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Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

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Sepsis definitions: time for change

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Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis

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New Approaches to Sepsis: Molecular Diagnostics and Biomarkers

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Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial.

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A comprehensive time-course–based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set

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Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study

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Early versus delayed administration of norepinephrine in patients with septic shock

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Combination Biomarkers to Diagnose Sepsis in the Critically Ill Patient

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Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis

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Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients

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The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis

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The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: Systematic review

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A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts

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Procalcitonin Versus C-Reactive Protein for Guiding Antibiotic Therapy in Sepsis: A Randomized Trial*

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Procalcitonin for reduced antibiotic exposure in the critical care setting: A systematic review and an economic evaluation*

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Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections*

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An international sepsis survey: a study of doctors' knowledge and perception about sepsis

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Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study

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The Time Course of Blood C-reactive Protein Concentrations in Relation to the Response to Initial Antimicrobial Therapy in Patients with Sepsis

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An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

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Biomarkers of Sepsis

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Gene-expression profiling of peripheral blood mononuclear cells in sepsis*

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C-reactive protein, an early marker of community-acquired sepsis resolution: a multi-center prospective observational study

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Early increase of procalcitonin after cardiovascular surgery in patients with postoperative complications

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Gene-expression profiling of peripheral blood mononuclear cells in sepsis

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Integrative “Omic” Analysis of Experimental Bacteremia Identifies a Metabolic Signature That Distinguishes Human Sepsis from Systemic Inflammatory Response Syndromes

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Procalcitonin as a prognostic and diagnostic tool for septic complications after major trauma*

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C-Reactive Protein Kinetics After Major Surgery

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Determinants of temperature abnormalities and influence on outcome of critical illness*

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Antibiotic strategies in severe nosocomial sepsis

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Diagnostic and prognostic markers in sepsis

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Sepsis: older and newer concepts

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An evaluation of the diagnostic accuracy of the 1991 American College of Chest Physicians/Society of Critical Care Medicine and the 2001 Society of Critical Care Medicine/European Society of Intensive Care Medicine/American College of Chest Physicians/American Thoracic Society/Surgical Infection Society sepsis definition*

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Clinical evaluation of commercial nucleic acid amplification tests in patients with suspected sepsis

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16S Ribosomal Ribonucleic Acid Gene Polymerase Chain Reaction in the Diagnosis of Bloodstream Infections: A Systematic Review and Meta-Analysis

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The Pathogenesis of Sepsis and Potential Therapeutic Targets

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Sepsis: A Review of Advances in Management

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Early detection of sepsis utilizing deep learning on electronic health record event sequences

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Sepsis biomarkers and diagnostic tools with a focus on machine learning

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Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology

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Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU

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Sepsis prediction, early detection, and identification using clinical text for machine learning: a systematic review

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Non-faradaic electrochemical impedimetric profiling of procalcitonin and C-reactive protein as a dual marker biosensor for early sepsis detection

Tanak, A. S., Jagannath, B., Tamrakar, Y., Muthukumar, S., & Prasad, S. (2019) · Analytica Chimica Acta X · doi:10.1016/j.acax.2019.100029 · Cited by 118 · see citing works

Development and validation of a diagnostic model for early differentiation of sepsis and non-infectious SIRS in critically ill children - a data-driven approach using machine-learning algorithms

Lamping, F., Jack, T., Rübsamen, N., Sasse, M., Beerbaum, P., Mikolajczyk, R., Boehne, M., & Karch, A. (2018) · BMC Pediatrics · doi:10.1186/s12887-018-1082-2 · Cited by 93 · see citing works

Sepsis Alert Systems, Mortality, and Adherence in Emergency Departments

Kim, H., Ko, R., Lim, S. Y., Park, S., Suh, G. Y., & Lee, Y. J. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.22823 · Cited by 91 · see citing works

Automated prediction of sepsis using temporal convolutional network

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Epigenetics in Sepsis: Understanding Its Role in Endothelial Dysfunction, Immunosuppression, and Potential Therapeutics

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Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: a systematic review and meta-analysis

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Synthetic hydrogel nanoparticles for sepsis therapy

Koide, H., Okishima, A., Hoshino, Y., Kamon, Y., Yoshimatsu, K., Saito, K., Yamauchi, I., Ariizumi, S., Zhou, Y., Xiao, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25847-2 · Cited by 81 · see citing works

The pathophysiology of sepsis—2021 update: Part 1, immunology and coagulopathy leading to endothelial injury

Jacobi, J. (2021) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxab380 · Cited by 74 · see citing works

On classifying sepsis heterogeneity in the ICU: insight using machine learning

Ibrahim, Z. M., Wu, H., Hamoud, A., Stappen, L., Dobson, R., & Agarossi, A. (2019) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocz211 · Cited by 73 · see citing works

Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology

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Protein corona fingerprinting to differentiate sepsis from non-infectious systemic inflammation

Papafilippou, L., Claxton, A., Dark, P. M., Kostarelos, K., & Hadjidemetriou, M. (2020) · Nanoscale · doi:10.1039/d0nr02788j · Cited by 65 · see citing works

Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance

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Sepsis—A Retrospective Cohort Study of Bloodstream Infections

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Comparison of qSOFA score, SOFA score, and SIRS criteria for the prediction of infection and mortality among surgical intermediate and intensive care patients

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qSOFA is a Poor Predictor of Short-Term Mortality in All Patients: A Systematic Review of 410,000 Patients

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Accuracy of International Classification of Diseases, 10th Revision Codes for Identifying Sepsis: A Systematic Review and Meta-Analysis

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Role of Mitochondria-Derived Danger Signals Released After Injury in Systemic Inflammation and Sepsis

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The role of natriuretic peptides in the management, outcomes and prognosis of sepsis and septic shock

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Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response

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Real-Time Prediction of Sepsis in Critical Trauma Patients: Machine Learning–Based Modeling Study

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Lactate, bicarbonate and anion gap for evaluation of patients presenting with sepsis to the emergency department: A prospective cohort study

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Comparison of Differences in Cohort (Forward) and Case Control (Backward) Methodologic Approaches for Validation of the Hypotension Prediction Index

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Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria

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MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction

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Nurses' knowledge and confidence in recognizing and managing patients with sepsis: A multi‐site cross‐sectional study

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Evaluation of the host cytokine response in dogs with sepsis and noninfectious systemic inflammatory response syndrome

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Sepsis Prediction in Intensive Care Unit Using Ensemble of XGboost Models

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Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study

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Procalcitonin kinetics after burn injury and burn surgery in septic and non-septic patients – a retrospective observational study

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Dynamic Prediction of Patient Outcomes in the Intensive Care Unit: A Scoping Review of the State-of-the-Art

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Persistently elevated early warning scores and lactate identifies patients at high risk of mortality in suspected sepsis

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Continuous Label-Free Electronic Discrimination of T Cells by Activation State

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Clinical trial design for unmet clinical needs: a spotlight on sepsis

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Outer membrane vesicles as molecular biomarkers for Gram-negative sepsis: Taking advantage of nature’s perfect packages

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Infection, Sepsis and the Inflammatory Response: Mechanisms and Therapy

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Two-Stage Monitoring of Patients in Intensive Care Unit for Sepsis Prediction Using Non-Overfitted Machine Learning Models

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Impact of the Centers for Medicare and Medicaid Services sepsis core measure on antibiotic use.

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Identification and validation of key biomarkers based on RNA methylation genes in sepsis

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Validation of monocyte distribution width decisional cutoff for sepsis detection in the acute setting

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Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients

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Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients

Brakenridge, S. C., Chen, U., Loftus, T. J., Ungaro, R. F., Dirain, M. L. S., Kerr, A. W., Zhong, L., Bacher, R. L., Starostik, P., Ghita, G., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.21520 · Cited by 24 · see citing works

Development and Validation of Deep-Learning-Based Sepsis and Septic Shock Early Prediction System (DeepSEPS) Using Real-World ICU Data

Kim, T., Tae, Y., Yeo, H. J., Jang, J. H., Cho, K., Yoo, D., Lee, Y., Ahn, S., Kim, Y., Lee, N., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227156 · Cited by 30 · see citing works

Review article: Sepsis in the emergency department – Part 2: Investigations and monitoring

Shetty, A., Macdonald, S. P. J., Keijzers, G., Williams, J. M., Tang, B. M. P., de Groot, B., Thompson, K., Fraser, J. F., Finfer, S. R., Bellomo, R., et al. (2018) · Emergency Medicine Australasia · doi:10.1111/1742-6723.12924 · Cited by 24 · see citing works

Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation

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Should serial monitoring of procalcitonin be done routinely in critically ill patients of ICU

Patnaik, R., Azim, A., & Mishra, P. (2020) · Journal of Anaesthesiology Clinical Pharmacology · doi:10.4103/joacp.joacp_388_19 · Cited by 23 · see citing works

Effective prognostic and clinical risk stratification in COVID‐19 using multimodality biomarkers

Liu, A., Hammond, R., Donnelly, P., Kaski, J. C., & Coates, A. R. M. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13646 · Cited by 23 · see citing works

Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review

Barber, G., Tanic, J., & Leligdowicz, A. (2023) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000870 · Cited by 22 · see citing works

Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways

Sun, F., Xu, K., Zhou, J., Zhang, W., Duan, G., & Lei, M. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03442-1 · Cited by 21 · see citing works

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

Vasco, C. F., Watanabe, M., da Fonseca, C. D., & Vattimo, M. D. F. F. (2018) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2017-0469 · Cited by 19 · see citing works

The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis

Mewes, C., Büttner, B., Hinz, J. M., Alpert, A., Popov, A., Ghadimi, M. B., Beißbarth, T., Tzvetkov, M. V., Shen-Orr, S. S., Bergmann, I., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33246-9 · Cited by 20 · see citing works

Automated measurement of neutrophil CD64 expression for diagnosing sepsis in critically ill patients

Thiriet, C., Mahjoub, K., Courte, G., Labroca, P., Cravoisy, A., Lemarie, J., Conrad, M., Nace, L., Bollaert, P., & Gibot, S. (2019) · Minerva Anestesiologica · doi:10.23736/s0375-9393.19.13420-7 · Cited by 20 · see citing works

Implementation of Complementary Model using Optimal Combination of Hematological Parameters for Sepsis Screening in Patients with Fever

Choi, J.-S., Trinh, T. X., Ha, J., Yang, M.-S., Lee, Y., Kim, Y.-E., Choi, J., Byun, H., Song, J., & Yoon, T. H. (2020) · Scientific Reports · doi:10.1038/s41598-019-57107-1 · Cited by 20 · see citing works

Clinical management of sepsis can be improved by artificial intelligence: no

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Sepsis Prediction in Intensive Care Unit Using Ensemble of XGboost Models

Zabihi, M., Kiranyaz, M. S., & Gabbouj, M. (2019) · Qatar University QSpace (Qatar University) · doi:10.23919/cinc49843.2019.9005564 · Cited by 18 · see citing works

Evaluating the appropriateness of carbapenem and piperacillin-tazobactam prescribing in a tertiary care hospital in Saudi Arabia

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Advancements in medical diagnosis and treatment through machine learning: A review

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Deciphering sepsis: transforming diagnosis and treatment through systems immunology

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Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice

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Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model

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Enhancer polymorphism rs10865710 associated with traumatic sepsis is a regulator of PPARG gene expression

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Study of MicroRNA-122 as a Diagnostic Biomarker of Sepsis.

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Incidence and Time Point of Sepsis Detection as Related to Different Sepsis Definitions in Severely Burned Patients and Their Accompanying Time Course of Pro-Inflammatory Biomarkers

Niggemann, P., Rittirsch, D., Buehler, P. K., Schweizer, R., Giovanoli, P., Reding, T., Graf, R., Plock, J. A., & Klein, H. J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11080701 · Cited by 17 · see citing works

Nanobiosensors for procalcitonin ( PCT ) analysis

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Assessment of patients with suspected sepsis in ambulance services: a qualitative interview study

Olander, A., Bremer, A., Sundler, A. J., Hagiwara, M. A., & Andersson, H. (2021) · BMC Emergency Medicine · doi:10.1186/s12873-021-00440-4 · Cited by 16 · see citing works

Towards early sepsis detection from measurements at the general ward through deep learning

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SpyTag-PEGylated probiotics delivering IL-1Ra modulate gut-lung crosstalk to mitigate septic lung injury

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Sepsis-induced ALI/ARDS beyond supportive care: molecular mechanisms and cutting-edge therapies

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Role of Neutrophil Gelatinase-associated Lipocalin (NGAL) and Other Clinical Parameters as Predictors of Bacterial Sepsis in Patients Presenting to the Emergency Department with Fever

Gowri, M. S., Iyyadurai, R., Abhilash, K. P. P., Paul, A., Newbigging, N. S., Lenin, A., Varghese, J. S., Nell, A. J., Binu, A. J., Chandiraseharan, V. K., et al. (2023) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-24419 · Cited by 15 · see citing works

Clinical usefulness of NT-proBNP as a prognostic factor for septic shock patients presenting to the emergency department

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Comparison of machine-learning methodologies for accurate diagnosis of sepsis using microarray gene expression data

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The challenge of recognising sepsis: Future nanotechnology solutions

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High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome

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Ground truth labels challenge the validity of sepsis consensus definitions in critical illness.

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Antithrombin as Therapeutic Intervention against Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation: Lessons Learned from COVID-19-Associated Coagulopathy

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Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis

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Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model

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