, F., Shaukat, S., Hussain, L., Khan, K. U. R., Hussain, N., Haddad, A. H. I. A., Alqahtani, A. M., Alqahtani, T., Momenah, M. A., Ibrahim, S., et al. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103834 · Cited by 3
Negative Pressure Therapy with Intraperitoneal Saline Instillation in the Open Septic Abdomen
Jiménez-Fuertes, M., Ruíz-Tóvar, J., Durán, M., et al. (2016) · International Journal of Surgery and Research · doi:10.19070/2379-156x-si03001 · Cited by 3
“edema and ascites formation, making the damaged intestine an area of inflammation sworn to ARDS and damage to other organs distance [6, 7].”
Background
IL-38 in Behçet's disease: Gene expression in bronchoalveolar lavage from patients having pulmonary involvement
Hamzaoui, K., Louhaichi, S., Salhi, M., et al. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106840 · Cited by 3
Changes in stroke presentation in neo-Covid patients: A case study
Kohli, A., Gupta, C., Dutta, S., & Madaan, C. (2020) · Interdisciplinary Neurosurgery · doi:10.1016/j.inat.2020.100949 · Cited by 3
Micronutrient zinc roles in adjunctive therapy for COVID-19 by enhancing patients immunoregulation and tolerance to the pathogen
Hoang, B. X., & Han, B. (2021) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000263 · Cited by 3
Lung oedema in acute lung injury
Nunes, S. L. (2007) · Springer eBooks · doi:10.1007/88-470-0351-2_31 · Cited by 3
“Concentrationsof IL-1b showing significant alveolar epithelial repair in vitro are in a similar range to the concentrations of IL-1b found in a pulmonary oedema fluid from patients with ALI and ARDS, indicating that IL-1bmay contribute to repair of the alveolar epithelium in early ALI and ARDS [65].”
Result
Acute effects of smoke exposure on the cellular and cytokine profile in isolated perfused lungs
Kyi, M., Miyazaki, Y., Inoue, T., et al. (2000) · Respiration Physiology · doi:10.1016/s0034-5687(00)00147-x · Cited by 3
Induction of Interleukin‐8 Release by Lung Epithelium with Cystic Fibrosis Epithelial Lining Fluid Is Marginally Affected by Inhibitors of Interleukin‐1β
Coulter, K. R., Allen, E. D., Hart, J., et al. (2000) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.20.1.64.34655 · Cited by 2
“measured by ELISA and functional cytokine activity in a similar bioassay.(14) Taken together, it is clear that future studies should involve a comprehensive analysis of relevant biologic factors and incorporate several assays to determine the biologic profile of the CF airway.”
Method
Interleukin-1β Participates in the Development of Pneumococcal Acute Lung Injury and Death by Promoting Alveolar Microvascular Leakage
Bong, Y., Shin, S. G., Koh, S. H., et al. (2015) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2015.45.2.93 · Cited by 2
Acute Lung Injury
Beasley, M. B. (2008) · Springer eBooks · doi:10.1007/978-0-387-68792-6_4 · Cited by 2
Mechanisms of Acute Lung Injury and Repair
Doerschug, K. C., & Hunninghake, G. W. (2008) · Elsevier eBooks · doi:10.1016/b978-032304048-8.50010-4 · Cited by 2
Lung Diseases
Ruwanpura, S. M., Rosli, S., & Tate, M. D. (2018) · Experientia supplementum · doi:10.1007/978-3-319-89390-7_4 · Cited by 2
Acute Respiratory Distress Syndrome (ARDS) in Neutropenic Patients
Mokart, D., Textoris, J., Ettori, F., et al. (2010) · Springer eBooks · doi:10.1007/978-3-642-15742-4_36 · Cited by 2
Effect of intravenous administration of the proinflammatory cytokine IL-1β on the chemoreceptor control of respiration
Danilova, G. A., Александров, В. Г., & Aleksandrova, N. P. (2023) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2023.01.63-70 · Cited by 2
Akut Solunum Sikintisi Sendromu
Yurdakul, A. S., Ünsal, E., & Yılmaz, L. (2002) · Cited by 2
Pulmonary Edema and the Adult Respiratory Distress Syndrome
Siegel, M., & Tocino, I. (1999) · Springer eBooks · doi:10.1007/978-1-4471-3440-4_12 · Cited by 1
Comparison of the systemic and pulmonary inflammatory response to endotoxin of neutropenic and non-neutropenic rats
Heidemann, S. M., & Glibetić, M. (2007) · Journal of Inflammation · doi:10.1186/1476-9255-4-7 · Cited by 2
“However, the influence of neutrophils on the production of TNF-α is controversial [6,28-32].”
Mediators of Acute Lung Injury: A Review
Sethi, J. M., & Waxman, A. B. (2001) · Clinical Pulmonary Medicine · doi:10.1097/00045413-200107000-00003 · Cited by 2
“This brings into question whether the predominant effect of this cytokine, at least in BAL fluids, is proinflammatory (5).”
Background
Transcriptomic profiling of disease severity in patients with COVID-19 reveals role of blood clotting and vasculature related genesPreprint
Masood, K. I., Mahmood, S. F., Shahid, S., Nasir, N., Ghanchi, N. K., Nasir, A., Jamil, B., Khanum, I., Razzak, S. A., Kanji, A., et al. (2020) · medRxiv · doi:10.1101/2020.06.18.20132571 · Cited by 2
“P3, had severe COVID-19; a (> 65 y) male who was critically ill on admission with Acute Respiratory Distress Syndrome (ARDS), septic shock, acute kidney injury and early disseminated intravascular coagulation (DIC) and required mechanical ventilation.”
BackgroundInfluential
Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formationPreprint
Nosaka, N., Borges, V., Martinon, D., et al. (2025) · eLife · doi:10.7554/elife.101990 · Cited by 2
“IL-1β plays a role in the inflammation observed in the lungs of ARDS patients, and the IL-1β level correlates with the severity of disease in these patients(Meduri, et al. 1995; Pugin et al. 1996).”
T HE A CUTE R ESPIRATORY D ISTRESS S YNDROME
Orraine, L., Are, B. W., & Atthay, A. M. (2000) · Cited by 1
Morphological and molecular markers in idiopathic pulmonary fibrosis
Calabrese, F., Giacometti, C., Lunardi, F., & Valente, M. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.4.505 · Cited by 1
Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation
Nosaka, N., Borges, V., Martinon, D., et al. (2025) · eLife · doi:10.7554/elife.101990.3 · Cited by 1
Acquired cystic fibrosis transmembrane conductance regulator dysfunction
Eisenhut, M., & Wallace, H. L. (2025) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-025-03127-y · Cited by 1
“The group concluded that the net pro-inflammatory activity in ARDS BAL fluids was attributable to IL-1 and not to TNF [71].”
Pathophysiology of ARDS
Chiumello, D., Barbas, C. S. V., & Pelosi, P. P. (2008) · Springer eBooks · doi:10.1007/978-88-470-0765-9_7 · Cited by 1
“Furthermore, the prevalence of pro-inflammatory activity was due more to IL-1β than to TNF-α [35].”
Background
Chronologie et ⪡compartimentalisation⪢ de la réponse inflammatoire au cours du choc septique et du syndrome de détresse respiratoire de l'adulte
Pugin, J. (2000) · Réanimation Urgences · doi:10.1016/s1164-6756(00)90036-7 · Cited by 1
Self-citation
Adult respiratory distress syndrome (ARDS) after chemotherapy
van de Wetering, M. D., & Peper, J. A. K. (2000) · Medical and Pediatric Oncology · doi:10.1002/(sici)1096-911x(200006)34:6 · Cited by 1
Perfil temporal da inflamação pulmonar induzida pela isquemia/reperfusão intestinal em ratos. Estudo do papel do sistema linfático.
Vitoretti, L. B. (2010) · doi:10.11606/d.42.2010.tde-06082010-133158 · Cited by 1
DIAGNOSTIC ASPECTS OF EXHALED NITRIC OXIDE IN CARDIOTHORACIC ANAESTHESIA
SZABÓ, A., Kövesi, T., GÁL, J., Royston, D., & Marczin, N. (2005) · doi:10.1142/9789812701954_0014 · Cited by 1
Cytokines and Acute Respiratory Infections
Feldman, C. H. (1998) · Sepsis · doi:10.1023/a:1009733224900 · Cited by 1
Biotrauma: Signal Transduction and Gene Expression in the Lung
dos Santos, C. C., Liu, M., & Slutsky, A. S. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1427-5_19
Biologic Markers of Acute Lung Injury
Matthay, M. A., Conner, E. R., Ware, L. B., et al. (1998) · Springer eBooks · doi:10.1007/978-1-4419-8634-4_25
Role of endogenous histamine on the pathogenesis of endotoxin-induced acute lung injury
Koh, Y., Kim, T.-H., Yoon, H. J., Lim, C. M., Kim, E., & Kim, M. J. (2003)

Authors: Pugin, J., Ricou, B., Steinberg, K. P., Suter, P. M., & Martin, T. R.
Affiliations: University Hospital of Geneva (CH)
ORCID: Pugin, J
Ricou, B
Martin, T R
Venue: American journal of respiratory and critical care medicine
Publisher: Oxford University Press (OUP)
Published: 1996-06-01
Volume: 153
Issue: 6
Pages: 1850-1856
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/ajrccm.153.6.8665045
OpenAlex: W2015667478
Cited by: 323
References: 0
Citations by year: 2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 10 · 2013: 16 · 2012: 18
FWCI: 15.35
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (P50HL030542, HL-30542)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: acute respiratory distress syndrome, bronchoalveolar lavage fluid, interleukin-1, TNF-α, inflammatory cytokines, ICAM-1, alveolar macrophages, endotoxin, cytokine inhibitors, lung inflammation
MeSH terms: Adult, Aged, Bronchoalveolar Lavage Fluid, Humans, Inflammation, Interleukin-1, Lung Neoplasms, Middle Aged, Prospective Studies, Respiratory Distress Syndrome, Time Factors, Tumor Necrosis Factor-alpha, Case-Control Studies, Macrophages, Alveolar

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Proinflammatory Activity in Bronchoalveolar Lavage Fluids From Patients With ARDS, a Prominent Role for Interleukin-1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks