Intraalveolar catecholamines and the human lung microbiome
Open accessAbstract
biomarkers are encouraging and show that we have indeed targeted BMPR2 in patients with reduced levels of BMPR2.It will be of interest to determine whether the same effect can be achieved in patients with documented mutations and whether a subset of patients is particularly sensitive to the beneficial effects of this strategy and could therefore be identified up front as potential "responders" on the basis of BMPR2 levels.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In acute illness, the normally nutrient-poor alveolus is flooded with nutrient-rich oedema, oxygen and temperature gradients are established, and host stress signalling molecules selectively promote the growth of potential pathogens.
“The normally nutrient-poor environment of the alveolus is flooded with nutrient-rich oedema,55 pockets of oxygen and heterogeneous temperature gradients are established,48,49 and the signalling molecules of the host stress response selectively promote the growth of potential pathogens.”
From The microbiome and critical illness (2016) · cites this paper as [50]
These features of bacterial pneumonia correlate tightly with multiple indices of host inflammation, including alveolar neutrophilia and high alveolar concentrations of catecholamines and TNF-α.
“These features correlate tightly with multiple indices of host inflammation, including alveolar neutrophilia93 and high alveolar concentrations of catecholamines50 and TNF-α.”
From The microbiome and critical illness (2016) · cites this paper as [50]
In human bronchoalveolar lavage samples, increased alveolar catecholamine concentrations correlate strongly with collapse of the lung microbiome around one dominant species, most frequently P aeruginosa.
“In human bronchoalveolar lavage samples, increased alveolar catecholamine concentrations correlate strongly with collapse of the lung microbiome around one dominant species (most frequently P aeruginosa”
From The microbiome and critical illness (2016) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The role of the microbiome in exacerbations of chronic lung diseases
Dickson, R. P., Martinez, F. J., & Huffnagle, G. B. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61136-3 · Cited by 495 · see citing works
Self-citationPhagocyte-derived catecholamines enhance acute inflammatory injury
Flierl, M. A., Rittirsch, D., Nadeau, B. A., Chen, A. J., Sarma, J. V., Zetoune, F. S., McGuire, S. R., List, R. P., Day, D. E., Hoesel, L. M., et al. (2007) · Nature · doi:10.1038/nature06185 · Cited by 475 · see citing works
Catecholamine induced growth of gram negative bacteria
Lyte, M., & Ernst, S. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90273-r · Cited by 396 · see citing works
Dickson, R. P., Erb-Downward, J. R., & Huffnagle, G. B. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70028-1 · Cited by 371 · see citing works
Scales, B. S., Dickson, R. P., LiPuma, J. J., & Huffnagle, G. B. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00044-14 · Cited by 303 · see citing works
Self-citationLung Infection—A Public Health Priority
Mizgerd, J. P. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030076 · Cited by 293 · see citing works
Marks, L. R., Davidson, B. A., Knight, P. R., & Hakansson, A. P. (2013) · mBio · doi:10.1128/mbio.00438-13 · Cited by 240 · see citing works
Dickson, R. P., Erb‐Downward, J. R., Freeman, C. M., Walker, N., Scales, B. S., Beck, J. M., Martínez, F. J., Curtis, J. L., Lama, V. N., & Huffnagle, G. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097214 · Cited by 203 · see citing works
Self-citationDickson, R. P., Erb-Downward, J. R., Prescott, H. C., Martinez, F. J., Curtis, J. L., Lama, V. N., & Huffnagle, G. B. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01028-14 · Cited by 176 · see citing works
Self-citationPseudomonas aeruginosa -Catecholamine Inotrope Interactions
Freestone, P. P., Hirst, R. A., Sandrini, S. M., Sharaff, F., Fry, H., Hyman, S., & O'Callaghan, C. (2012) · Chest · doi:10.1378/chest.11-2614 · Cited by 107 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Microbiome and the Respiratory Tract
Dickson, R. P., Erb-Downward, J. R., Martinez, F. J., & Huffnagle, G. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105238 · Cited by 953 · see citing works
Self-citationThe microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works
Self-citation
- Authors
- Dickson, R. P., Erb-Downward, J. R., Prescott, H. C., Martinez, F. J., Curtis, J. L., Lama, V. N., & Huffnagle, G. B.
- Affiliations
- University of Michigan (US)
- University of Michigan Medical School, Ann Arbor, Michigan
- Weill Cornell Medical College, New York, New York
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-07
- Volume
- 192
- Issue
- 2
- Pages
- 257-259
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC4532827
- OpenAlex
- W1780474465
- Cited by
- 59
- References
- 10
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 13 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 4
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (T32HL00774921, U01HL098961, R01HL094622, R01HL118017, R01HL114447)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- lung microbiome, BMPR2, pulmonary arterial hypertension, biomarkers, BMPR2 mutations, targeted therapy
- MeSH terms
- Bronchoalveolar Lavage Fluid, Catecholamines, Humans, Lung, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
