The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Elevated Soluble ST2 Protein Levels in Sera of Patients with Asthma with an Acute Exacerbation
Abstract
Previous studies have reported that ST2 is preferentially expressed on Th2 cells and plays a critical part in controlling airway inflammation in murine models of asthma. However, the clinical role of ST2 in patients with bronchial asthma remains unclear. In our study, we examined 56 patients with atopic asthma in a nonattack phase and 200 nonatopic normal volunteers for healthy control, and analyzed the relationship of their serum ST2 levels to asthma severity, pulmonary function, and laboratory data. Of the 56 patients with atopic asthma, 30 exhibited asthmatic exacerbation, and their serum ST2 levels were also analyzed. The serum ST2 levels were low, but a statistical difference was found between patients with nonattack asthma and the healthy control group (p < 0.05). We also found a differential rise of serum ST2 level that correlates well with the severity of asthma exacerbation. Furthermore, the serum ST2 levels during asthma exacerbation statistically correlated with the percentage of predicted peak expiratory flow (r = -0.634, p = 0.004) and Pa(CO(2)) (r = 0.516, p = 0.003). These results suggest that soluble human ST2 protein in sera may be related to Th2-mediated allergic inflammation inducing acute exacerbation in patients with atopic asthma.
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Cites
Asthma and Wheezing in the First Six Years of Life
Martinez, F. D., Wright, A. L., Taussig, L. M., Holberg, C. J., Halonen, M., & Morgan, W. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320301 · Cited by 3,823
Cited by
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Measurement of the Interleukin Family Member ST2 in Patients With Acute Dyspnea
Januzzi, J. L., Peacock, W. F., Maisel, A. S., Chae, C. U., Jesse, R. L., Baggish, A. L., O’Donoghue, M., Sakhuja, R., Chen, A. A., van Kimmenade, R. R. J., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.05.014 · Cited by 522
IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex
Chackerian, A. A., Oldham, E. R., Murphy, E. E., Schmitz, J., Pflanz, S., & Kastelein, R. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2551 · Cited by 508
Metadata
- Authors
- OSHIKAWA, K., KUROIWA, K., TAGO, K., IWAHANA, H., YANAGISAWA, K., OHNO, S., TOMINAGA, S.-I., & SUGIYAMA, Y.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-07-15
- Volume
- 164
- Issue
- 2
- Pages
- 277-281
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2068044260
- Cited by
- 314
- References
- 1
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Elevated Soluble ST2 Protein Levels in Sera of Patients with Asthma with an Acute Exacerbation. https://app.cochat.ai/papers/10.1164/ajrccm.164.2.2008120
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- OSHIKAWA, K., KUROIWA, K., TAGO, K., IWAHANA, H., YANAGISAWA, K., OHNO, S., TOMINAGA, S.-I., & SUGIYAMA, Y. (2001). Elevated Soluble ST2 Protein Levels in Sera of Patients with Asthma with an Acute Exacerbation. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.164.2.2008120
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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