The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Lung Opening and Closing during Ventilation of Acute Respiratory Distress Syndrome
Open accessAbstract
RATIONALE: The effects of high positive end-expiratory pressure (PEEP) strictly depend on lung recruitability, which varies widely during acute respiratory distress syndrome (ARDS). Unfortunately, increasing PEEP may lead to opposing effects on two main factors potentially worsening the lung injury, that is, alveolar strain and intratidal opening and closing, being detrimental (increasing the former) or beneficial (decreasing the latter). OBJECTIVES: To investigate how lung recruitability influences alveolar strain and intratidal opening and closing after the application of high PEEP. METHODS: We analyzed data from a database of 68 patients with acute lung injury or ARDS who underwent whole-lung computed tomography at 5, 15, and 45 cm H(2)O airway pressure. MEASUREMENTS AND MAIN RESULTS: End-inspiratory nonaerated lung tissue was estimated from computed tomography pressure-volume curves. Alveolar strain and opening and closing lung tissue were computed at 5 and 15 cm H(2)O PEEP. In patients with a higher percentage of potentially recruitable lung, the increase in PEEP markedly reduced opening and closing lung tissue (P < 0.001), whereas no differences were observed in patients with a lower percentage of potentially recruitable lung. In contrast, alveolar strain similarly increased in the two groups (P = 0.89). Opening and closing lung tissue was distributed mainly in the dependent and hilar lung regions, and it appeared to be an independent risk factor for death (odds ratio, 1.10 for each 10-g increase). CONCLUSIONS: In ARDS, especially in patients with higher lung recruitability, the beneficial impact of reducing intratidal alveolar opening and closing by increasing PEEP prevails over the effects of increasing alveolar strain.
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Cites
Le Gall, J.-R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.270.24.2957 · Cited by 7,773
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746
ACUTE RESPIRATORY DISTRESS IN ADULTS
Ashbaugh, D., Boyd Bigelow, D., Petty, T., & Levine, B. (1967) · The Lancet · doi:10.1016/s0140-6736(67)90168-7 · Cited by 4,278
(2004) · New England Journal of Medicine · doi:10.1056/nejmoa032193 · Cited by 2,565
Ventilator-induced Lung Injury: Lessons from Experimental Studies
DREYFUSS, D., & SAUMON, G. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9604014 · Cited by 2,297
Dreyfuss, D., Soler, P., Basset, G., & Saumon, G. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.5.1159 · Cited by 1,717
Lung recruitment in patients with the acute respiratory distress syndrome.
Gattinoni, L., Caironi, P., Cressoni, M., Chiumello, D., Ranieri, V. M., Quintel, M., Russo, S., Patroniti, N., Cornejo, R., & Bugedo, G. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052052 · Cited by 1,548
Self-citationStress distribution in lungs: a model of pulmonary elasticity.
Mead, J., Takishima, T., & Leith, D. (1970) · Journal of Applied Physiology · doi:10.1152/jappl.1970.28.5.596 · Cited by 1,410
Meade, M. O., Cook, D. J., Guyatt, G. H., Slutsky, A. S., Arabi, Y. M., Cooper, D. J., Davies, A. R., Hand, L. E., Zhou, Q., Thabane, L., et al. (2008) · JAMA · doi:10.1001/jama.299.6.637 · Cited by 1,370
Mercat, A., Richard, J.-C. M., Vielle, B., Jaber, S., Osman, D., Diehl, J.-L., Lefrant, J.-Y., Prat, G., Richecoeur, J., Nieszkowska, A., et al. (2008) · JAMA · doi:10.1001/jama.299.6.646 · Cited by 1,344
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Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation
Esteban, A., Frutos-Vivar, F., Muriel, A., Ferguson, N. D., Peñuelas, O., Abraira, V., Raymondos, K., Rios, F., Nin, N., Apezteguía, C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2169oc · Cited by 676
Neto, A. S., Hemmes, S. N. T., Barbas, C. S. V., Beiderlinden, M., Fernandez-Bustamante, A., Futier, E., Gajic, O., El-Tahan, M. R., Ghamdi, A. A. A., Günay, E., et al. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)00057-6 · Cited by 615
Beitler, J. R., Sarge, T., Banner-Goodspeed, V. M., Gong, M. N., Cook, D., Novack, V., Loring, S. H., Talmor, D., & for the EPVent-2 Study Group (2019) · JAMA · doi:10.1001/jama.2019.0555 · Cited by 469
Lung Stress and Strain during Mechanical Ventilation: Any Safe Threshold?
Protti, A., Cressoni, M., Santini, A., Langer, T., Mietto, C., Febres, D., Chierichetti, M., Coppola, S., Conte, G., Gatti, S., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1757oc · Cited by 346
Self-citationThe "baby lung" became an adult
Gattinoni, L., Marini, J. J., Pesenti, A., Quintel, M., Mancebo, J., & Brochard, L. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4200-8 · Cited by 304
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Metadata
- Authors
- Caironi, P., Cressoni, M., Chiumello, D., Ranieri, M., Quintel, M., Russo, S. G., Cornejo, R., Bugedo, G., Carlesso, E., Russo, R., Caspani, L., & Gattinoni, L.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-15
- Volume
- 181
- Issue
- 6
- Pages
- 578-586
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1998808512
- Cited by
- 358
- References
- 56
- FWCI
- 19.57
- Type
- journal article
- Language
- en
- Open access
- green
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