Cited by 509Respiratory Support and MechanismsNeonatal Respiratory Health ResearchNosocomial Infections in ICU

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Tidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High

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Hager, David N., Krishnan, Jerry A., Hayden, Douglas L., Brower, Roy G.·2005·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.200501-048cpPMC PMC2718413

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Abstract

Use of a volume- and pressure-limited mechanical ventilation strategy improves clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). However, the extent to which tidal volumes and inspiratory airway pressures should be reduced to optimize clinical outcomes is a controversial topic. This article addresses the question, “Is there a safe upper limit to inspiratory plateau pressure in patients with ALI/ARDS?” We reviewed data from animal models with and without preexisting lung injury, studies of normal human respiratory system mechanics, and the results of five clinical trials of lung-protective mechanical ventilation strategies. We also present an original analysis of data from the largest of the five clinical trials. The available data from each of these assessments do not support the commonly held view that inspiratory plateau pressures of 30 to 35 cm H2O are safe. We could not identify a safe upper limit for plateau pressures in patients with ALI/ARDS.

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Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Robust Locally Weighted Regression and Smoothing Scatterplots
Cleveland, W. S. (1979) · Journal of the American Statistical Association · doi:10.1080/01621459.1979.10481038 · Cited by 11,594
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
The APACHE III Prognostic System
Knaus, W. A., Wagner, D. P., Draper, E. A., Zimmerman, J. E., Bergner, M., BASTOS, P. G., Sirio, C., Murphy, D. J., Lotring, T., Damiano, A., et al. (1991) · CHEST Journal · doi:10.1378/chest.100.6.1619 · Cited by 3,539
The APACHE III Prognostic System
Teres, D., & Lemeshow, S. A. (1992) · CHEST Journal · doi:10.1378/chest.102.6.1919b · Cited by 2,896
Ventilator-induced Lung Injury: Lessons from Experimental Studies
Dreyfuss, D., & Saumon, G. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9604014 · Cited by 2,262
High Inflation Pressure Pulmonary Edema: Respective Effects of High Airway Pressure, High Tidal Volume, and Positive End-expiratory Pressure
Dreyfuss, D., Soler, P., Basset, G., & Saumon, G. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.5.1159 · Cited by 1,714
Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure.
Hh, W., & Tierney, D. F. (1974) · PubMed · doi:10.1164/arrd.1974.110.5.556 · Cited by 944
Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome
Hickling, K. G., Henderson, S. J., & Jackson, R. (1990) · Intensive Care Medicine · doi:10.1007/bf01735174 · Cited by 923
Evaluation of a Ventilation Strategy to Prevent Barotrauma in Patients at High Risk for Acute Respiratory Distress Syndrome
Stewart, T. E., Meade, M. O., Cook, D. J., Granton, J. T., Hodder, R. V., Lapinsky, S. E., Mazer, C. D., McLean, R. F., Rogovein, T. S., Schouten, B. D., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380603 · Cited by 873

Show all 45 references

Research works printed but not linked: 46

1993, Chest, 1833
2005, Crit Care Med, 925
1998, N Engl J Med, 347
2000, N Engl J Med, 1301
1990, Intensive Care Med, 372
2002, Am J Respir Crit Care Med, 242
2001, Crit Care Med, 392
2003, Am J Respir Crit Care Med, 933
2005, Crit Care Med, 1141
2003, Eur Respir J Suppl, 15s
2002, Am J Respir Crit Care Med, 1510
2000, N Engl J Med, 1360
2003, Am J Respir Crit Care Med, 1297
2002, Am J Respir Crit Care Med, 1510
2002, Am J Respir Crit Care Med, 933
2002, Intensive Care Med, 230
2002, Am J Respir Crit Care Med, 1515
2004, Chest, 592
1998, Am J Respir Crit Care Med, 294
1993, Crit Care Med, 131
1946, Am J Physiol, 161
1998, N Engl J Med, 355
1999, Crit Care Med, 1492
1998, Am J Respir Crit Care Med, 1831
2003, Am J Respir Crit Care Med, A616
1993, J Pediatr Surg, 488
1988, Am Rev Respir Dis, 1159
1974, Am Rev Respir Dis, 556
1993, J Appl Physiol, 3068
1988, Intensive Care Med, 8
1990, J Appl Physiol, 956
1984, J Appl Physiol, 1809
1990, Am Rev Respir Dis, 321
1990, J Appl Physiol, 577
2004, JAMA, 1603
1993, New Horiz, 489
2005, Ann Intern Med, 283
2002, Crit Care Clin, 1
2003, Am J Respir Crit Care Med, 612
1990, Crit Care Med, 103
1991, Chest, 1619
2000, Am J Respir Crit Care Med, 209
1994, Am J Respir Crit Care Med, 1722
1971, J Appl Physiol, 909
2005, Crit Care Med, 1143
1979, J Am Stat Assoc, 829

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Dunne, P. J., MacIntyre, N. R., Schmidt, U. H., Haas, C. F., Rye, K. J.-B., Kauffman, G. W., & HESS, D. R. (2012) · Respiratory Care · doi:10.4187/respcare.01776 · Cited by 9
Acute Respiratory Distress Syndrome: Current Concepts and Future Directions
Fröhlich, S., Murphy, N., Ryan, D., & Boylan, J. F. (2013) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1304100405 · Cited by 8
Independent lung ventilation in a newborn with asymmetric acute lung injury due to respiratory syncytial virus: a case report
Nardo, M. D., Perrotta, D., Stoppa, F., Cecchetti, C., Marano, M., & Pirozzi, N. (2008) · Journal of Medical Case Reports · doi:10.1186/1752-1947-2-212 · Cited by 8
Pressure-controlled inverse ratio ventilation as a rescue therapy for severe acute respiratory distress syndrome
Kotani, T., Katayama, S., Fukuda, S., Miyazaki, Y., & Sato, Y. (2016) · SpringerPlus · doi:10.1186/s40064-016-2440-x · Cited by 8
Low-dose perfluorocarbon: A revival for partial liquid ventilation?*
Lemaire, F. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000255159.86982.b5 · Cited by 8
Role of extracorporeal membrane oxygenation in adult respiratory failure: an overview
Anand, S., Jayakumar, D., Aronow, W. S., & Chandy, D. (2016) · Hospital Practice · doi:10.1080/21548331.2016.1151325 · Cited by 7
Managing a patient with Acute Respiratory Distress Syndrome PART 1
Lian, J. X. (2010) · Nursing Critical Care · doi:10.1097/01.ccn.0000389644.61365.26 · Cited by 7
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David, M., Bodenstein, M., & Markstaller, K. (2010) · Der Anaesthesist · doi:10.1007/s00101-010-1743-5 · Cited by 7
Can we prevent the spread of focal lung inflammation?
Marini, J. J. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181f20f01 · Cited by 7
Extracorporeal Membrane Oxygenation for ARDS: Optimization of Lung Protective Ventilation
Parekh, M. J., Abrams, D. C., Brodie, D., & Yip, N. H. (2018) · Respiratory Care · doi:10.4187/respcare.06262 · Cited by 7
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Zakhary, B., Fan, E., & Slutsky, A. S. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003835 · Cited by 7
Extrakorporale Membranoxygenierung
Staudinger, T. (2017) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-017-0279-8 · Cited by 7
High-frequency oscillation combined with arteriovenous extracorporeal lung assist reduces lung injury
Muellenbach, R. M., Kredel, M., Wilhelm, J., Küstermann, J., Fink, L., Siebenliest, G., Klosterhalfen, B., Foerster, C. Y., Kranke, P., Wunder, C., et al. (2010) · Experimental Lung Research · doi:10.3109/01902140903214683 · Cited by 7
New Goals for Positive End-Expiratory Pressure in Acute Respiratory Distress Syndrome: A Paradigm Shift or the End of an Area of Uncertainty?
Brochard, L. J. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0039ed · Cited by 7
A Metabolic Window into Acute Respiratory Distress Syndrome: Stretch, the “Baby” Lung, and Atelectrauma
Bersten, A. D., & Kavanagh, B. P. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201102-0355ed · Cited by 7
Novel Phenotypes in Respiratory Failure: Same As It Ever Was
Hardin, C. C. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202008-3322ed · Cited by 7
The Staying Power of Pressure- and Volume-limited Ventilation in Acute Respiratory Distress Syndrome
Beitler, J. R., & Walkey, A. J. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202104-0839ed · Cited by 7
The role of extracorporeal CO2 removal from pathophysiology to clinical applications with focus on potential combination with RRT: an expert opinion document
Parrilla-Gómez, F. J., Castelli, A., Colombo, R., do Vale-Fernandes, A., Nalesso, F., Pestaña-Lagunas, D., Suárez-Sipmann, F., & Terragni, P. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1651213 · Cited by 6
Dynamics of acute respiratory distress syndrome development due to smoke inhalation injury: Implications for prolonged field care
Batchinsky, A. I., Wyckoff, R., Choi, J.-H., Burmeister, D. M., Jordan, B. S., Necsoiu, C. N., Burkett, S. E., Morris, M. J., Chung, K. K., & Cancio, L. C. (2019) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000002227 · Cited by 6
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Mart, M. F., & Ely, E. W. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004627 · Cited by 6
Comparison of the Mapleson C system and adult and paediatric self‐inflating bags for delivering guideline‐consistent ventilation during simulated adult cardiopulmonary resuscitation*
Sherren, P. B., Lewinsohn, A., Jovaiša, T., & Wijayatilake, D. S. (2011) · Anaesthesia · doi:10.1111/j.1365-2044.2011.06695.x · Cited by 6
Managing a severe acute asthma exacerbation
Lian, J. X. (2009) · Nursing Critical Care · doi:10.1097/01.ccn.0000347126.85951.9d · Cited by 6
Helmet NIV in Acute Hypoxemic Respiratory Failure due to COVID-19: Change in PaO2/FiO2 Ratio a Predictor of Success
Gupta, R., Mehra, S., Sircar, M., Jha, O. K., & Kumar, S. (2021) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-23992 · Cited by 6

Authors: Hager, D. N., Krishnan, J. A., Hayden, D. L., & Brower, R. G.
Affiliations: Johns Hopkins University (US)
ORCID: Hager, David N.
Krishnan, Jerry A.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2005-11
Volume: 172
Issue: 10
Pages: 1241-1245
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.200501-048cp
PMC: PMC2718413
OpenAlex: W2168829312
Cited by: 509
References: 45
Citations by year: 2026: 5 · 2025: 5 · 2024: 12 · 2023: 7 · 2022: 17 · 2021: 28 · 2020: 29 · 2019: 25 · 2018: 16 · 2017: 34 · 2016: 28 · 2015: 34 · 2014: 34 · 2013: 29 · 2012: 30
FWCI: 4.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hr046063-006, n01hr046064-009)
National Heart, Lung, and Blood Institute (K23HL067850, N01-HR-46063, K23-HL67850, P50HL073944, N01-HR46064, F32HL078132)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: acute lung injury, acute respiratory distress syndrome, tidal volume reduction, plateau pressure, lung-protective ventilation, pressure-limited ventilation, ventilator-induced lung injury, respiratory mechanics, animal models of lung injury
MeSH terms: Animals, Humans, Respiration, Artificial, Respiratory Distress Syndrome, Tidal Volume, Logistic Models, Models, Animal

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Tidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High

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