CoChat
Sign Up
Cited by 11Diagnosis and treatment of tuberculosisVoice and Speech DisordersTuberculosis Research and Epidemiology

Laryngeal tubercolosis: A case report with focus on voice assessment and review of the literature

Open access
Migliorelli, Andrea, Mazzocco, Tommaso, Bonsembiante, Anna, Bugada, Daniele, Fantini, Marco, Elli, Fabrizia, Stacchini, Marco·2022·Acta Otorhinolaryngologica Italica
DOI 10.14639/0392-100x-n2091PMC PMC9793137
Open this paper in CoChat — free accountOpen PDF

Abstract

Laryngeal tuberculosis (LTB) is a rare manifestation of tuberculosis (TB), accounting for 1% of all TB cases. Despite its rarity it is the most frequent laryngeal granulomatous disease. We performed a systematic literature review of the last 20 years on LTB and also present a case from our hospital with special focus on voice assessment. The literature review includes a total of 308 cases, involving studies from seven countries. In all, 64.3% of patients were males. At the time of diagnosis, the mean age range was 44.6-56.5 years. Odynophagia, hoarseness and dysphonia were the most frequent presenting symptoms. In 64 cases, the initial suspicion was laryngeal cancer. Most cases involved the true vocal folds. In about a third of cases a primary LTB with normal chest radiographic was found. Although it can be treated successfully, LTB may cause significant changes in voice quality. Nowadays, LTB is rarely diagnosed and may be confused with laryngeal cancer, it should also be included in the differential diagnosis with all other chronic benign inflammatory and non-inflammatory diseases of the larynx.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.14639/0392-100x-n2091

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Various studies found dysphonia as the most common symptom, followed by dyspnea and odynophagia.

    “Various studies found dysphonia as the most common symptom, followed by dyspnea and odynophagia [37,48].”

    From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [48]

    The Results (Literature review) give a different ranking: odynophagia or pharyngodynia was reported in 174 of 308 cases, compared with dysphonia in 125. They describe shortness of breath or dyspnoea (35 of 308) as an occasional presenting symptom, not the second most common. (LLM, conf=0.90)

    Checked by a reasoning model — may be wrong.

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [9]Broek PV. Scott Brown’s otolaryngology. Sixth Edition. Oxford: Taylor Francis ltd 1997.
  2. [16]Kirtane MV de Souza CE. Otorhinolaryngology - Head and Neck Surgery series. First edition. India: Thieme; 2013.

Cited by

Sorted by citations

Related

Authors
Migliorelli, A., Mazzocco, T., Bonsembiante, A., Bugada, D., Fantini, M., Elli, F., & Stacchini, M.
Affiliations
  • University of Ferrara (IT)
  • Ospedale Koelliker (IT)
  • University of Insubria (IT)
  • Ospedale “M. Bufalini” di Cesena (IT)
Corresponding author
Migliorelli, Andrea
ORCID
Venue
Acta Otorhinolaryngologica Italica
Publisher
Pacini Editore
Published
2022-10
Volume
42
Issue
5
Pages
407-414
ISSN
  • 0392-100X (ISSN-L)
  • 1827-675X
DOI
10.14639/0392-100x-n2091
PMC
PMC9793137
OpenAlex
W4312093688
Cited by
11
References
31
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 5
FWCI
2.39
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Acta Otorhinolaryngologica Italica (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
  • Health Sciences › Medicine › Physiology › Voice and Speech Disorders
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Keywords
laryngeal tuberculosis, voice assessment, hoarseness, dysphonia, odynophagia, true vocal fold, laryngeal tuberculosis treatment
MeSH terms
Humans, Larynx, Dysphonia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review