The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide.
Abstract
Exhaled nitric oxide (NO) may aid in monitoring pulmonary disease. The single-breath NO profile (subjects with nose clip) was described as a NO peak followed by a plateau (NO(PLAT)). Published exhaled NO values vary greatly, possibly due to contamination with nasal NO and differing respiratory maneuvers. We developed a technique to measure pulmonary NO, without nasal NO, by having the subject maintain a positive expiratory pressure (ensuring vellum closure), and we examined the variation in NO(PLAT) over a range of expiratory flows (4.2 to 1,550 ml/s). NO(PLAT) values rose almost 35-fold (3.2 +/- 1.4 ppb to 110.5 +/- 54.8 ppb) with decreasing flow, described by NO(PLAT) = 208.6795 x (flow rate)(-0.5995). However, NO excretion showed an almost 11-fold rise as flow increased. In summary, we present a simple technique for measuring exhaled NO without contamination by nasal NO. There is a marked flow dependence of exhaled NO concentration and excretion. Exhaled pulmonary NO is best measured at very low flow rates to amplify the signal and must be related to the expiratory flow employed.
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Cites
Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P., & Moncada, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91268-h · Cited by 964
The biology of nitrogen oxides in the airways
Gaston, B., Drazen, J. M., Loscalzo, J., & Stamler, J. S. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.7508323 · Cited by 918
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(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-710st · Cited by 3,203
Nitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903
Endogenous Airway Acidification: Implications for Asthma Pathophysiology
HUNT, J. F., FANG, K., MALIK, R., SNYDER, A., MALHOTRA, N., PLATTS-MILLS, T. A. E., & GASTON, B. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.3.9911005 · Cited by 649
Exhaled nitric oxide from lung periphery is increased in COPD
Brindicci, C., Ito, K., Resta, O., Pride, N. B., Barnes, P. J., & Kharitonov, S. A. (2005) · European Respiratory Journal · doi:10.1183/09031936.04.00125304 · Cited by 206
Objective monitoring of nasal airway inflammation in rhinitis
Howarth, P. H., Persson, C. G. A., Meltzer, E. O., Jacobson, M. R., Durham, S. R., & Silkoff, P. E. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.12.1134 · Cited by 139
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Metadata
- Authors
- Silkoff, P. E., McClean, P. A., Slutsky, A. S., Furlott, H. G., Hoffstein, E., Wakita, S., Chapman, K. R., Szalai, J. P., & Zamel, N.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-01
- Volume
- 155
- Issue
- 1
- Pages
- 260-267
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1996634690
- Cited by
- 468
- References
- 2
- FWCI
- 45.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Silkoff, P. E., McClean, P. A., Slutsky, A. S., Furlott, H. G., Hoffstein, E., Wakita, S., Chapman, K. R., Szalai, J. P., & Zamel, N. (1997). Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.155.1.9001322
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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