The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex
Abstract
IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune response. IL-33 mediates signal transduction through ST2, a receptor expressed on Th2 and mast cells. In this study, we demonstrate that IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex. Additionally, IL-1RAcP is required for IL-33-induced in vivo effects, and IL-33-mediated signal transduction can be inhibited by dominant-negative IL-1RAcP. The implications of this shared usage of IL-1RAcP by IL-1(α and β) and IL-33 are discussed.
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Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex
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Elevated Soluble ST2 Protein Levels in Sera of Patients with Asthma with an Acute Exacerbation
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Cited by
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179
IL‐1, IL‐18, and IL‐33 families of cytokines
Arend, W. P., Palmer, G., & Gabay, C. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00624.x · Cited by 912
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
Cayrol, C., & Girard, J.-P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812690106 · Cited by 707
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Lüthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G., Taylor, R. C., Kersse, K., Vandenabeele, P., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.007 · Cited by 677
Metadata
- Authors
- Chackerian, A. A., Oldham, E. R., Murphy, E. E., Schmitz, J., Pflanz, S., & Kastelein, R. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08
- Volume
- 179
- Issue
- 4
- Pages
- 2551-2555
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2166623795
- Cited by
- 508
- References
- 20
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chackerian, A. A., Oldham, E. R., Murphy, E. E., Schmitz, J., Pflanz, S., & Kastelein, R. A. (2007). IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex. The Journal of Immunology. https://doi.org/10.4049/jimmunol.179.4.2551
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