The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
A Prospective, Controlled Trial of a Protocol-based Strategy to Discontinue Mechanical Ventilation
Abstract
Weaning protocols can improve outcomes, but their efficacy may vary with patient and staff characteristics. In this prospective, controlled trial, we compared protocol-based weaning to usual, physician-directed weaning in a closed medical intensive care unit (ICU) with high physician staffing levels and structured, system-based rounds. Adult patients requiring mechanical ventilation for more than 24 hours were assigned to usual care (UC) or protocol weaning based on their hospital identification number. Patients assigned to UC (n=145) were managed at their physicians' discretion. Patients assigned to protocol (n=154) underwent daily screening and a spontaneous breathing trial by respiratory and nursing staff without physician intervention. There were no significant baseline differences in patient characteristics between groups. The proportion of patients (protocol vs. UC) who successfully discontinued mechanical ventilation (74.7% vs. 75.2%, p=0.92), duration of mechanical ventilation (median [interquartile range]: 60.4 hours [28.6-167.0 hours] vs. 68.0 hours [27.1-169.3 hours], p=0.61), ICU (25.3% vs. 28.3%) and hospital mortality (36.4% vs. 33.1%), ICU length of stay (115 vs. 146 hours), and rates of reinstituting mechanical ventilation (10.3% vs. 9.0%) was similar. We conclude that protocol-directed weaning may be unnecessary in a closed ICU with generous physician staffing and structured rounds.
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Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Hospital Nurse Staffing and Patient Mortality, Nurse Burnout, and Job Dissatisfaction
Aiken, L. H. (2002) · JAMA · doi:10.1001/jama.288.16.1987 · Cited by 5,226
Controlled Sedation with Alphaxalone-Alphadolone
Ramsay, M. A. E., Savege, T. M., Simpson, B. R. J., & Goodwin, R. (1974) · BMJ · doi:10.1136/bmj.2.5920.656 · Cited by 2,861
Nurse-Staffing Levels and the Quality of Care in Hospitals
Needleman, J., Buerhaus, P., Mattke, S., Stewart, M., & Zelevinsky, K. (2002) · New England Journal of Medicine · doi:10.1056/nejmsa012247 · Cited by 2,241
Physician Staffing Patterns and Clinical Outcomes in Critically Ill Patients: A Systematic Review
Pronovost, P. J., Angus, D. C., Dorman, T., Robinson, K. A., Dremsizov, T. T., & Young, T. L. (2002) · JAMA · doi:10.1001/jama.288.17.2151 · Cited by 1,506
Ely, E. W., Baker, A. M., Dunagan, D. P., Burke, H. L., Smith, A. C., Kelly, P. T., Johnson, M. M., Browder, R. W., Bowton, D. L., & Haponik, E. F. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612193352502 · Cited by 1,346
Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation
Brook, A. D., Ahrens, T. S., Schaiff, R., Prentice, D., Sherman, G., Shannon, W., & Kollef, M. H. (1999) · Critical Care Medicine · doi:10.1097/00003246-199912000-00001 · Cited by 1,013
Esley, E. W., Ly, E., Aker, M., Unagan, D. O. P. D., Urke, L. B., Mith, C. S., Atrick, P., Elly, T. K., Argaret, M., Ohnson, M. J., et al. (1996) · Cited by 950
Kollef, M. H., Shapiro, S. D., Silver, P., St. John, R. E., Prentice, D., Sauer, S., Ahrens, T. S., Shannon, W., & Baker-Clinkscale, D. (1997) · Critical Care Medicine · doi:10.1097/00003246-199704000-00004 · Cited by 827
ESTEBAN, A., ALÍA, I., TOBIN, M. J., GIL, A., GORDO, F., VALLVERDÚ, I., BLANCH, L., BONET, A., VÁZQUEZ, A., de PABLO, R., et al. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.2.9803106 · Cited by 773
Cited by
Weaning from mechanical ventilation
Boles, J.-M., Bion, J., Connors, A., Herridge, M., Marsh, B., Melot, C., Pearl, R., Silverman, H., Stanchina, M., Vieillard-Baron, A., et al. (2007) · European Respiratory Journal · doi:10.1183/09031936.00010206 · Cited by 2,064
The ABCDEF Bundle: Science and Philosophy of How ICU Liberation Serves Patients and Families
Ely, E. W. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002175 · Cited by 514
A Multicenter Randomized Trial of Computer-driven Protocolized Weaning from Mechanical Ventilation
Lellouche, F., Mancebo, J., Jolliet, P., Roeseler, J., Schortgen, F., Dojat, M., Cabello, B., Bouadma, L., Rodriguez, P., Maggiore, S., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200511-1780oc · Cited by 406
Girard, T. D., Alhazzani, W., Kress, J. P., Ouellette, D. R., Schmidt, G. A., Truwit, J. D., Burns, S. M., Epstein, S. K., Esteban, A., Fan, E., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201610-2075st · Cited by 387
Blackwood, B., Burns, K. E., Cardwell, C. R., & O'Halloran, P. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006904.pub3 · Cited by 285
Metadata
- Authors
- Krishnan, J. A., Moore, D., Robeson, C., Rand, C. S., & Fessler, H. E.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-15
- Volume
- 169
- Issue
- 6
- Pages
- 673-678
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2153664242
- Cited by
- 309
- References
- 23
- FWCI
- 17.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Krishnan, J. A., Moore, D., Robeson, C., Rand, C. S., & Fessler, H. E. (2004). A Prospective, Controlled Trial of a Protocol-based Strategy to Discontinue Mechanical Ventilation. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200306-761oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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