The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Prenatal Nicotine Exposure Alters Pulmonary Function in Newborn Rhesus Monkeys
Abstract
Epidemiological studies have shown that offspring of women who smoke during pregnancy have abnormal lung function and associated higher incidences of lower respiratory disorders. The recent identification of nicotinic acetylcholine receptors (nAChR) in fetal lung suggests that the direct interaction between nicotine and nAChR in fetal lung may underlie the postnatal pulmonary abnormalities seen in such infants. This hypothesis was tested in monkeys to determine if maternal nicotine exposure would produce changes in lung mechanics in newborn monkeys similar to those observed in human infants whose mothers smoked during pregnancy. Timed pregnant rhesus monkeys were infused with either nicotine (1.5 mg/kg/d, n = 7) or saline (n = 7) using subcutaneous osmotic pumps from Day 26 to 160 of gestation. On Day 160 of pregnancy (term = 165 d), fetuses were delivered by C-section, and the following day were subjected to pulmonary function testing. After testing, animals were sacrificed, and lungs weighed and fixed. Lung weight and fixed lung volume decreased (16% and 14%, respectively) significantly following in utero nicotine exposure. Peak tidal expiratory flow, FEV(0.2), mean mid-expiratory flow, forced expiratory volume at peak expiratory flow (FEV(PEF)), and FEV(PEF)/FVC% were significantly lower in newborns exposed to nicotine during gestation. Absolute and specific pulmonary resistance increased significantly whereas absolute and specific dynamic compliance remained unchanged in prenatally nicotine-treated pups. These changes in pulmonary function are strikingly similar to the changes observed in offspring of human smokers. This suggests that the interaction of nicotine with nAChR in developing lung is responsible for the altered pulmonary mechanics observed in human infants whose mothers smoked during pregnancy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In both monkeys and mice, exposure to prenatal nicotine alone, at levels similar to that of smokers, causes similar decreases in forced expiratory flow.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [207]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lung function. Assessment and application in medicine
(1969) · Tubercle · doi:10.1016/0041-3879(69)90013-0 · Cited by 853
The Effect of Maternal Smoking during Pregnancy on Early Infant Lung Function
Hanrahan, J. P., Tager, I. B., Segal, M. R., Tosteson, T. D., Castile, R. G., Vunakis, H. V., Weiss, S. T., & Speizer, F. E. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.5.1129 · Cited by 527
Stick, S., Burton, P., Gurrin, L., Sly, P., & Souëf, P. L. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04446-7 · Cited by 478
Luck, W., Nau, H., Hansen, R., & Steldinger, R. (2017) · Developmental Pharmacology and Therapeutics · doi:10.1159/000457063 · Cited by 444
Nicotinic acetylcholine receptors in health and disease
Lindstrom, J. (1997) · Molecular Neurobiology · doi:10.1007/bf02740634 · Cited by 443
Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function
Gilliland, F. D. (2000) · Thorax · doi:10.1136/thorax.55.4.271 · Cited by 359
THE EFFECTS OF MATERNAL SMOKING ON FETAL AND INFANT MORTALITY
Kleinman, J. C., Pierre, M. B., Madans, J. H., Land, G. H., & SCHRAMM, W. F. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114803 · Cited by 325
Lung Function, Pre- and Post-natal Smoke Exposure, and Wheezing in the First Year of Life
Tager, I. B., Hanrahan, J. P., Tosteson, T. D., Castile, R. G., Brown, R. W., Weiss, S. T., & Speizer, F. E. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.4.811 · Cited by 315
Sekhon, H. S., Jia, Y., Raab, R., Kuryatov, A., Pankow, J. F., Whitsett, J. A., Lindstrom, J., & Spindel, E. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5232 · Cited by 311
Self-citationMaternal Smoking During Pregnancy. Effects on Lung Function During the First 18 Months of Life
Tager, I. B., Ngo, L. H., & Hanrahan, J. P. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.3.7663813 · Cited by 304
Research works printed but not linked: 3
- Mathews, 1998, Smoking during pregnancy, 1990–1996., Natl Vital Stat Rep, 47, 1
- Sekhon, 1998, In vitro nicotine inhibits fetal lung development and blocks the mitogenic activity of gastrin-releasing peptide (GRP) in non-human primates [abstract]., Am J Respir Crit Care Med, 157, A544
- Sekhon, 2000, Maternal nicotine exposure up-regulates collagen and elastin gene expression in fetal nonhuman primate lungs: Potential role of α7 nicotinic receptors [abstract]., Am J Respir Crit Care Med, 161, A562
Cited by
Sorted by citations
Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission
Stolz, D., Mkorombindo, T., Schumann, D., Agustí, A. G. N., Ash, S. Y., Bafadhel, M., Bai, C., Chalmers, J. D., Criner, G. J., Dharmage, S. C., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01273-9 · Cited by 738
Early-Life Origins of Chronic Obstructive Pulmonary Disease
Martínez, F. D. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1603287 · Cited by 491
Early life origins of chronic obstructive pulmonary disease
Svanes, C., Sunyer, J., Plana, E., Dharmage, S., Heinrich, J., Jarvis, D., de Marco, R., Norback, D., Raherison, C., Villani, S., et al. (2010) · Thorax · doi:10.1136/thx.2008.112136 · Cited by 466
Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review
Bruin, J. E., Gerstein, H. C., & Holloway, A. C. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq103 · Cited by 379
Nicotine and the Developing Human
England, L. J., Bunnell, R. E., Pechacek, T. F., Tong, V. T., & McAfee, T. A. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.01.015 · Cited by 320
Metadata
- Authors
- SEKHON, H. S., KELLER, J. A., BENOWITZ, N. L., & SPINDEL, E. R.
- Affiliations
- Oregon Health & Science University (US)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09
- Volume
- 164
- Issue
- 6
- Pages
- 989-994
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2053834750
- Cited by
- 182
- References
- 49
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 9 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 19 · 2019: 4 · 2018: 11 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 12 · 2013: 5 · 2012: 8
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR-00163.)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD/HL-37131)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- prenatal nicotine exposure, smoking during pregnancy, lung function, rhesus monkeys, nicotinic acetylcholine receptors, fetal lung development, lung mechanics, pulmonary resistance, lung compliance, lung weight, neonates, fetal lung
- MeSH terms
- Amniotic Fluid, Animals, Animals, Newborn, Body Weight, Chromatography, Gas, Cotinine, Data Interpretation, Statistical, Female, Fetus, Humans, Infant, Newborn, Lung, Lung Compliance, Macaca mulatta, Nicotine, Pregnancy, Respiratory Function Tests, Smoking, Mass Spectrometry
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
