The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Lung Microbiota and Bacterial Abundance in Patients with Bronchiectasis when Clinically Stable and during Exacerbation
Open accessAbstract
RATIONALE: Characterization of bacterial populations in infectious respiratory diseases will provide improved understanding of the relationship between the lung microbiota, disease pathogenesis, and treatment outcomes. OBJECTIVES: To comprehensively define lung microbiota composition during stable disease and exacerbation in patients with bronchiectasis. METHODS: Sputum was collected from patients when clinically stable and before and after completion of antibiotic treatment of exacerbations. Bacterial abundance and community composition were analyzed using anaerobic culture and 16S rDNA pyrosequencing. MEASUREMENTS AND MAIN RESULTS: In clinically stable patients, aerobic and anaerobic bacteria were detected in 40 of 40 (100%) and 33 of 40 (83%) sputum samples, respectively. The dominant organisms cultured were Pseudomonas aeruginosa (n = 10 patients), Haemophilus influenzae (n = 12), Prevotella (n = 18), and Veillonella (n = 13). Pyrosequencing generated more than 150,000 sequences, representing 113 distinct microbial taxa; the majority of observed community richness resulted from taxa present in low abundance with similar patterns of phyla distribution in clinically stable patients and patients at the onset of exacerbation. After treatment of exacerbation, there was no change in total (P = 0.925), aerobic (P = 0.917), or anaerobic (P = 0.683) load and only a limited shift in community composition. Agreement for detection of bacteria by culture and pyrosequencing was good for aerobic bacteria such as P. aeruginosa (κ = 0.84) but poorer for other genera including anaerobes. Lack of agreement was largely due to bacteria being detected by pyrosequencing but not by culture. CONCLUSIONS: A complex microbiota is present in the lungs of patients with bronchiectasis and remains stable through treatment of exacerbations, suggesting that changes in microbiota composition do not account for exacerbations.
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“With remarkable consistency, all studies report no increase in bacterial burden and no decrease in community diversity during exacerbations.”
From The microbiome and critical illness (2016) · cites this paper as [139]
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Global Initiative for Chronic Obstructive Lung Disease
Gerald, L. B., & Bailey, W. C. (2002) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200207000-00004 · Cited by 5,806
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
Hogg, J. C., Chu, F. S. F., Utokaparch, S., Woods, R. R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032158 · Cited by 3,828
Disordered Microbial Communities in Asthmatic Airways
Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,874
Fuchs, H. J., Borowitz, D., Christiansen, D. H., Morris, E. M., Nash, M. L., Ramsey, B. W., Rosenstein, B. J., Smith, A. L., & Wohl, M. E. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409083311003 · Cited by 1,532
Intermittent Administration of Inhaled Tobramycin in Patients with Cystic Fibrosis
Ramsey, B. W., PEPE, M. S., Quan, J. M., Otto, K., Montgomery, A. B., Williams‐Warren, J., Vasiljev-K, M., Borowitz, D., Bowman, C. M., Marshall, B. C., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400104 · Cited by 1,296
Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease
Sethi, S., & Murphy, T. F. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800353 · Cited by 1,238
Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract
Charlson, E. S., Bittinger, K., Haas, A. R., Fitzgerald, A. S., Frank, I., Yadav, A., Bushman, F. D., & Collman, R. G. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201104-0655oc · Cited by 1,144
British Thoracic Society guideline for non-CFbronchiectasis
Pasteur, M. C., Bilton, D., Hill, A. T., & on behalf of the British Thoracic Society Bronchiectasis (non-CF) Guideline Group (2010) · Thorax · doi:10.1136/thx.2010.136119 · Cited by 1,043
Analysis of the lung microbiome in the “healthy” smoker and in COPD.
Erb-Downward, J. R., Thompson, D. L., Han, M. K., Freeman, C. M., McCloskey, L., Schmidt, L. A., Young, V. B., Toews, G. B., Curtis, J. L., Sundaram, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016384 · Cited by 973 · cited 6×
“For example, genomic differences have been shown to be associated with the ability of H. influenzae strains to cause exacerbations of COPD (51).”
BackgroundResultInfluentialMechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications
Kanoh, S., & Rubin, B. K. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00078-09 · Cited by 722
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Research works printed but not linked: 1
- Einarsson, 2011, Microbial community composition in the lungs of patients with cystic fibrosis and non-CF bronchiectasis [abstract], Thorax, 66, A48
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Items 301–320 of 320
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Wang, W., Wang, Y., Xu, J. F., Song, Y.-L., & Xu, J. (2025) · BMC Pulmonary Medicine · doi:10.1186/s12890-025-03892-7
Swine influenza-modified pulmonary microbiota
Arranz-Herrero, J., Izpura-Luis, S., Presa, J., Reche-Sainz, P., Encinas, P., Kwon, T., Rius‐Rocabert, S., Tur-Planells, V., de Tejerina, J. C. D. F., Ochando, J., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1634469
Mohod, S. V., Sheikh, R., Choudhary, B., Vijay, M., & Agrawal, G. N. (2025) · Cureus · doi:10.7759/cureus.93015
The role of respiratory viruses in exacerbations of cystic fibrosis in adults
Flight, W. G. (2014) · Research Explorer (The University of Manchester)
Konecna, E., Videnska, P., Burešová, L., Urík, M., Smetanová, S., Smatana, S., Prokes, R., Lanickova, B., Budínská, E., Klánová, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812557
Konecna, E., Videnska, P., Burešová, L., Urík, M., Smetanová, S., Smatana, S., Prokes, R., Lanickova, B., Budínská, E., Klánová, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812566
Konecna, E., Videnska, P., Burešová, L., Urík, M., Smetanová, S., Smatana, S., Prokes, R., Lanickova, B., Budínská, E., Klánová, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812563
Additional file 2 of Bronchiectasis in renal transplant patients: a cross-sectional study
Mulette, P., Perotin, J.-M., Muggeo, A., Guillard, T., Brisebarre, A., Meyer, H., Hagenburg, J., Ancel, J., Dormoy, V., Vuiblet, V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26680298
Additional file 1 of Bronchiectasis in renal transplant patients: a cross-sectional study
Mulette, P., Perotin, J.-M., Muggeo, A., Guillard, T., Brisebarre, A., Meyer, H., Hagenburg, J., Ancel, J., Dormoy, V., Vuiblet, V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26680295
Liu, C., Wu, K., Sun, T., Chen, B., Yi, Y., Ren, R., Xie, L., & Xiao, K. (2022) · Figshare · doi:10.6084/m9.figshare.20545806
Konecna, E., Videnska, P., Burešová, L., Urík, M., Smetanová, S., Smatana, S., Prokes, R., Lanickova, B., Budínská, E., Klánová, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812548
Konecna, E., Videnska, P., Burešová, L., Urík, M., Smetanová, S., Smatana, S., Prokes, R., Lanickova, B., Budínská, E., Klánová, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812572
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Wiltingh, H. W., Marchant, J. M., Chang, A. B., & Goyal, V. (2026) · Children · doi:10.3390/children13020174
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Farhat, E. S., Halim, A. A. E., Elessawy, A. F., Elhefny, R., Ahmed, M. I., Ahmed, A. M., & Fouad, S. A. (2026) · BMC Pulmonary Medicine · doi:10.1186/s12890-026-04378-w
Wu, B., Lu, S., & Liu, H. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1907636
Pulmonary tuberculosis or nocardiosis? A clinical case discussion
Umpeleva, T. V., Kildyusheva, E., Ovchinnikova, E. A., Skornyakov, S. N., & Vakhrusheva, D. V. (2026) · Tuberkulez i socialʹno značimye zabolevaniâ · doi:10.54921/2413-0346-2026-14-1-60-65
Sputum microbiome and clinical profiles in Portuguese non-cystic fibrosis bronchiectasis patients
Araújo, R., Oliveira, L., Azevedo, I., & Amorim, A. A. (2026) · Pulmonology · doi:10.1080/25310429.2026.2730867
Liang, L., Liu, L., 黄, 草., Zeng, Z., & Zhu, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1987219
Metadata
- Authors
- Tunney, M. M., Einarsson, G. G., Wei, L., Drain, M., Klem, E. R., Cardwell, C., Ennis, M., Boucher, R. C., Wolfgang, M. C., & Elborn, J. S.
- Affiliations
- Cystic Fibrosis and Airways Microbiology Research Group
- Centre for Infection and Immunity, School of Medicine, Dentistry, and Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom
- University of North Carolina at Chapel Hill (US)
- Queen's University Belfast (GB)
- Corresponding author
- Tunney, Michael M.
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-05
- Volume
- 187
- Issue
- 10
- Pages
- 1118-1126
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC3734618
- OpenAlex
- W2116345416
- Cited by
- 316
- References
- 62
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 25 · 2023: 21 · 2022: 20 · 2021: 22 · 2020: 18 · 2019: 24 · 2018: 37 · 2017: 35 · 2016: 31 · 2015: 26 · 2014: 31 · 2013: 6
- FWCI
- 25.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- Public Health Agency (STL/3713/07, CDV/3650/07)
- National Heart, Lung, and Blood Institute (R01HL092964, HL092964)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bronchiectasis, lung microbiome, bacterial abundance, exacerbations, sputum microbiome, Pseudomonas aeruginosa, Haemophilus influenzae, Prevotella, Veillonella, anaerobic bacteria, bacterial community composition, antibiotic therapy
- MeSH terms
- Aged, Anti-Bacterial Agents, Bronchiectasis, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Lung, Male, Sputum, Cohort Studies, Metagenome
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