The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
KL-6, a Mucin-like Glycoprotein, in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease
Abstract
KL-6, a mucin-like high-molecular-weight glycoprotein, is a serum marker indicating the disease activity of pneumonitis, such as idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis, and sarcoidosis. Immunohistochemical studies have shown that KL-6 is strongly expressed on Type 2 pneumocytes and also exists on epithelial cells in other organs. It has not been clarified whether the increased levels of KL-6 in sera from patients with pneumonitis are derived from the lower respiratory tract. In this study, KL-6 levels were evaluated in bronchoalveolar lavage fluid (BALF) samples from 9 healthy control subjects and 32 patients with interstitial pneumonitis. An abnormally high level of KL-6 in BALF was observed in 70% (7 of 10) of patients with IPF, 64% (9 of 14) of patients with sarcoidosis, and 100% (8 of 8) of patients with hypersensitivity pneumonitis but in none of the healthy control subjects. KL-6 levels in BALF were significantly correlated with numbers of total cells (p < 0.001), lymphocytes (p < 0.001), and neutrophils (p < 0.05) and with concentrations of albumin (p < 0.001) and total protein (p < 0.001) in BALF and, further, with serum KL-6 levels (p < 0.01). These results indicate that increased levels of serum KL-6 in patients with pneumonitis reflect the production levels of KL-6 derived from damaged or regenerating Type 2 pneumocytes in the lower respiratory tract.
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Cites
Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution
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New Serum Indicator of Interstitial Pneumonitis Activity
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Structural Features of Interstitial Lung Disease in Systemic Sclerosis
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Cited by
Lung Epithelium–specific Proteins: Characteristics and Potential Applications as Markers
HERMANS, C., & BERNARD, A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.2.9806064 · Cited by 428
OHNISHI, H., YOKOYAMA, A., KONDO, K., HAMADA, H., ABE, M., NISHIMURA, K., HIWADA, K., & KOHNO, N. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.3.2107134 · Cited by 398
Self-citationInoue, Y., Kaner, R. J., Guiot, J., Maher, T. M., Tomassetti, S., Moiseev, S., Kuwana, M., & Brown, K. K. (2020) · Chest · doi:10.1016/j.chest.2020.03.037 · Cited by 133
Self-citationBiomarkers in idiopathic pulmonary fibrosis
Drakopanagiotakis, F., Wujak, L., Wygrecka, M., & Markart, P. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.023 · Cited by 132
Metadata
- Authors
- Kohno, N., Awaya, Y., Oyama, T., Yamakido, M., Akiyama, M., Inoue, Y., Yokoyama, A., Hamada, H., Fujioka, S., & Hiwada, K.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-09
- Volume
- 148
- Issue
- 3
- Pages
- 637-642
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W2143997148
- Cited by
- 286
- References
- 23
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: KL-6, a Mucin-like Glycoprotein, in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease. https://app.cochat.ai/papers/10.1164/ajrccm/148.3.637
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- Kohno, N., Awaya, Y., Oyama, T., Yamakido, M., Akiyama, M., Inoue, Y., Yokoyama, A., Hamada, H., Fujioka, S., & Hiwada, K. (1993). KL-6, a Mucin-like Glycoprotein, in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease. American Review of Respiratory Disease. https://doi.org/10.1164/ajrccm/148.3.637
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