The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Combination Biomarkers to Diagnose Sepsis in the Critically Ill Patient
Abstract
RATIONALE: Although the outcome of sepsis benefits from the prompt administration of appropriate antibiotics on correct diagnosis, the assessment of infection in critically ill patients is often a challenge for clinicians. In this setting, simple biomarkers, especially when used in combination, could prove useful. OBJECTIVES: To determine the usefulness of combination biomarkers to diagnose sepsis. METHODS: Three hundred consecutive patients were enrolled to construct a biologic score that was next validated in an independent prospective cohort of 79 critically ill patients from another center. MEASUREMENT AND MAIN RESULTS: Plasma concentrations of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and procalcitonin (PCT) were assayed, and the expression of the high-affinity immunoglobulin-Fc fragment receptor I (FcγRI) CD64 on neutrophils (polymorphonuclear [PMN] CD64 index) in flow cytometry was measured. A "bioscore" combining these biomarkers was constructed. Serum concentrations of PCT and sTREM-1 and the PMN CD64 index were higher in patients with sepsis compared with all others (P < 0.001 for the three markers). These biomarkers were all independent predictors of infection, the best receiver-operating characteristic curve being obtained for the PMN CD64 index. The performance of the bioscore, better than that of each individual biomarker, was externally confirmed in the validation cohort. CONCLUSIONS: This prospective study, including inceptive and validation cohorts of unselected intensive care unit patients, demonstrates the high performance of a bioscore combining the PMN CD64 index together with PCT and sTREM-1 serum levels in diagnosing sepsis in the critically ill patient.
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Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E., Angus, D., Cook, D., Cohen, J., Opal, S. M., Vincent, J.-L., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,995
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Vincent, J.-L. (2009) · JAMA · doi:10.1001/jama.2009.1754 · Cited by 3,618
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HARBARTH, S., HOLECKOVA, K., FROIDEVAUX, C., PITTET, D., RICOU, B., GRAU, G. E., VADAS, L., PUGIN, J., & the Geneva Sepsis Network (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.3.2009052 · Cited by 898
Use of Multiple Biomarkers to Improve the Prediction of Death from Cardiovascular Causes
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Cited by
Sepsis: a roadmap for future research
Cohen, J., Vincent, J.-L., Adhikari, N. K. J., Machado, F. R., Angus, D. C., Calandra, T., Jaton, K., Giulieri, S., Delaloye, J., Opal, S., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70112-x · Cited by 992
Faix, J. D. (2013) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2013.764490 · Cited by 663
New Approaches to Sepsis: Molecular Diagnostics and Biomarkers
Reinhart, K., Bauer, M., Riedemann, N. C., & Hartog, C. S. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-12 · Cited by 533
Djordjevic, D., Rondovic, G., Surbatovic, M., Stanojevic, I., Udovicic, I., Andjelic, T., Zeba, S., Milosavljevic, S., Stankovic, N., Abazovic, D., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/3758068 · Cited by 268
The Clinical Challenge of Sepsis Identification and Monitoring
Vincent, J.-L. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002022 · Cited by 259
Metadata
- Authors
- Gibot, S., Béné, M. C., Noel, R., Massin, F., Guy, J., Cravoisy, A., Barraud, D., De Carvalho Bittencourt, M., Quenot, J.-P., Bollaert, P.-E., Faure, G., & Charles, P.-E.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07-01
- Volume
- 186
- Issue
- 1
- Pages
- 65-71
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2107912229
- Cited by
- 294
- References
- 30
- FWCI
- 21.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gibot, S., Béné, M. C., Noel, R., Massin, F., Guy, J., Cravoisy, A., Barraud, D., De Carvalho Bittencourt, M., Quenot, J.-P., Bollaert, P.-E., Faure, G., & Charles, P.-E. (2012). Combination Biomarkers to Diagnose Sepsis in the Critically Ill Patient. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201201-0037oc
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