The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Arterial Stiffness Is Independently Associated with Emphysema Severity in Patients with Chronic Obstructive Pulmonary Disease
Open accessAbstract
RATIONALE: More patients with chronic obstructive pulmonary disease (COPD) die of cardiovascular causes than of respiratory causes, and patients with COPD have increased morbidity and mortality from stroke and coronary heart disease. Arterial stiffness independently predicts cardiovascular risk, is associated with atheromatous plaque burden, and is increased in patients with COPD compared with control subjects matched for cardiovascular risk factors. Elastin fragmentation and changes in collagen are found in the connective tissue of both emphysematous lungs and stiff arteries, but it is not known whether the severity of arterial stiffness in patients with COPD is associated with the severity of emphysema. OBJECTIVES: To identify whether the extent of arterial stiffness is associated with emphysema severity. METHODS: We performed a cross-sectional study in 157 patients with COPD. MEASUREMENTS AND MAIN RESULTS: We measured pulse wave velocity (a validated measure of arterial stiffness), blood pressure, smoking pack-years, glucose, cholesterol, and C-reactive protein in 157 patients with COPD. We assessed emphysema using quantitative computed tomography scanning in a subgroup of 73 patients. We found that emphysema severity was associated with arterial stiffness (r = 0.471, P < 0.001). The association was independent of smoking, age, sex, FEV(1)% predicted, highly sensitive C-reactive protein and glucose concentrations, cholesterol-high-density lipoprotein ratio, and pulse oximetry oxygen saturations. CONCLUSIONS: Emphysema severity is associated with arterial stiffness in patients with COPD. Similar pathophysiological processes may be involved in both lung and arterial tissue and further studies are now required to identify the mechanism underlying this newly described association.
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Cites
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ATS Statement: Guidelines for the Six-Minute Walk Test
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Expert consensus document on arterial stiffness: methodological issues and clinical applications
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
Mattace-Raso, F. U. S., van der Cammen, T. J. M., Hofman, A., van Popele, N. M., Bos, M. L., Schalekamp, M. A. D. H., Asmar, R., Reneman, R. S., Hoeks, A. P. G., Breteler, M. M. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.555235 · Cited by 1,914 · cited 5×
“Heart rate 69 (11) 69 (10) 69 (11) Systolic pressure, mm Hg 144 (23) 144 (24) 144 (21) Diastolic pressure, mm Hg 81 (11) 80 ( 11 ) 81 (12) Pulse pressure, mm Hg 64 (19) 64 (20) 63 (17) Mean arterial pressure, mm Hg 102 (13) 101 (12) 102 (13) Pulse wave velocity, m/s 8.69 (1.51) 8.55 (1.52) 8.85 (1.50)”
BackgroundInfluentialMechanisms, Pathophysiology, and Therapy of Arterial Stiffness
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Cited by
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0218pp · Cited by 3,187
Chronic obstructive pulmonary disease
Rabe, K. F., & Watz, H. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31222-9 · Cited by 960
Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort
Miller, J., Edwards, L. D., Agustí, A., Bakke, P., Calverley, P. M. A., Celli, B., Coxson, H. O., Crim, C., Lomas, D. A., Miller, B. E., et al. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.05.001 · Cited by 437
Self-citationAnnual Change in Pulmonary Function and Clinical Phenotype in Chronic Obstructive Pulmonary Disease
Nishimura, M., Makita, H., Nagai, K., Konno, S., Nasuhara, Y., Hasegawa, M., Shimizu, K., Betsuyaku, T., Ito, Y. M., Fuke, S., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201106-0992oc · Cited by 344
Metadata
- Authors
- McAllister, D. A., Maclay, J. D., Mills, N. L., Mair, G., Miller, J., Anderson, D., Newby, D. E., Murchison, J. T., & MacNee, W.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-15
- Volume
- 176
- Issue
- 12
- Pages
- 1208-1214
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1987138414
- Cited by
- 292
- References
- 48
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Arterial Stiffness Is Independently Associated with Emphysema Severity in Patients with Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1164/rccm.200707-1080oc
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- McAllister, D. A., Maclay, J. D., Mills, N. L., Mair, G., Miller, J., Anderson, D., Newby, D. E., Murchison, J. T., & MacNee, W. (2007). Arterial Stiffness Is Independently Associated with Emphysema Severity in Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200707-1080oc
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