The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Cigarette Smoking Is Associated with Subclinical Parenchymal Lung Disease: The Multi-Ethnic Study of Atherosclerosis (MESA)–Lung Study
Open accessAbstract
RATIONALE: Cigarette smoking is a risk factor for diffuse parenchymal lung disease. Risk factors for subclinical parenchymal lung disease have not been described. OBJECTIVES: To determine if cigarette smoking is associated with subclinical parenchymal lung disease, as measured by spirometric restriction and regions of high attenuation on computed tomography (CT) imaging. METHODS: We examined 2,563 adults without airflow obstruction or clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis, a population-based cohort sampled from six communities in the United States. Cumulative and current cigarette smoking were assessed by pack-years and urine cotinine, respectively. Spirometric restriction was defined as a forced vital capacity less than the lower limit of normal. High attenuation areas on the lung fields of cardiac CT scans were defined as regions having an attenuation between -600 and -250 Hounsfield units, reflecting ground-glass and reticular abnormalities. Generalized additive models were used to adjust for age, gender, race/ethnicity, smoking status, anthropometrics, center, and CT scan parameters. MEASUREMENTS AND MAIN RESULTS: The prevalence of spirometric restriction was 10.0% (95% confidence interval [CI], 8.9-11.2%) and increased relatively by 8% (95% CI, 3-12%) for each 10 cigarette pack-years in multivariate analysis. The median volume of high attenuation areas was 119 cm(3) (interquartile range, 100-143 cm(3)). The volume of high attenuation areas increased by 1.6 cm(3) (95% CI, 0.9-2.4 cm(3)) for each 10 cigarette pack-years in multivariate analysis. CONCLUSIONS: Smoking may cause subclinical parenchymal lung disease detectable by spirometry and CT imaging, even among a generally healthy cohort.
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Spirometric Reference Values from a Sample of the General U.S. Population
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Lynch, D. A., Austin, J. H. M., Hogg, J. C., Grenier, P. A., Kauczor, H.-U., Bankier, A. A., Barr, R. G., Colby, T. V., Galvin, J. R., Gevenois, P. A., et al. (2015) · Radiology · doi:10.1148/radiol.2015141579 · Cited by 658
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Putman, R. K., Hatabu, H., Araki, T., Gudmundsson, G., Gao, W., Nishino, M., Okajima, Y., Dupuis, J., Latourelle, J. C., Cho, M. H., et al. (2016) · JAMA · doi:10.1001/jama.2016.0518 · Cited by 473
Self-citationBuendia-Roldan, I., Machuca, N., Mejía, M., Maldonado, M., Pardo, A., & Selman, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-47199-0 · Cited by 33
Metadata
- Authors
- Lederer, D. J., Enright, P. L., Kawut, S. M., Hoffman, E. A., Hunninghake, G., van Beek, E. J. R., Austin, J. H. M., Jiang, R., Lovasi, G. S., & Barr, R. G.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09-01
- Volume
- 180
- Issue
- 5
- Pages
- 407-414
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2006750439
- Cited by
- 270
- References
- 44
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Lederer, D. J., Enright, P. L., Kawut, S. M., Hoffman, E. A., Hunninghake, G., van Beek, E. J. R., Austin, J. H. M., Jiang, R., Lovasi, G. S., & Barr, R. G. (2009). Cigarette Smoking Is Associated with Subclinical Parenchymal Lung Disease: The Multi-Ethnic Study of Atherosclerosis (MESA)–Lung Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200812-1966oc
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