Baroreflex Control of Heart Rate in a Canine Model of Obstructive Sleep Apnea
Abstract
We have recently demonstrated the development of systemic hypertension in a canine model of obstructive sleep apnea (OSA), but the underlying physiological mechanisms were not identified. Therefore, the purpose of this study was to examine the effect of OSA on arterial baroreceptor control of heart rate (HR) in this canine model. OSA was produced in three dogs for 1 to 3 mo. Baroreflex control of HR was determined with graded infusions of vasoactive agents (phenylephrine and nitroprusside) administered over 30 to 60 s, during which steady-state systolic blood pressure (BP) and cardiac R-R interval responses were recorded. BP was measured with a permanently implanted arterial catheter and a telemetry system. Although, as previously reported, OSA resulted in increases in daytime (awake) mean BP of 6.0 to 26.8 mm Hg, there was no change in daytime baseline HR or in the slope of the systolic BP–R-R interval curve (p > 0.2). The findings demonstrate that OSA in the dog is associated with resetting of the baroreceptors to a higher pressure, but no change in baroreflex sensitivity.
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Repeated episodes of hypoxia, either from obstructive sleep apnea or experimental induction, result in elevation of blood pressure and altered metabolic function.
“Repeated episodes of hypoxia, either occurring as a result of obstructive sleep apnea 35 or because of experimental induction, both result in elevation of blood pressure 36 and altered metabolic function.37”
From Rapid Onset of Renal Sympathetic Nerve Activation in Rabbits Fed a High-Fat Diet (2012) · cites this paper as [36]
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- Authors
- BROOKS, D., HORNER, R. L., FLORAS, J. S., KOZAR, L. F., RENDER-TEIXEIRA, C. L., & PHILLIPSON, E. A.
- Affiliations
- University of Toronto (CA)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-04-01
- Volume
- 159
- Issue
- 4
- Pages
- 1293-1297
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2072893598
- Cited by
- 58
- References
- 25
- Citations by year
- 2024: 1 · 2020: 1 · 2017: 2 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- obstructive sleep apnea, baroreflex sensitivity, rate control, baroreceptor resetting, systemic hypertension, canine model, phenylephrine, sodium nitroprusside, autonomic regulation
- MeSH terms
- Animals, Blood Pressure, Dogs, Female, Heart Rate, Male, Sleep Apnea Syndromes, Baroreflex
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