The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Endogenous Airway Acidification: Implications for Asthma Pathophysiology
Abstract
Airway concentrations of many reactive nitrogen and oxygen species are high in asthma. The stability and bioactivities of these species are pH-dependent; however, the pH of the airway during acute asthma has not previously been studied. As with gastric and urinary acidification, asthmatic airway acidification could be expected dramatically to alter the concentrations and bioactivities/cytotoxicities of endogenous nitrogen oxides. Here, we demonstrate that the pH of deaerated exhaled airway vapor condensate is over two log orders lower in patients with acute asthma (5.23 +/- 0.21, n = 22) than in control subjects (7.65 +/- 0.20, n = 19, p < 0. 001) and normalizes with corticosteroid therapy. Values are highly reproducible, unaffected by salivary or therapeutic artifact, and identical to samples taken directly from the lower airway. Further, at these low pH values, the endogenous airway compound, nitrite, is converted to nitric oxide (NO) in quantities sufficient largely to account for the concentrations of NO in asthmatic expired air, and eosinophils undergo accelerated necrosis. We speculate that airway pH may be an important determinant of expired NO concentration and airway inflammation, and suggest that regulation of airway pH has a previously unsuspected role in asthma pathophysiology.
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Cites
Eosinophilic Inflammation in Asthma
Bousquet, J., Chanez, P., Lacoste, J. Y., Barnéon, G., Ghavanian, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., Godard, P., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010113231505 · Cited by 2,499
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338
Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution
Rennard, S. I., Basset, G., Lecossier, D., O'Donnell, K. M., Pinkston, P., Martin, P. G., & Crystal, R. G. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.2.532 · Cited by 1,131
Fas-Induced Caspase Denitrosylation
Mannick, J. B., Hausladen, A., Liu, L., Hess, D. T., Zeng, M., Miao, Q. X., Kane, L. S., Gow, A. J., & Stamler, J. S. (1999) · Science · doi:10.1126/science.284.5414.651 · Cited by 742
Gong, J. P., Traganos, F., & Darzynkiewicz, Z. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1184 · Cited by 656
Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.
Gaston, B., Reilly, J., Drazen, J. M., Fackler, J., Ramdev, P., Arnelle, D., Mullins, M. E., Sugarbaker, D. J., Chee, C., Singel, D. J., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10957 · Cited by 623
Self-citationInhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.
Kharitonov, S. A., Yates, D. H., & Barnes, P. J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.1.8542158 · Cited by 580
Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide.
Silkoff, P. E., McClean, P. A., Slutsky, A. S., Furlott, H. G., Hoffstein, E., Wakita, S., Chapman, K. R., Szalai, J. P., & Zamel, N. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001322 · Cited by 468
OXIDANT ACTIVITY IN EXPIRED BREATH OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME
Baldwin, S., Grum, C., Boxer, L., Simon, R., Ketai, L., & Devall, L. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91895-7 · Cited by 331
Protons: small stimulants of capsaicin-sensitive sensory nerves
Bevan, S., & Geppetti, P. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90149-x · Cited by 298
Cited by
Exhaled breath condensate: methodological recommendations and unresolved questions
Horváth, I., Hunt, J., & Barnes, P. J. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00029705 · Cited by 1,284
Self-citationRespiratory effects of exposure to diesel traffic in persons with asthma
McCreanor, J., Cullinan, P., Nieuwenhuijsen, M. J., Stewart-Evans, J., Malliarou, E., Jarup, L., Harrington, R., Svartengren, M., Han, I.-K., Ohman-Strickland, P., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071535 · Cited by 898
Nitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903
Self-citationGladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441
Role of CFTR in epithelial physiology
Saint-Criq, V., & Gray, M. A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2391-y · Cited by 433
Metadata
- Authors
- HUNT, J. F., FANG, K., MALIK, R., SNYDER, A., MALHOTRA, N., PLATTS-MILLS, T. A. E., & GASTON, B.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 161
- Issue
- 3
- Pages
- 694-699
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1899229346
- Cited by
- 649
- References
- 32
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- HUNT, J. F., FANG, K., MALIK, R., SNYDER, A., MALHOTRA, N., PLATTS-MILLS, T. A. E., & GASTON, B. (2000). Endogenous Airway Acidification: Implications for Asthma Pathophysiology. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.161.3.9911005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
