The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Risk Factors for Near-fatal Asthma: A Case–Control Study in Hospitalized Patients with Asthma
Abstract
We prospectively recruited patients admitted to the hospital with severe asthma to comprehensively evaluate the association of historical and physiologic features with the risk of near-fatal asthma (NFA). A case-control study design was used. All patients admitted with NFA (cases) were identified prospectively and compared with asthma patients admitted during the same period without respiratory failure (controls). Nineteen cases (age: 40.2 +/- 12.0 yr) (mean +/- SD) and 80 controls (age: 36 +/- 13.5 yr) were enrolled. Duration of asthma, gender, smoking status, ethnicity, and prevalence of atopy were similar in the case and control groups. More than 80% of patients in both groups reported worsening symptoms for more than 48 h before admission, and more than 50% were worse for longer than 7 d. There was no difference in degree of airways obstruction or bronchial hyperresponsiveness (PC20). Perception of dyspnea was similar in the cases and controls, but among cases the males had greater impairment than the females (Borg score: 1.9 +/- 1. 4 versus 3.9 +/- 1.2: p = 0.05). Univariate analysis identified a history of previous mechanical ventilation (OR: 27.5; 95% CI: 6.60 to 113.7), admission to the intensive care unit (ICU) (OR: 9.9; 95% CI: 3.0 to 32.9), history of worse asthma during January and February (OR: 3.5; 95% CI: 1.0 to 11.8), and use of air-conditioning (OR: 15.0; 95% CI: 1.3 to 166) as risk factors for NFA. Of concern was the dependence of most patients (59.8%) on the emergency department (ED) for initial care, and the small number of cases (16%) in which patients visited a physician before admission to the hospital. We have confirmed risk factors identified previously in retrospective studies of fatal and NFA, and have also shown that hospitalized patients with asthma, irrespective of severity of their asthma, share several characteristics, especially in terms of their failure to respond to worsening asthma.
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Cites
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Cited by
Global strategy for asthma management and prevention: GINA executive summary
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Acute exacerbations of asthma: epidemiology, biology and the exacerbation‐prone phenotype
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Metadata
- Authors
- TURNER, M. O., NOERTJOJO, K., VEDAL, S., BAI, T., CRUMP, S., & MARK FITZGERALD, J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-06-01
- Volume
- 157
- Issue
- 6
- Pages
- 1804-1809
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1903161601
- Cited by
- 275
- References
- 25
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- TURNER, M. O., NOERTJOJO, K., VEDAL, S., BAI, T., CRUMP, S., & MARK FITZGERALD, J. (1998). Risk Factors for Near-fatal Asthma: A Case–Control Study in Hospitalized Patients with Asthma. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.157.6.9708092
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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