Changing approaches to the diagnosis of tuberculosis
Abstract
Since this subject was last reviewed in the American Journal of Respiratory and Critical Care Medicine (1), new diagnostic tests for tuberculosis have been approved for use in the United States, Europe, and other industrialized regions, and there has been significant clinical experience with their use. In addition, several other new diagnostic assays have been studied and may be nearing approval by the Food and Drug Administration (or similar agencies in other countries) for routine clinical use. This commentary will review the need for new diagnostic tests for tuberculosis, examine the status of currently available tests and of several promising tests in development, and discuss potential scenarios in which such diagnostic tests might be used.
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Histopathological exam traditionally exhibits granulomas with a central area of caseation surrounded by chronic inflammatory infiltrates and Langhans multinucleated giant cells.
“Histopathological exam traditionally exhibits granulomas with a central area of caseation surrounded by chronic inflammatory infiltrates and Langhans multinucleated giant cells [47].”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [47]
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Primary Laryngeal Tuberculosis: A Series of 15 Cases
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“Histopathological exam traditionally exhibits granulomas with a central area of caseation surrounded by chronic inflammatory infiltrates and Langhans multinucleated giant cells [47].”
- Authors
- SCHLUGER, N. W.
- Affiliations
- Columbia University (US)
- Corresponding author
- SCHLUGER, NEIL W.
- ORCID
- SCHLUGER, NEIL W.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-12-01
- Volume
- 164
- Issue
- 11
- Pages
- 2020-2024
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2124237713
- Cited by
- 60
- References
- 34
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 5
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K24HL004074)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Keywords
- tuberculosis diagnosis, FDA approval, tuberculosis serology, molecular diagnosis, Mycobacterium tuberculosis
- MeSH terms
- Bacteriological Techniques, Developing Countries, Drug Resistance, Health Resources, Humans, Microbial Sensitivity Tests, Sensitivity and Specificity, Serotyping, Skin Tests, Sputum, Tuberculin, Tuberculosis, United States, Reproducibility of Results, Developed Countries, Nucleic Acid Amplification Techniques
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