Catecholamine induced growth of gram negative bacteria
Abstract
The addition of various catecholamines to cultures of gram negative bacteria resulted in dramatic increases in growth. The ability of norepinephrine, epinephrine, dopamine and dopa to enhance the growth of Escherichia coli, Yersinia enterocolitica and Pseudomonas aeruginosa was observed to be dependent on the bacterium employed with each strain showing marked preference for one or more of the catecholamines. Catecholamine induced increases in growth were confirmed by one or more of the following methods: uptake of tritiated thymidine into newly synthesized DNA, changes in optical density or pour plate analysis. None of the catecholamine metabolites resulting from either oxidative deamination or catechol-O-methylation were able to effect similar increases in bacterial growth as compared to either norepinephrine, epinephrine or dopamine. Norepinephrine was consistently observed to effect the greatest increase in bacterial growth for all strains tested.
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Bacteria produce noradrenaline as a quorum sensing molecule, and noradrenaline and adrenaline can promote pathogenesis and growth.
“bacteria produce noradrenaline as a quorum sensing molecule, and noradrenaline and adrenaline can promote pathogenesis and growth (229, 230)”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [230]
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- Authors
- Lyte, M., & Ernst, S.
- Affiliations
- Minnesota State University, Mankato (US)
- Corresponding author
- Lyte, Mark
- ORCID
- Lyte, Mark
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 50
- Issue
- 3
- Pages
- 203-212
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2085147597
- Cited by
- 396
- References
- 9
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 19 · 2023: 20 · 2022: 20 · 2021: 31 · 2020: 24 · 2019: 23 · 2018: 23 · 2017: 11 · 2016: 25 · 2015: 11 · 2014: 20 · 2013: 13 · 2012: 13
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh045246-05)
- Directorate for Biological Sciences
- National Institute of Mental Health (MH45246)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- catecholamines, bacterial growth stimulation, Gram-negative bacteria, norepinephrine, epinephrine, dopamine, DOPA, Escherichia coli, Yersinia enterocolitica, Pseudomonas aeruginosa, catecholamine metabolites, oxidative deamination, DNA synthesis
- MeSH terms
- Catecholamines, Escherichia coli, Gram-Negative Bacteria, Microbiological Techniques, Phenotype, Pseudomonas aeruginosa, Yersinia enterocolitica, Colony Count, Microbial
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