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Cited by 386

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Airway Remodeling and Inflammation in Symptomatic Infants with Reversible Airflow Obstruction

Saglani, Sejal, Malmström, Kristiina, Pelkonen, Anna S., Malmberg, L. Pekka, Lindahl, Harry, Kajosaari, Merja, Turpeinen, Markku, Rogers, Andrew V., Payne, Donald N., Bush, Andrew, Haahtela, Tari, Mäkelä, Mika J., Jeffery, Peter K.·2005·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200410-1404oc
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Abstract

RATIONALE: We hypothesized that the epithelial reticular basement membrane (RBM) thickening and eosinophilic inflammation characteristic of asthma would be present in symptomatic infants with reversible airflow obstruction. METHODS: RBM thickness and numbers of inflammatory cells were determined in ultrathin sections of endobronchial biopsies obtained from 53 infants during clinical bronchoscopy for severe wheeze and/or cough. Group A: 16 infants with a median age of 12 months (range 3.4-26 months), with decreased specific airway conductance (sGaw) and bronchodilator reversibility; Group B: 22 infants with a median age of 12.4 months (5.1-25.9 months), with decreased sGaw but without bronchodilator reversibility; and Group C: 15 infants with a median age of 11.5 months (3.4-24.3 months) with normal sGaw. Additional comparisons were made with the following groups. Group D: 17 children, median age 10.3 years (6-16 years), with difficult asthma; Group E: 10 pediatric control subjects without asthma, median age 10 years (6-16 years); and Group F: nine adult normal, healthy control subjects, median age 27 years (21-42 years). MAIN RESULTS: There were no significant differences in RBM thickness or inflammatory cell number between the infant groups. RBM thickness was similar in the infants and Groups E and F. However, the RBM in all infant groups (Group A: median 4.3 microm [range 2.8-9.2 microm]; Group B: median 4.15 microm [range 2.7-5.8 microm]; Group C: median 3.8 microm [range 2.7-5.5 microm]) was significantly less thick than that in the older children with asthma (Group D: median 8.3 microm [range 5.3-12.7 microm]; p < 0.001). CONCLUSION: RBM thickening and the eosinophilic inflammation characteristic of asthma in older children and adults are not present in symptomatic infants with reversible airflow obstruction, even in the presence of atopy.

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Metadata

Authors
Saglani, S., Malmström, K., Pelkonen, A. S., Malmberg, L. P., Lindahl, H., Kajosaari, M., Turpeinen, M., Rogers, A. V., Payne, D. N., Bush, A., Haahtela, T., Mäkelä, M. J., & Jeffery, P. K.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2005-04-01
Volume
171
Issue
7
Pages
722-727
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200410-1404oc
OpenAlex
W2131770075
Cited by
386
References
29
FWCI
19.52
Type
journal article
Language
en
Open access
closed

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The paper
Saglani, S., Malmström, K., Pelkonen, A. S., Malmberg, L. P., Lindahl, H., Kajosaari, M., Turpeinen, M., Rogers, A. V., Payne, D. N., Bush, A., Haahtela, T., Mäkelä, M. J., & Jeffery, P. K. (2005). Airway Remodeling and Inflammation in Symptomatic Infants with Reversible Airflow Obstruction. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200410-1404oc

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.